HAMMOCK LAB
The Laboratory of Pesticide Biotechnology
856. Qiu, H., J.Y. Liu, D.G. Wei, N. Li, E.N. Yamoah, B.D. Hammock and N. Chiamvimonvat. 2012. Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. Cardiovasc Res. 95(3):336-45. PMCID: PMC3400359. [Download]
857. Sanders W., B.D. Hammock, A. K. Cheung and C. Terry. 2012. Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor. Am J Physiol Cell Physiol. 303(3):C278-90. PMCID: PMC3423028. [Download]
858. Lin Y.P., J. Ubels, M. Schotanus, B.D. Hammock and M. Watsky. 2012. Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation. Curr Eye Res. 37(10):871-78. PMCID: PMC3572765. [Download]
859. Cherednichenko, G., R. Zhang, R.A. Bannister, V. Timofeyev, N. Li, E.B. Fritsch, W. Feng, G.C. Barrientos, N.H. Schebb, B.D. Hammock, K.G. Beam, N. Chiamvimonvat and I.N. Pessah. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U.S.A. 109(35):14158-63. PMCID: PMC3435154. [Download]
860. Zhang, W., A.L. Liao, H. Li, H. Dong, Y.T. Chung, H. Bai, K.A. Matkowskyj, A. Yang, B.D. Hammock and G.Y. Yang. 2012. Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice. Dig Dis Sci. 57(10):2580-91. PMCID: PMC3664520. [Download]
861. Yueh, M.F., T. Li, R.M. Evans, B.D. Hammock and R.H. Tukey. 2012. Triclocarbon mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One. 7(6):e37705. PMCID: PMC3376094. [Download]
862. Decker, M., M. Adamska, A. Cronin, F. DiGiallonardo, J. Burgener, A. Marowshy, J.R. Falck, C. Morisseau, B.D. Hammock, A. Gruzdev, D.C. Zeldin and M. Arand. 2012. EH3 (ABHD9) - the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. J Lipid Res. 53(10):2038-45. PMCID: PMC3435537. [Download]
863. Kopkan, L., Z. Husková, A. Sporková, Š. Varcabová, Z. Honetschlägerová, S.H. Hwang, H.J. Tsai, B.D. Hammock, J.D. Imig, H.J. Kramer and L. Cervenka. 2012. Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension. 35(6):595-607. Kidney Blood Press Res. PMCID:PMC3604982. [Download]
864. Kim, I.H., K. Nishi, T. Kasagami, C. Morisseau, J.Y. Liu, H.J. Tsai and B.D. Hammock. 2012. Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorg Med Chem Lett. 22(18):5889-92. PMCID: PMC3432147. [Download]
865. Guglielmino, K., K. Jackson, T. Harris, V. Vu, H. Dong, G. Dutrow, J. Evans, J. Graham, B. Cummings, P. Havel, N. Chiamvimonvat, S. Despa, B.D. Hammock and F. Despa. 2012. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 303(7):H853-62. PMCID: PMC3469704. [Download]
867. Zivkovic, A.M., J. Yang, K. Georgi, C. Hegedus, M.L. Nording, A. O’Sullivan, J.B. German, R.J. Hogg, R.H. Weiss, C. Bay and B.D. Hammock. 2012. Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations. Metabolomics. 8(6):1102-13. PMCID: PMC3700377. [Download]
869. Tamang, D.L., W. Pirzai, G.P. Priebe, G.B. Pier, J.R. Falck, C. Morisseau,B.D. Hammock, B.A. McCormick, K. Cronert and B. P. Harley. 2012. Hepoxilin A3 Facilitates Neutrophilic Breach of Lipoxygenase-expressing Airway Epithelial Barriers. J Immunol. 189(10):4960-69. PMCID: PMC3490410 [Download]
871. Cao, Z.Y., B.D. Hammock, M. McCoy, R.A. Michael, P.J. Lein and I.M. Pessah. 2012. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA blockade and GABAA receptor positive modulation. Toxicological Sciences. 130(2):362-72. PMCID: PMC3529644. [Download]
874. Pecic S., S. Pakhomova, M.E.Newcomer, C. Morisseau, B.D. Hammock, Z. Zhu, A. Rinderspacher and S.X. Deng. 2013. Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 23(2): 417-21. PMCID: PMC3541548. [Download]
875. Falck, D., N.H. Schebb, S. Prihatiningtyas, J.W. Zhang, F. Heus, C. Morisseau, J. Kool, B.D. Hammock and W.M.A. Niessen. 2013. Development of on-line liquid chromatography-biochemical detection for soluble epoxide hydrolase inhibitors in mixtures. Chromatographia. 76(1-2):13-21. PMCID: PMC3601784. [Download]
876. Morisseau, C., S. Sahdeo, G. Cortopassi and B.D. Hammock. 2012. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem. 434(1): 105-11. PMCID: PMC3557602. [Download]
877. Morisseau, C. and B.D. Hammock. 2013. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol. 53:37-58. PMCID: PMC3578707. [Download]
878. Honetschlägerová, Z., K. Kitada, Z. Husková, A. Sporková, L. Kopkan, M. Bürgelová, Š. Varcabová, A. Nishiyama, S.H. Hwang, B.D. Hammock, J.D. Imig, H.J. Kramer, P. Kujal, Z. Vernerová and L. Cervenka. 2013. Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ang II-dependent malignant hypertension are abolished by pretreatment with L-name. J Hypertens. 31(2):321-332. PMCID: PMC3769696. [Download]
879. Kundu, S., T. Roome, K.A. Carnevale, V.P. Yakubenko, A. Bhattacharjee, S.H. Hwang, B.D. Hammock and M.K. Cathcart. 2013. Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo. J Lipid Res. 54(2):436-47. PMCID: PMC3588870. [Download]
880. Wang, Q., W. Pang, Z. Cui, J.B. Shi, Y. Liu, B. Liu, Y.F. Zhou, Y.F. Guan, B.D. Hammock, Y. Wang and Y. Zhu. 2013. Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage. Am J Physiol Renal Physiol. 304(2):F168-76. PMCID: PMC3543623. [Download]
882. Wettersten, H.I., S.H. Hwang, C. Li, E.Y. Shiu, A.T. Wecksler, B.D. Hammock and R.H. Weiss. 2013. A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol Ther. 14(3):278-285. PMCID: PMC3595311. [Download]
883. Kamita, S.G., K. Yamamoto, M.M. Dadala, K. Pha, C. Morisseau, A. Escaich and B.D. Hammock. 2013. Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem Mol Biol. 43(2013)219-228. PMCID: PMC357795. [Download]
884. Imig, J.D., K. Walsh, M.A.H. Khan, T. Mahasawa, M. Cherian-Shaw, S.M. Shaw and B.D Hammock. 2012. Soluble epoxide hydrolase inhibition and PPARγ; agonist improve vascular function and decrease renal injury in hypertensive obese rat. Exp Biol Med (Maywood). 237(12):1402-12. PMCID:PMC3613242. [Download]
885. Wagner, K., B. Inceoglu, H. Dong, J. Yang, S.H. Hwang, P. Jones, C. Morisseau and B.D. Hammock. 2013. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur J Pharmacol. 700(1-3):93-101. PMCID: PMC3578047. [Download]
886. Lee, K.S.S., C. Morisseau, J. Yang, P. Wang, S.H. Hwang and B.D. Hammock. 2013. Förster resonance energy transfer (FRET) competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem. 434(2):259-268. PMCID: PMC3632402. [Download]
887. Liu, J.Y.,Y.P. Lin, H. Qiu, C. Morisseau, T.E.Rose, S.H. Hwang, N. Chiamvimonvat and B.D. Hammock. 2013. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 48(4-5): 619-627. PMCID: PMC3596469. [Download]
888. Stewart, D.N., J.Lango, K.P. Nambiar, M.J. S. Falso, P.G. FitzGerald, D.M. Rocke, B.D. Hammock and B.A. Buchholz. 2013. Carbon turnover in water-soluble protein of the adult human lens. Mol Vis.19:463-475. PMCID: PMC3580966. [Download]
892. Hwang, S.H., A.T. Wecksler, K. Wagner and B.D. Hammock . 2013. Rationally designed multitarget agents against inflammation and pain. Curr Med Chem. 20(13): 1783-99. [Download]
893. Sirish, P., N. Li, J.Y. Liu, K.S. S. Lee, S.H. Hwang, H. Qiu, S.M. Ma, J.E. López1, B.D. Hammock and N. Chiamvimonvat. 2013. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U.S.A. 110(14):5618-23. PMCID: PMC3619365. [Download]
894. Varcabová Š., Z. Husková, H.J. Kramer, S.H. Hwang, B.D. Hammock, J.D. Imig and L. Cervenka. 2013. Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system. Clin Exp Pharmacol Physiol. 40(4):273-81. PMCID: PMC3769696. [Download]
895. Althurwi, H.N., M.M. Tse, G. Abdelhamid, B.N. Zordoky, B.D. Hammock and A.O. El-Kadi. 2013. Soluble epoxide hydrolase inhibitor, TUPS, protects against isoproterenol-induced cardiac hypertrophy. Br J Pharmacol. 168(8):1794-807. PMCID: PMC3623051. [Download]
896. Zhang, G.D., D. Panigraphy, L. Mahakian, J. Yang, J.Y. Liu, K.S.S. Lee, H.I. Wettersten, A. Ulu, X. Hu, S. Tam, S.H. Hwang, E. Ingham, R.H. Weiss, K.W. Ferrara and B.D. Hammock. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth and metastasis. Proc Natl Acad Sci USA. 110(16):6530-35. PMCID: PMC3631682. [Download]
897. Bettaieb, A., N. Nagata, D. AbouBechara, S. Chahed, C. Morisseau, B.D. Hammock and F.G. Haj. 2013. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem. 288(20): 14189-99. PMCID: PMC3656275. [Download]
898. de Medina, P., M.R. Paillasse, G. Segala, M. Voisin, L. Mhamdi, F. Dalenc, M. Lacroix-Triki, T. Filleron, F. Pont, T. Al Saati, C. Morisseau, B.D. Hammock, S. Silvente-Poirot and M. Poirot. 2013. Dendrogenin A arises from cholesterol and histamine metabolism and show cell differentiation and anti-tumour properties. Nat Commun. 4:1840. PMCID: PMC3674249 [Download]
899. Poli, G., E. Corda, P.A. Martino, P.D. Ara, S. R. Bareggi, G. Bondiolotti, B. Iulini, M. Mazza, C. Casalone, S.H. Hwang, B.D. Hammock and B. Inceoglu. 2013. Therapeutic activity of inhibition of the soluble epoxide hydrolase, in a mouse model of scrapie. Life Sci. 92(23):1145-50. PMICD: PMC3806320. [Download]
900. Boestena, D.M.P.H.J., A. Bergerb, P. de Cock, H. Dong, B.D. Hammock, G.M. den Hartoga and A. Basta. 2013. Multi-targeted mechanisms underlying the endothelial protective effects of the diabetic-safe sweetener erythritol. PLoS One. 8(6):e65741. PMCID: PMC3673924 [Download]
901. Guedes, A., C. Morisseau, A. Sole, J.H. Soares, A. Ulu, H. Dong and B.D. Hammock. 2013. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg. 40(4):440-48. PMCID: PMC3956586. [Download]
902. Schuchardt, J.P., S. Schmidt, G. Kressel, H. Dong, I. Willenberg, B.D. Hammock, A. Hahn and N.H. Schebb. 2013. Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. Prostaglandins Leukot Essent Fatty Acids. 89(1):19-29. [Download]
903. Hwang, S.H., A.T. Wecksler, G.D. Zhang, C. Morisseau, L. Nguyen, S. Fu and B.D. Hammock. 2013. Synthesis and Biological Evaluation of Sorafenib- and Regorafenib-like sEH Inhibitors. Bioorg Med Chem Lett. 23(13):3732-37. PMCID: PMC3744640. [Download]
904. Morisseau, C., S. Pakhomova, S.H. Hwang, M.E. Newcomer and B.D. Hammock. 2013. Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg Med Chem Lett. 23(13): 3818-21. PMCID: PMC3703951. [Download]
905. Kamita, S.G., G.H. Oshita, P. Wang, R.S. Nandety, C. Morisseau, B.W. Falk and B.D. Hammock. 2013. Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis. Arch Insect Biochem Physiol. 83(4):171-79. PMCID: PMC3846607. [Download]
906. Chen, L.D., C. Fan, Y. Zhang, M. Bakri, K. Maddipati, C. Morisseau, C.Y. Wang, B.D. Hammock and M.H. Wang. 2013. Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins Other Lipid Mediat. 104-105:42-48. [Download]
908. Xu, D.Y., B.B. Davis, Z.H. Wang, S.P. Zhao, B. Wasti, Z.L. Liu, N. Li, C. Morisseau, N. Chiamvimonvat and B.D. Hammock. 2013 Aug. A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARγto modulate the function of endothelial progenitor cells from patients with acute myocardial infarction. Int J Cardiol. 167(4):1298-1304. PMCID: PMC3821736. [Download]
909. Lundström, S.L., J. Yang, J. Brannan, J.Z. Haeggström, B.D. Hammock, P. Nair, P. O’Byrne, S.E. Dahlén, C.E. Wheelock. 2013 Aug. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Mol Nutr Food Res. 57(8):1378-89. [Download]
910. Smilowitz, J.T., A.M. Zivkovic, Y.Wan, S.M. Watkins, M.L. Nording, B.D. Hammock and J.B. German. 2013 Aug. Nutritional lipidomics: Molecular metabolism, analytics, and diagnostics. Mol Nutr Food Res. 57(8):1319-35. PMCID: PMC3943463. [Download]
911. Harris, T.R. and B.D. Hammock. 2013 Sept. Soluble epoxide hydrolase: gene structure, expression and deletion. Gene. 526(2):61-74. PMCID: PMC3733540. [Download]
912. Frolov, A., H. Dong, M. Jiang, L.H Yang, E.C. Cook, R. Matnani, B.D. Hammock and L. J. Crofford. 2013 Aug. Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. J Biol Chem. 288(33):23696-703. PMCID: PMC3745317. [Download]
913. Panigrahy D., B.T. Kalish, S. Huang, D.R. Bielenberg, H.D. Le, J. Yang, M.L. Edin, C.R. Lee, O. Benny, D.R. Mudge, C.E. Butterfield, A. Mammoto, T. Mammoto, B. Inceoglu, R.L. Jenkins, M. Simpson, T. Akino, F.B. Lih, K.B. Tomer, D.E. Ingber, B.D. Hammock, J.R. Falck, V.L. Manthati, A. Kaipainen, P.A. D’Amore, M. Puder, D.C. Zeldin and M.W. Kieran. 2013 Aug. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci USA. 110(33):13528-33. PMCID: PMC3746918. [Download]
914. Lee, A.R., A. Pechenino, H. Dong, B.D. Hammock, A.A.Knowlton. 2013 Aug. Aging, Estrogen Loss and Epoxyeicosatrienoic Acids (EETs). PLoS One. 8(8):e70719. PMCID: PMC3742755. [Download]
915. Zhang, W.Y., J. Liao, H.N. Li, H. Dong, H. Bai, A. Yang, B.D. Hammock and G.Y. Yang. 2013 Sept. Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency. Mol Carcinog. 52(9): 726-38. PMCID: PMC3407328. [Download]
916. Ulu, A., T.R. Harris, C. Morisseau, C. Miyabe, H. Inoue, G. Schuster, H. Dong, J.Y. Liu, R. H. Weiss, N. Chiamvimonvat, J.D. Imig and B.D. Hammock. 2013 Sept. Anti-inflammatory effects of omega-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II dependent hypertension. J Cardiovasc Pharmacol. 62(3): 285-97. PMCID: PMC3773051. [Download]
918. Van Bogaert, I., G.D. Zhang, J. Yang, J.Y. Liu, Y.H. Ye, W. Soetaerta and B.D. Hammock. 2013 Sept. Preparation of 20-HETE using multifunctional enzyme type 2 (MFE-2)-negative Starmerella bombicola. J Lipid Res. 54(11):3215-19. PMCID: PMC3793626. [Download]
921. Nording, M.L., J. Yang, K. Georgi, C.H. Karbowski, J.B. German, R.H. Weiss, R.J. Hogg, J. Trygg, B.D. Hammock, A.M. Zivkovic. 2013 Oct. Individual variation in lipidomic profiles of healthy subjects in response to Omega-3 Fatty Acids. PLoS One. 8(10):e76575. [Download]
922. Park, E.K., S.K. Mak, B.D. Hammock. 2013. Effects of cadmium chloride on mouse inner medullary collecting duct cells. Interdiscip Toxicol.6(3):157-158. PMCID: PMC3811983. [Download]
923. Frolov, A., L. Yang, H. Dong, B.D. Hammock and L.J. Crofford. 2013 Oct. Anti-inflammatory properties of prostaglandin E2: Deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice. Prostaglandins Leukot Essent Fatty Acids. 89(5):351-58. PMCID: PMC3897272. [Download]
924. Yang, J., P. Solaimani, H. Dong, B.D. Hammock, O. Hankinson. 2013. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. J Toxicol Sci. 38(6):833-36. PMCID in process. [Download]
925. Shaik, J.S.B., M. Ahmad, W.J. Lee, M.E. Rose, L. Foley, K. Hitchens, S.H. Graham, S.H. Hwang, B.D. Hammock and S.M. Poloyac. 2013 Dec. Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke. Am J Physiol Heart Circ Physiol. 305(11):H1605-13. PMCID:PMC3882464. [Download]
926. Gardell, A.M., J. Yang, R. Sacchi, N.A. Fangue, B.D. Hammock and D. Kultz. 2013 Dec. Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. J Exp Biol. 26(24):4615-25. PMCID: PMC3851147. [Download]
928. Inceoglu, A.B., D. Zolkowska, H.J. Yoo, K.M. Wagner, J. Yang, E. Hackett, S.H. Hwang, K.S.S. Lee, M.A. Rogawski, C. Morisseau and B.D. Hammock. 2013 Dec. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. PLoS One. 8(12):e80922. PMCID: PMC3862847. [Download]
929. Chen, T., K. Takrouri, S.H. Hwang, S. Rana, J. Halperin, A. Natarajan, C. Morisseau, B.D. Hammock, M. Chorev and B.H. Aktas. 2013 Nov. Explorations of substituted urea functionality for discovery of new activators of the heme regulated inhibitor kinase. J Med Chem. 56(23):9457-70. PMCID: PMC3938169. [Download]
930. Zhang, G.D., S. Kodani and B.D. Hammock. 2013 Dec. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog Lipid Res. 53C: 108-123. PMCID: PMC3914417. [Download]
931. Kim, I.H., I.H. Lee, B.D. Hammock and K. Nishi. 2014 Feb. Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase. Bioorg Med Chem. 22(3): 1163-75. PMCID: PMC4172381. [Download]
932. Schuchardt, J.P., S. Schmidt, G. Kressel, I. Willenberg, B.D. Hammock, A. Hahn, N.H. Schebb. 2014 Feb. Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men. Prostaglandins Leukot Essent Fatty Acids. 90(2-3): 27-37. PMCID: PMC4130704. [Download]
933. Zhang, W., H. Li., H. Dong, J. Liao, S. Norwood, B.D. Hammock and G.Y. Yang. 2013 Dec. Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Res. 33(12):5261-71. PMCID: PMC604962. [Download]
934. Wecksler, A.T., S.H. Hwang, H.I. Wettersten, J.E. Gilda, A. Patton, L.J. Leon, K.L. Carraway III, A.V. Gomes, K. Baar, R. H. Weiss and B.D. Hammock. 2014 Apr. Novel sorafenib-based structural analogues: invitro anticancer evaluation oft-MTUCB and t-AUCMB. Anticancer Drugs.25(4):433-46. PMCID: PMC3947856. [Download]
935. Kalai, T., R. Altman, I. Maezawa, M. Balog, C. Morisseau, J. Petrlova, B.D. Hammock, L.W. Jin, J. Trudell, J.C. Voss and K. Hideg. 2014. Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors. Eur J Med Chem. 77:343-350. PMCID: PMC4065883. [Download]
936. Kujal, P., V. C. Chábová, P. Škaroupková, Z. Husková, Z. Vernerová, H.J. Kramer, A. Walkowska, E. Kompanowska-Jezierska, J. Sadowski, K. Kitada, S.H. Hwang, B.D. Hammock, J.D. Imig and L. Cervenka. 2014 Mar. Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clin Exp Pharmacol Physiol. 41(3):227-37. PMCID: PMC4038339. [Download]
937. Li, L., N. Li, W. Pang, X. Zhang, B.D. Hammock, D. Ai and Y. Zhu . 2014 Apr. Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis. PLoS One. 9(4):e94092. PMCID: PMC3981766. [Download]
938. Burmistrov, V., C. Morisseau, K.S.S. Lee, D.S. Shihadih, T.R. Harris, G.M. Butov and B.D. Hammock. 2014 May. Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 24(2014):2193-97. PMCID: PMC4019751. [Download]
940. Sun, D., A.J. Cuevas, K. Goltlinger, S.H. Hwang, B.D. Hammock, M. L. Schwartzman and A. Huang. 2014 Apr. Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure. Am J Physiol Heart Circ Physiol. 306:H1146-53. PMCID: PMC3989753. [Download]
941. Schuchardt, J.A., I. Schneider, I. Willenberg, J. Yang, B.D. Hammock, A. Hahn, N.H. Schebb. 2014. Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFAs. Prostaglandins Other Lipid Mediat. 109-111:23-31. PMCID: PMC4172375. [Download]
942. Schebb, N.H., J. Bharathi, D. Morin, R.H. Rice, B.D. Hammock and A.R. Buckpitt. 2014. Metabolic activation of the antibacterial agent, triclocarban, by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos. 42(7)1098:102. PMCID: PMC4170114. [Download]
943. Morisseau, C., A.T. Wecksler, C. Deng, H. Dong, J. Yang, K.S.S. Lee, S.D. Kodani and B.D. Hammock. 2014. Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity, and dimer formation. J Lipid Res.55:1131-38. PMCID: PMC4031944. [Download]
944. Charles, R.L., O. Rudyk, O. Prysyazhna, A. Kamynina, J. Yang, C. Morisseau, B.D. Hammock, B. Freeman and P. Eaton. 2014 Jun. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 111(22):8167-72. PMCID: PMC4050620. [Download]
945. Zhao, C., S.H. Hwang, B.A. Buchholz, F.C. Lightstone, T.S. Carpenter, J. Yang, B.D. Hammock and J.E. Casida. 2014. The GABAA Receptor Target of Tetramethylenedisulfotetramine. Proc Natl Acad Sci U S A. 111(23):8607-12. PMID: 24912155. [Download]
947. Sarnpitak, P., P. Mujumdar, C. Morisseau, S.H. Hwang, B.D. Hammock, V. Iurchenko, S. Zozulya, A. Gavalas, A. Geronikaki, T. Ivanenkov and M. Krasavin. 2014. Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core. Eur J Med Chem. 84C:160-72. [Download]
948. Ulu, A., K.S.S. Lee, C. Miyabe, J. Yang, B.G. Hammock, H. Dong and B.D. Hammock. 2014 Jul. An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II dependent hypertension. J Cardiovasc Pharmacol. 64(1):87-99. PMCID: PMC4092041. [Download]
949. Huang, S.X., B. Cao, C. Morisseau, Y. Jin, B.D. Hammock and Y.Q. Long. 2012. Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase. Medchemcomm. 3:379-84. [Download]
950. Zhang, G., D. Panigrahy, S.H. Hwang, J. Yang, L.M. Mahakian, H. I. Wettersten, J.Y. Liu, Y. Wang, E.S. Ingham, S. Tam, M.W. Kieran, R.H. Weiss, K.W. Ferrara and B.D. Hammock. 2014 Jul. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci USA. 111(30):11127-32. PMCID: PMC4121808. [Download]
951. Gupta, R., Y. Dong, P.D. Solomon, H. Wettersten, C. Chang, J. Min, J. Henson, S.K. Dogra, S.H. Hwang, B.D. Hammock, L.J. Zhu, R. Reddel, W.M. Saltzman, R.H. Weiss, S. Chang, M.R. Green and N. Wajapeyee. 2014 Jul. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci USA. 111(30):E3062-71. PMCID: PMC4121806. [Download]
952. Wagner K, Yang J, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. J Pain. 2014;15(9):907-14. Epub 2014/06/14. doi: 10.1016/j.jpain.2014.05.008. PubMed PMID: 24924124; PMCID: PMC4150748. [Download]
955. Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Journal of the American Heart Association. 2014;3(4). Epub 2014/08/26. doi: 10.1161/jaha.114.001015. PubMed PMID: 25146704; PMCID: PMC4310392. [Download]
956. Shrestha, A., P.T. Krishnamurthy, P. Thomas, B.D. Hammock and S.H. Hwang. 2014 Sept. Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischemic injury in rats. J Pharm Pharmacol. 66(9):1251-58. PMCID: PMC4134728. [Download]
957. Lee, K.S.S., J.Y. Liu, K. Wagner, S. Pakhomova, H. Dong, C. Morissuea, J. Yang, P. Wang, A. Ulu, C. Mate, L. Nguyen, S.H. Hwang, M. Edin, A. Mara, H. Wulff, M. Newcomer, D. Zeldin and B. D. Hammock. 2014 Aug. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem. 57(16):7016-30. PMCID: PMC4148150. [Download]
959. Terry, C., M.L. Carlson, Y.X. He, H. Li, I. Zhuplatov, A. Ulu, C. Morisseau, D. Blumenthal, B.D. Hammock and A.K. Cheung. 2014 Sept. Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model. J Vasc Res. 51(4):269-282. [Download]
962. Xu, J., C. Morisseau and B.D. Hammock. 2014 Aug. Expression and characterization of an epoxide hydrolase from Anopheles gambiae with high activity on epoxy fatty acids. Insect Biochem Mol Biol. 54C:42-52. [Download]
963. Kim, J., J. Imig, B.D. Hammock and B. Padanilam. 2014 Oct. Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. Am J Physiol Renal Physiol. 307(8):F971-80. [Download]
964. Ono, E., S. Dutile, S. Kazani, M.E. Wechsler, J. Yang, B.D. Hammock, Y. Tabet, M. Sirois, C. Sirois, E. Rizcallah, É. Rousseau, E. Israel, B.D. Levy , B.T. Ameredes, E. Bleecker, W.J. Calhoun, R. Cherniack, V.M. Chinchilli, T.J. Craig, L. Denlinger, E. DiMango, J. Fahy, N. Icitovic, N.N. Jarjour, T.S. King, M. Kraft, S.C. Lazarus, R.F. Lemanske, S. Peters, J. Ramsdell, R.A. Smith, C.A. Sorkness, S.J. Szefler, M.J. Walter, S. Wasserman and National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network. 2014 Oct. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med. 190(8):886-97. [Download]
966. Piomelli, D., A, Hohmann, V. Seybold and B.D. Hammock. 2014 Nov. A lipid gate for the peripheral control of pain. J Neurosci. 34(46):15184-91. [Download]
967. Bettaieb, A., S. Chahed, G. Tabet, J. Yang, C. Morisseau, S. Griffey, B.D. Hammock and F.G. Haj.2014 Nov. Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PLoS One. 9(11):e113019. PMID: 25402489. [Download]
968. Schebb, N.H., A.I. Ostermann, J. Yang, B.D. Hammock, A. Hahn and J.P. Schuchardt. 2014. Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipons. Prostaglandins Other Lipid Mediat. 113-115(2014):21-29. PMID: 24880049. [Download]
969. Wang, W., J. Zhu, D. Lyu, D. Panigrahy, K.W. Ferrara and B.D. Hammock and G. Zhang. 2014. ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat. 113-115(2014):13-20. PMID: 25019221. [Download]
970. Samokhvalov, V., I. Zlobine, K.L. Jamieson, P. Jurasz, K.S.S. Lee, B.D. Hammock and J.M. Seubert. 2014. PPARγ signaling mediates the cytotoxicity of DHA in H9C2 cells. Toxicol Lett. 232(1):10-20. PMID: 25300478. [Download]
971. Wagner, K., S. Vito, B. Inceoglu and B.D. Hammock. 2014. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins Other Lipid Mediat. 113-115(2014):2-12. PMID: 25240260. [Download]
972. Flannery, B.M., J.L. Silverman, D.A. Bruun, K.R. Puhger, M.R. McCoy, B.D. Hammock, J.N. Crawley and P.J. Lein. 2014. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicol Teratol. 47C:36-45. PMID: 25446016. [Download]
973. Vito, S.T., C.N. Banks, A.T. Austin, B. Inceoglu, D.A. Bruun, D. Zolkowska, D.J. Tancredi, M.A. Rogawski, B.D. Hammock and P.J. Lein. 2014. Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. Toxicol Appl Pharmacol. 281(2):185-194. PMID: 25448683. [Download]
974. Yueh, M.F., K. Taniguchi, S. Chen, R.M. Evans, B.D. Hammock, M. Karin and R.H. Tukey. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci USA. 111(48):17200-05. PMID: 25404284. [Download]
975. Sporkova, A., S. Jichova, Z. Huskova, L. Kopkan, A. Nishiyama, S.H. Hwang, B.D. Hammock, J. Imig, E. Kompanowska-Jezierska, J. Sadowski, H. Kramer and L. Cervenka. 2014. Different mechanisms of acute versus long term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clin Exp Pharmacol Physiol. 41(12):1003-1013. PMID: 25224811. [Download]
976. Yang, J., J. Bratt, L. Franzi, J.Y. Liu, G. Zhang, A.A. Zeki, C.F.A. Vogel, K. Williams, H. Dong, Y.P. Lin, S.H. Hwang, N. Kenyon, B.D. Hammock. 2015 Jan. Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 52(1):46-55. [Download]
977. Wecksler,A.T., S.H. Hwang, J.Y. Liu, H.I. Wettersten, C. Morisseau, J. Wu, R.H. Weiss and B.D. Hammock. 2015 Jan. Biological Evaluation of a Novel Sorafenib Analogue, t-CUPM. Cancer Chemother Pharmacol. 75(1):161-71. [Download]