HAMMOCK LAB
The Laboratory of Pesticide Biotechnology
1399. Yang H, Qi M, He Q, Hwang SH, Yang J, McCoy M, Morisseau C, Zhao S, Hammock BD. Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA. J Pharm Anal. 2023 Sep;13(9):1013-1023. doi: 10.1016/j.jpha.2023.05.006 [Download]
1400. Peyman M, Barroso E, Turcu AL, Estrany F Jr, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde ÁM, Palomer X, Galdeano C, Vázquez S, Vázquez-Carrera M. Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. Biomed Pharmacother. 2023 Dec;168:115667. doi: 10.1016/j.biopha.2023.115667 [Download]
1401. Ravindran R, Kang H, McReynolds C, Sanghar GK, Chang WLW, Ramasamy S, Kolloli A, Kumar R, Subbian S, Hammock BD, Hartigan-O'Connor DJ, Ikram A, Haczku A, Khan IH. Dynamics of temporal immune responses in nonhuman primates and humans immunized with COVID-19 vaccines. PLoS One. 2023;18(10):e0287377. doi: 10.1371/journal.pone.0287377 [Download]
1403. Warner JB, Hardesty JE, Song YL, Floyd AT, Deng Z, Jebet A, He L, Zhang X, McClain CJ, Hammock BD, Warner DR, Kirpich IA. Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease. Am J Pathol. 2024 Jan;194(1):71-84. doi: 10.1016/j.ajpath.2023.09.016 [Download]
1409. Kulkarni R, Mehta R, Goswami SK, Hammock BD, Morisseau C, Hwang SH, Mallappa O, Azeemuddin MM, Rafiq M, S N M. Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice. Biochem Biophys Res Commun. 2023 Jul 30;667:64-72. doi: 10.1016/j.bbrc.2023.05.008 [Download]
1410. Kim D, Horimatsu T, Ogbi M, Goo B, Shi H, Veerapaneni P, Chouhaita R, Moses M, Prasad R, Benson TW, Harb R, Aboud G, Seller H, Haigh S, Fulton DJ, Csányi G, Huo Y, Long X, Coffey P, Lee R, Guha A, Zeldin D, Hwang SH, Hammock BD, Weintraub NL, Kim HW. Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis. bioRxiv. 2023 Jul 11:2023.07.10.548127. doi: 10.1101/2023.07.10.548127 [Download]
1411. Hrithrik TH, Lee DH, Singh N, Vik A, Hammock BD, Kim Y. Insect immune resolution with EpOME/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity. bioRxiv. 2023 Jul 7:2023.07.07.548078. doi: 10.1101/2023.07.07.548078 [Download]
1413. Wang Y, Morisseau C, Takamura A, Wan D, Li D, Sidoli S, Yang J, Wolan DW, Hammock BD, Kitamura S. PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction. ACS Chem Biol. 2023 Apr 21;18(4):884-896. doi: 10.1021/acschembio.3c00017 [Download]
1416. Trindade-da-Silva CA, Yang J, Fonseca F, Pham H, Napimoga MH, Abdalla HB, Aver G, De Oliveira MJA, Hammock BD, Clemente-Napimoga JT. Eicosanoid profiles in an arthritis model: Effects of a soluble epoxide hydrolase inhibitor. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Mar;1869(2):159432. doi: 10.1016/j.bbalip.2023.159432 [Download]
1417. Pu Y, Cheng R, Zhang Q, Huang T, Lu C, Tang Z, Zhong Y, Wu L, Hammock BD, Hashimoto K, Luo Y, Liu Y. Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Clin Immunol. 2023 Dec;257:109850. doi: 10.1016/j.clim.2023.109850 [Download]
1418. Oh YT, Yang J, Stefanovski D, Hammock B, Youn JH. Determinants of Meal-Induced Changes in Circulating FFA Epoxides, Diols, and Diol-to-Epoxide Ratios as Indices of Soluble Epoxide Hydrolase Activity. Int J Mol Sci. 2023 Dec 11;24(24). doi: 10.3390/ijms242417351 [Download]
1420. Wang W, Wang Y, Yang J, Wagner KM, Hwang SH, Cheng J, Singh N, Edwards P, Morisseau C, Zhang G, Panigrahy D, Hammock BD. Aflatoxin B(1) exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner. Ecotoxicol Environ Saf. 2023 Jan 1;249:114417. doi: 10.1016/j.ecoenv.2022.114417 [Download]
1421. Naeem Z, Zukunft S, Huard A, Hu J, Hammock BD, Weigert A, Frömel T, Fleming I. Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli. Biomed Pharmacother. 2024 Jan 9;171:116127. doi: 10.1016/j.biopha.2024.116127 [Download]
1422. Abdalla HB, Puhl L, Rivas CA, Wu YC, Rojas P, Trindade-da-Silva CA, Hammock BD, Maddipati KR, Soares MQS, Clemente-Napimoga JT, Kantarci A, Napimoga MH, Van Dyke TE. Modulating the sEH/EETs Axis Restrains Specialized Proresolving Mediator Impairment and Regulates T Cell Imbalance in Experimental Periodontitis. J Immunol. 2024 Feb 1;212(3):433-445. doi: 10.4049/jimmunol.2300650. [Download]
1424. Duan JX, Guan XX, Cheng W, Deng DD, Chen P, Liu C, Zhou Y, Hammock BD, Yang HH. COX-2/sEH-Mediated Macrophage Activation Is a Target for Pulmonary Protection in Mouse Models of Chronic Obstructive Pulmonary Disease. Lab Invest. 2023 Dec 27;104(3):100319. doi: 10.1016/j.labinv.2023.100319. [Download]
1428. Kelly AG, Wang W, Rothenberger E, Yang J, Gilligan MM, Kipper FC, Attaya A, Gartung A, Hwang SH, Gillespie MJ, Bayer RL, Quinlivan KM, Torres KL, Huang S, Mitsiades N, Yang H, Hammock BD, Panigrahy D. Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2314085121. doi: 10.1073/pnas.2314085121 [Download]
1431. Chen Y, Sun J, Tong H, Wang J, Cao R, Xu H, Chen L, Morisseau C, Zhang M, Shi Y, Han C, Zhuang J, Jing Y, Liu Z, Hammock BD, Chen G. Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality. J Med Chem. 2024 Feb 8;67(3):2095-2117. doi: 10.1021/acs.jmedchem.3c02006. [Download]
1432. Burmistrov VV, Morisseau C, Danilov DV, Gladkikh BP, D'yachenko VS, Zefirov NA, Zefirova ON, Butov GM, Hammock BD. Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2274797. doi: 10.1080/14756366.2023.2274797. [Download]
1433. Steffan BN, Calise D, Park SC, Niu M, Yang J, Hammock BD, Jones M, Steele C, Keller NP. Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis. Front Immunol. 2023;14:1173544. doi: 10.3389/fimmu.2023.1173544. [Download]