Principal Investigator - Dr. Bruce Hammock
Distinguished Professor of Entomology & Nematology at UCD
Comprehensive Cancer Center
Director, NIEHS-UCD Superfund Research Program
90 Briggs Hall
Tel: (530) 752-7519
Fax: (530) 752-1537
B.S. Entomology/Zoology & Chemistry, Louisiana State University, LA
Ph.D. Entomology/Toxicology, University of California, Berkeley, CA
Develop the technologies for application of immunochemistry to toxicological & environmental research. Develop mono- and polyclonal based immunoassays for environmental contaminants. Develop immunoassay systems to evaluate human exposure. Explore monoclonal, polyclonal and cloned antibodies for biosensor development.
2. Insect Research
Exploit a fundamental understanding of insect developmental biology for the control of insect pests. Develop site-directed inhibitors for enzymes involved in juvenile hormone metabolism. Design chemical and biochemical agents for the disruption of insect development. Use cloned proteins expressed in baculovirus vectors for insect control. Investigate regulation of endocrine events at the molecular level.
3. Mammalian Research
Examine effect of hepatic enzymes on foreign compounds in diet & the influence of these compounds on hepatic enzymes. Examine the mechanism of action of nongenotoxic carcinogens & their influence on esterases, epoxide hydrolases, & glutathione transferases. Design selective inhibitors, substrates & purification systems for hepatic esterases & epoxide hydrolases. Clone and hyper-express esterases and epoxide hydrolases for structural and toxicological studies.