1106. Deng BQ, Luo Y, Kang X, Li CB, Morisseau C, Yang J, Lee KSS, Huang J, Hu DY, Wu MY, Peng A, Hammock BD, Liu JY. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3beta signaling. Proc Natl Acad Sci U S A. 2017;114(47):12608-13. Epub 2017/11/08. doi: 10.1073/pnas.1705615114. PubMed PMID: 29109264; PMCID: PMC5703276. [Download]

1107. Lakkappa N, Krishnamurthy PT, Yamjala K, Hwang SH, Hammock BD, Babu B. Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development. J Pharm Biomed Anal. 2018;149:457-64. Epub 2017/11/24. doi: 10.1016/j.jpba.2017.11.043. PubMed PMID: 29169114; PMCID: PMC5843369. [Download]

1108. Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mos J, Awwad K, Fromel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Muller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I. Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature. 2017;552(7684):248-52. Epub 2017/12/07. doi: 10.1038/nature25013. PubMed PMID: 29211719. [Download]

1109. Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan CX. COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin. Molecular cancer therapeutics. 2017. Epub 2017/12/30. doi: 10.1158/1535-7163.Mct-16-0818. PubMed PMID: 29284644. [Download]

1110. Burmistrov V, Morisseau C, Harris TR, Butov G, Hammock BD. Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability. Bioorganic chemistry. 2017;76:510-27. Epub 2018/01/09. doi: 10.1016/j.bioorg.2017.12.024. PubMed PMID: 29310082. [Download]

1111. Kodani SD, Bhakta S, Hee Hwang S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 2018. doi: https://doi.org/10.1016/j.bmcl.2018.01.003[Download]

1112. Guedes A, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Hwang SH, Morisseau C, Hammock B. Evaluation of soluble epoxide hydrolase inhibition in experimentally induced radiocarpal synovitis in horses. Veterinary anaesthesia and analgesia. 2017;44(1):195.e11-.e12. doi: 10.1016/j.vaa.2016.12.053. [Download]

1113. Pecic S, Zeki AA, Xu X, Jin GY, Zhang S, Kodani S, Halim M, Morisseau C, Hammock BD, Deng S-X. Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability. Prostaglandins & Other Lipid Mediators. 2018. doi: https://doi.org/10.1016/j.prostaglandins.2018.02.004[Download]

1114. Hao L, Kearns J, Scott S, Wu D, Kodani SD, Morisseau C, Hammock BD, Sun X, Wang S, Zhao L. Indomethacin enhanced brown fat activity. J Pharmacol Exp Ther. 2018. Epub 2018/03/24. doi: 10.1124/jpet.117.246256. PubMed PMID: 29567865.[Download]

1115. Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC. Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Scientific Reports. 2018;8(1):5279. doi: 10.1038/s41598-018-23504-1. [Download]

1117. Minaz N, Razdan R, Hammock BD, Goswami SK. An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats. Prostaglandins Other Lipid Mediat. 2018;136:84-9. Epub 2018/05/12. doi: 10.1016/j.prostaglandins.2018.05.004. PubMed PMID: 29751149.[Download]

1118. Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy. J Med Chem. 2018;61(9):4271. Epub 2018/04/28. doi: 10.1021/acs.jmedchem.8b00582. PubMed PMID: 29701466; PMCID: PMC5949719. [Download]

1119. Burmistrov V, Morisseau C, Pitushkin D, Karlov D, Fayzullin RR, Butov GM, Hammock BD. Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2018. Epub 2018/05/29. doi: 10.1016/j.bmcl.2018.05.024. PubMed PMID: 29803731. [Download]

1121. Wang W, Yang J, Zhang J, Wang Y, Hwang SH, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu JY, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proc Natl Acad Sci U S A. 2018;115(20):5283-8. Epub 2018/05/03. doi: 10.1073/pnas.1721711115. PubMed PMID: 29717038; PMCID: PMC5960306. [Download]

1122. Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. 2018. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proc Natl Acad Sci U S A. 115(25):E5815-e23. doi: 10.1073/pnas.1802179115. PMCID: PMC6016799. [Download]

1126. Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury. Mol Pharmacol. 2018. Epub 2018/05/31. doi: 10.1124/mol.118.111831. PubMed PMID: 29844231. [Download]

1127. Napimoga MH, Rocha EP, Trindade-da-Silva CA, Demasi APD, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption. Journal of periodontal research. 2018. Epub 2018/06/01. doi: 10.1111/jre.12559. PubMed PMID: 29851077. [Download]

1128. Bastan I, Ge XN, Dileepan M, Greenberg YG, Guedes AG, Hwang SH, Hammock BD, Washabau RJ, Rao SP, Sriramarao P. Inhibition of soluble epoxide hydrolase attenuates eosinophil recruitment and food allergen-induced gastrointestinal inflammation. Journal of leukocyte biology. 2018. Epub 2018/01/19. doi: 10.1002/jlb.3ma1017-423r. PubMed PMID: 29345370. [Download]

1129. Yang Y-M, Sun D, Kandhi S, Froogh G, Zhuge J, Huang W, Hammock BD, Huang A. Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation. Proceedings of the National Academy of Sciences. 2018;115(3):613-8. doi: 10.1073/pnas.1716016115. [Download]

1131. Fang X, Cai W, Cheng Q, Ai D, Wang X, Hammock BD, Zhu Y, Zhang X. Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern. Prostaglandins & Other Lipid Mediators. 2018;139:1-9. doi: https://doi.org/10.1016/j.prostaglandins.2018.09.002[Download]

1133. Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. ACS Omega. 2018;3(10):14076-86. doi: 10.1021/acsomega.8b01625. [Download]

1136. Burmistrov V, Morisseau C, D’yachenko V, Rybakov VB, Butov GM, Hammock BD. Fluoroaromatic fragments on 1,3-disubstituted ureas enhance soluble epoxide hydrolase inhibition. Journal of Fluorine Chemistry. 2019. doi: https://doi.org/10.1016/j.jfluchem.2019.02.005[Download]

1137. Hrdlicka J, Neckár J, Papoušek F, Husková Z, Kikerlová S, Vanourková Z, Vernerová Z, Akat F, Vašinová J, Hammock BD, Hwang SH, Imig JD, Falck JR, Cervenka L, Kolár F. Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats. Frontiers in pharmacology. 2019;10(159). doi: 10.3389/fphar.2019.00159. [Download]

1138. Luo Y, Wu MY, Deng BQ, Huang J, Hwang SH, Li MY, Zhou CY, Zhang QY, Yu HB, Zhao DK, Zhang G, Qin L, Peng A, Hammock BD, Liu JY. 2019. Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK. Proc Natl Acad Sci U S A. 116(11):5154-9. doi: 10.1073/pnas.1815746116. PMCID: PMC6421466. [Download]

1139. Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K. 2019. Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation. Proc Natl Acad Sci U S A. 116(14):7083-8. doi: 10.1073/pnas.1819234116. PMCID: PMC6452650. [Download]

1141. Liu Z-B, Sun C-P, Xu J-X, Morisseau C, Hammock BD, Qiu F. Phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition: Kinetics and interaction mechanism merged with simulations. International Journal of Biological Macromolecules. 2019. doi: https://doi.org/10.1016/j.ijbiomac.2019.04.055[Download]

1142. Rand AA, Helmer PO, Inceoglu B, Hammock BD, Morisseau C. LC-MS/MS Analysis of the Epoxides and Diols Derived from the Endocannabinoid Arachidonoyl Ethanolamide. Methods in molecular biology (Clifton, NJ). 2018;1730:123-33. Epub 2018/01/25. doi: 10.1007/978-1-4939-7592-1_10. PubMed PMID: 29363071; PMCID: PMC5831730. [Download]

1144. Pardeshi R, Bolshette N, Gadhave K, Arfeen M, Ahmed S, Jamwal R, Hammock BD, Lahkar M, Goswami SK. Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes. Frontiers in pharmacology. 2019;10(288). doi: 10.3389/fphar.2019.00288. [Download]

1147. Wan D, Yang J, McReynolds CB, Barnych B, Wagner KM, Morisseau C, Hwang SH, Sun J, Blöcher R, Hammock BD. In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Frontiers in pharmacology. 2019;10(464). doi: 10.3389/fphar.2019.00464. [Download]

1148. Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV. Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis. 2019. Epub 2019/04/26. doi: 10.1002/elps.201900059. PubMed PMID: 31021001. [Download]

1149. Minaz N, Razdan R, Hammock BD, Mujwar S, Goswami SK. 2019. Impact of diabetes on male sexual function in streptozotocin-induced diabetic rats: Protective role of soluble epoxide hydrolase inhibitor. Biomedicine & Pharmacotherapy. 115:108897. doi: https://doi.org/10.1016/j.biopha.2019.108897[Download]

1150. Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM. 2019. Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver. Frontiers in Pharmacology. 10(580). doi: 10.3389/fphar.2019.00580. [Download]

1151. Lakkappa N, Krishnamurthy PT, M DP, Hammock BD, Hwang SH. 2019. Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease. Neurotoxicology. 70:135-45. doi: 10.1016/j.neuro.2018.11.010. [Download]

1152. McReynolds CB, Hwang SH, Yang J, Wan D, Wagner K, Morisseau C, Li D, Schmidt WK, Hammock BD. 2019. Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis. Frontiers in Pharmacology. 10(533). doi: 10.3389/fphar.2019.00533.[Download]

1153. Blocher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. 2018. Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. J Med Chem. 61(8):3541-50. doi: 10.1021/acs.jmedchem.7b01804. PMCID: PMC5933862. [Download]

1154. de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS. 2019. Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei. Mol Biol Rep. 46(1):371-9. doi: 10.1007/s11033-018-4481-4. PMCID: PMC6426676. [Download]

1155. Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP. 2019. Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. The Journal of Clinical Investigation. 129(7). doi: 10.1172/JCI127282. [Download]

1156. Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. 2017. Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem. 49:8-14. doi: 10.1016/j.jnutbio.2017.07.006. PMCID: PMC5858941. [Download]

1157. Li J, Zhou Y, Wang H, Gao Y, Li L, Hwang SH, Ji X, Hammock BD. 2017. COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor. Oncotarget. 8(50):87353-63. doi: 10.18632/oncotarget.20928. PMCID: PMC5675638. [Download]

1160. Swardfager W, Hennebelle M, Yu D, Hammock BD, Levitt AJ, Hashimoto K, Taha AY. 2018. Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target. Neurosci Biobehav Rev. 87:56-66. doi: 10.1016/j.neubiorev.2018.01.010. PMCID: PMC5860823. [Download]

1161. Cervenka L, Huskova Z, Kopkan L, Kikerlova S, Sedlakova L, Vanourkova Z, Alanova P, Kolar F, Hammock BD, Hwang SH, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckar J. 2018. Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension. J Hypertens. 36(6):1326-41. doi: 10.1097/hjh.0000000000001708. [Download]

1162. Yamanashi H, Boeglin WE, Morisseau C, Davis RW, Sulikowski GA, Hammock BD, Brash AR. 2018. Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function. J Lipid Res. 59(4):684-95. doi: 10.1194/jlr.M082701. PMCID: PMC5880498. [Download]

1163. Martinez JA, Yang J, Wertheim BC, Roe DJ, Schriewer A, Lance P, Alberts DS, Hammock BD, Thompson PA. 2018. Celecoxib use and circulating oxylipins in a colon polyp prevention trial. PLoS One. 13(4):e0196398. doi: 10.1371/journal.pone.0196398. PMCID: PMC5919576. [Download]

1165. Certikova Chabova V, Kujal P, Skaroupkova P, Varnourkova Z, Vackova S, Huskova Z, Kikerlova S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesar V, Cervenka L. 2018. Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease. Kidney Blood Press Res. 43(2):329-49. doi: 10.1159/000487902. PMCID: PMC5985203. [Download]

1168. Zarriello S, Tuazon JP, Corey S, Schimmel S, Rajani M, Gorsky A, Incontri D, Hammock BD, Borlongan CV. 2019. Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders. Prog Neurobiol. 172:23-39. doi: 10.1016/j.pneurobio.2018.11.001. [Download]

1171. Hiesinger K, Wagner KM, Hammock BD, Proschak E, Hwang SH. 2019. Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity. Prostaglandins Other Lipid Mediat. 140:31-9. doi: 10.1016/j.prostaglandins.2018.12.003. PMCID: PMC6345559. [Download]

1172. Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD. 2019. Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif). Anal Chim Acta. 1057:106-13. doi: 10.1016/j.aca.2018.12.060. PMCID: PMC6426448. [Download]

1173. Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2019. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proc Natl Acad Sci U S A. 116(5):1698-703. doi: 10.1073/pnas.1803999116. PMCID: PMC6358686. [Download]

1174. Zhu M, Wang L, Wu X, Na R, Wang Y, Li QX, Hammock BD. 2019. A novel and simple imidazo[1,2-a]pyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish. Anal Chim Acta. 1058:155-65. doi: 10.1016/j.aca.2019.01.023. [Download]

1175. Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih PB, Lee KSS, Minter LM, Kim D, Xiao H, Liu JY, Hammock BD, Zeldin DC, Zhang G. 2019. Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis. Cancer Res. 79(8):1822-30. doi: 10.1158/0008-5472.Can-18-3221. PMCID: PMC6467714. [Download]

1176. de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MVB, Chambergo FS. 2019. The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. Int J Biol Macromol. 129:653-8. doi: 10.1016/j.ijbiomac.2019.02.070. PMCID: PMC6447457. [Download]

1177. Beals E, Kamita SG, Sacchi R, Demmer E, Rivera N, Rogers-Soeder TS, Gertz ER, Van Loan MD, German JB, Hammock BD, Smilowitz JT, Zivkovic AM. 2019. Addition of milk fat globule membrane-enriched supplement to a high-fat meal attenuates insulin secretion and induction of soluble epoxide hydrolase gene expression in the postprandial state in overweight and obese subjects. J Nutr Sci. 8:e16. doi: 10.1017/jns.2019.11. PMCID: PMC6498758. [Download]

1179. Matsumoto N, Kataoka M, Hirosaki H, Morisseau C, Hammock BD, Suzuki E, Hasumi K. 2019. N-Substituted amino acid inhibitors of the phosphatase domain of the soluble epoxide hydrolase. Biochem Biophys Res Commun. 515(1):248-53. doi: 10.1016/j.bbrc.2019.05.088. [Download]

1180. Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner K, Hammock BD, Proschak E. 2019. Computer-Aided Selective Optimization of Side Activities of Talinolol. ACS Medicinal Chemistry Letters. 10(6):899-903. doi: 10.1021/acsmedchemlett.9b00075. [Download]

1181. Klocke J, Ulu A, Wu K, Rudolph B, Dragun D, Gollasch M, Schunck W-H, Hammock BD, Riemekasten G, Enghard P. 2019. Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice. Scientific Reports. 9(1):8993. doi: 10.1038/s41598-019-45299-5. [Download]

1184. Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX. 2019. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer’s Signaling in Human Nerve Cells. ACS Chemical Neuroscience. 10.1021/acschemneuro.9b00271. [Download]

1185. Lee KSS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. 2019. Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways. ACS Central Science. 10.1021/acscentsci.9b00770. [Download]

1186. Codony S, Valverde E, Leiva R, Brea J, Isabel Loza M, Morisseau C, Hammock BD, Vázquez S. 2019. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry. 27(20):115078. https://doi.org/10.1016/j.bmc.2019.115078[Download]

1187. Shen Y, Peng W, Chen Q, Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X. 2019. Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. Brain, Behavior, and Immunity. 81:535-544. https://doi.org/10.1016/j.bbi.2019.07.014[Download]

1188. Joshi U, Pearson A, Evans JE, Langlois H, Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B, Paris D, Hammock B, Vasylieva N, Hongsibsong S, Stern LJ, Crawford F, Mullan M, Abdullah L. 2019. A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness. Brain, Behavior, and Immunity. 81:545-559. https://doi.org/10.1016/j.bbi.2019.07.015[Download]

1189. Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe DS, Kumar NG, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao SP. 2019. Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. Frontiers in Pharmacology. 10(1118). 10.3389/fphar.2019.01118. [Download]

1192. Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knoll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. 2019. Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. J Med Chem. 62(18):8443-8460. 10.1021/acs.jmedchem.9b00445. [Download]

1195. Yang J, Bruun DA, Wang C, Wan D, Reynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol.114749. 10.1016/j.taap.2019.114749. [Download]

1196. Atone J, Wagner K, Hashimoto K, Hammock B. 2019. Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases. Prostaglandins & Other Lipid Mediators.106385. https://doi.org/10.1016/j.prostaglandins.2019.106385. [Download]

1198. Otoki Y, Metherel AH, Pedersen T, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY. 2020. Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. Lipids. 55(1):7-22. 10.1002/lipd.12197. [Download]

1199. Zhang CY, Duan JX, Yang HH, Sun CC, Zhong WJ, Tao JH, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX. 2019. COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence. Febs j. 10.1111/febs.15105. [Download]

 

1200.  Wagner KM, Atone J, Hammock BD. 2019. Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models. Brain Research.146573. https://doi.org/10.1016/j.brainres.2019.146573. [Download]

1201. Burmistrov V, Morisseau C, D'Yachenko V, Karlov D, Butov GM, Hammock BD. 2020. Imidazolidine-2,4,5- and pirimidine-2,4,6-triones – New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility. Bioorganic & Medicinal Chemistry Letters. 30(3):126908. https://doi.org/10.1016/j.bmcl.2019.126908. [Download]

1202. Sun CP, Zhang J, Zhao WY, Yi J, Yan JK, Wang YL, Morisseau C, Liu ZB, Hammock BD, Ma XC. 2020. Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics. Bioorganic chemistry. 96:103637. 10.1016/j.bioorg.2020.103637. [Download]

1203. Liu G, Wu F, Jiang X, Que Y, Qin Z, Hu P, Lee KSS, Yang J, Zeng C, Hammock BD, Tong X. 2020. Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase. British Journal of Pharmacology. 10.1111/bph.14937. [Download]

1206.Singh N, Hammock BD. 2020. Soluble Epoxide Hydrolase. In: Offermanns S, Rosenthal W, editors. Encyclopedia of Molecular Pharmacology. Cham: Springer International Publishing; 2020. p. 1-7.DOI:https://doi.org/10.1007/978-3-030-21573-6_10020-1. [Download

 

1207. Stefanovski D, Shih P-aB, Hammock BD, Watanabe RM, Youn JH. 2020. Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach. Prostaglandins & Other Lipid Mediators. 148:106410. https://doi.org/10.1016/j.prostaglandins.2020.106410.PMID: 31931080; PMCID requested by journal. [Download] 

1208. Rand AA, Rajamani A, Kodani SD, Harris TR, Schlatt L, Barnych B, Passerini AG, Hammock BD. 2019. Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2. Journal of Lipid Research. 60(12):1996-2005. [Download] 

1210. Panigrahy D, Gilligan MM, Huang S, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD. 2020. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?Cancer Metastasis Rev.1-4. 10.1007/s10555-020-09889-4. PMCID: PMC7207990. [Download

1211. Huerta-Yepez S, Tirado-Rodriguez A, Montecillo-Aguado MR, Yang J, Hammock BD, Hankinson O. 2020. Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Scientific reports. 10(1):7843. 10.1038/s41598-020-64146-6. [Download] 

1212.Edin ML, Lih FB, Hammock BD, Thomson S, Zeldin DC, Bishop-Bailey D. 2020. Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids. Cells. 9(5). 10.3390/cells9051096. [Download] 

1213. Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, Xiong Z, Zhang J, Tan Y, Wang X, Fujita Y, Ishima T, Wang D, Hwang SH, Hammock BD, Hashimoto K. 2020. Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase. Proceedings of the National Academy of Sciences. 117(21):11753. 10.1073/pnas.1922287117. [Download

1214. Wu N, Hammock B, Lee KSS, An G. 2020. Simultaneous Target-Mediated Drug Disposition (TMDD) Model for Two Small-Molecule Compounds Competing for Their Pharmacological Target: Soluble Epoxide Hydrolase. J Pharmacol Exp Ther. 10.1124/jpet.120.265330. [Download

 

1215.Wang Y, Yang J, Wang W, Sanidad KZ, Cinelli MA, Wan D, Hwang SH, Kim D, Lee KSS, Xiao H, Hammock BD, Zhang G. 2020. Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. Proceedings of the National Academy of Sciences. 117(15):8431. 10.1073/pnas.1916189117. [Download

1216. Barnych B, Singh N, Negrel S, Zhang Y, Magis D, Roux C, Hua X, Ding Z, Morisseau C, Tantillo DJ, Siegel JB, Hammock BD. 2020. Development of potent inhibitors of the human microsomal epoxide hydrolase. European Journal of Medicinal Chemistry. 193:112206. https://doi.org/10.1016/j.ejmech.2020.112206. [Download

1217.Trindade-da-Silva CA, Clemente-Napimoga JT, Abdalla HB, Rosa SM, Ueira-Vieira C, Morisseau C, Verri Jr WA, Montalli VAM, Hammock BD, Napimoga MH. 2020. Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model. The FASEB Journal. n/a(n/a). 10.1096/fj.202000415R. [Download

 

1218. Zhang J, Tan Y, Chang L, Hammock BD, Hashimoto K. 2020. Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain -liver axis. J Affect Disord. 270:131-134. 10.1016/j.jad.2020.03.070. PMCID: PMC7243919. [Download

1220. Goswami SK, Yang GY, Gomes A, Hammock BD. 2019. Novel Approaches to Manage Toxicity of Diclofenac in the Gastrointestinal Tract.In: Yiannakopoulou E, editor. Diclofenac: Pharmacology, Uses and Adverse Effects.Nova Science Publishers; 2019. Chapter 7, p. 125-161.ISBN: 978-1-53616-322-3 (ebook), Library of Congress Control Number: 2019950423. [Download

 

1221. Goswami SK, Yang GY, Tiwari S, Hammock BD,Gomes A. 2019. Mitochondrial and Proteasomal Dysfunction as a Possible Mechanism of Cardiovascular Toxicity of Diclofenac. In: Yiannakopoulou E, editor. Diclofenac: Pharmacology, Uses and Adverse Effects.Nova Science Publishers; 2019. Chapter 8, p. 163-175. ISBN: 978-1-53616-322-3 (ebook), Library of Congress Control Number: 2019950423. [Download] 

1224. Hammock BD, Wang W, Gilligan MM, Panigrahy D. 2020. Eicosanoids: the Overlooked Storm in COVID-19? The American Journal of Pathology. https://doi.org/10.1016/j.ajpath.2020.06.010. PMID: 32650004; PMCID: PMC7340586. [Download]

1226. Teixeira JM, Abdalla HB, Basting RT, Hammock BD, Napimoga MH, Clemente-Napimoga JT. 2020. Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats. International Immunopharmacology. 87:106841. PMID: 32736189. https://doi.org/10.1016/j.intimp.2020.106841. [Download]

1227. Burmistrov V, Morisseau C, Karlov D, Pitushkin D, Vernigora A, Rasskazova E, Butov GM, Hammock BD. 2020. Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 30(18):127430. PMID: 32736212. PMCID: PMC7494652.  https://doi.org/10.1016/j.bmcl.2020.127430. [Download]

1230. Codony S, Pujol E, Pizarro J, Feixas F, Valverde E, Loza MI, Brea JM, Saez E, Oyarzabal J, Pineda-Lucena A, Pérez B, Pérez C, Rodríguez-Franco MI, Leiva R, Osuna S, Morisseau C, Hammock BD, Vázquez-Carrera M, Vázquez S. 2020. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis. Journal of Medicinal Chemistry. 63(17):9237-9257. 10.1021/acs.jmedchem.0c00310. PMID:32787085 [Download]

1232. Sirish P, Thai PN, Lee JH, Yang J, Zhang X-D, Ren L, Li N, Timofeyev V, Lee KSS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young N, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. 2020. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. STEM CELLS Translational Medicine. n/a(n/a). 10.1002/sctm.20-0143. PMID: 32790136. [Download]

1233. Fishbein A, Wang W, Yang H, Yang J, Hallisey VM, Deng J, Verheul SML, Hwang SH, Gartung A, Wang Y, Bielenberg DR, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2020. Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. Proceedings of the National Academy of Sciences.202007412. https://www.pnas.org/cgi/doi/10.1073/pnas.2007412117. PMID:32801214. PMCID:PMC7474612. [Download]

1236. Wagner KM, Gomes A, McReynolds CB, Hammock BD. 2020. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics. 17(3):900-916. 10.1007/s13311-020-00916-4. PMID:32875445. [Download]

1237. Wilt S, Kodani S, Le TNH, Nguyen L, Vo N, Ly T, Rodriguez M, Hudson PK, Morisseau C, Hammock BD, Pecic S. 2020. Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies. Bioorganic chemistry. 103:104165. https://doi.org/10.1016/j.bioorg.2020.104165. PMID:32891856. [Download]

1238. Shihadih DS, Harris TR, Kodani SD, Hwang S-H, Lee KSS, Mavangira V, Hamamoto B, Guedes A, Hammock BD, Morisseau C. 2020. Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine. Frontiers in Veterinary Science. 7:580. PMID:33005645. PMCID:PMC7479175. [Download]

1239. Wan X, Fujita Y, Chang L, Wei Y, Ma L, Wuyun G, Pu Y, Hammock BD, Hashimoto K. 2020. Lack of rewarding effects of a soluble epoxide hydrolase inhibitor TPPU in mice: Comparison with morphine. PMID: 32896112. Neuropsychopharmacology Reports. n/a(n/a). 10.1002/npr2.12136. [Download]

Abstract. Fishbein A, Hammock BD, Serhan CN, Panigrahy D. 2020. Carcinogenesis: Failure of resolution of inflammation? Pharmacology & Therapeutics.107670. 

https://doi.org/10.1016/j.pharmthera.2020.107670. PMID: 32891711. [Download]

1242. Lee KSS, Ng JC, Yang J, Hwang S-H, Morisseau C, Wagner K, Hammock BD. 2020. Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain. Bioorganic & Medicinal Chemistry. 28(22):115735. https://doi.org/10.1016/j.bmc.2020.115735. PMID: 33007552. [Download]

1244. Matin N, Fisher C, Lansdell TA, Hammock BD, Yang J, Jackson WF, Dorrance AM. 2020. Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion. Microcirculation. n/a(n/a):e12653. 10.1111/micc.12653. PMID:32767848. [Download]

1245. Hildreth K, Kodani SD, Hammock BD, Zhao L. 2020. Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies. The Journal of Nutritional Biochemistry. 86:108484. https://doi.org/10.1016/j.jnutbio.2020.108484. PMID:32827665. PMCID:PMC7606796. [Download]

1246. Overby H, Yang Y, Xu X, Graham K, Hildreth K, Choi S, Wan D, Morisseau C, Zeldin DC, Hammock BD, Wang S, Bettaieb A, Zhao L. 2020. Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity. International Journal of Molecular Sciences. 2020; 21(19):7039. PMID:32987880. PMCID:PMC7582898. [Download]

1247. Knuth MM, Mahapatra D, Jima D, Wan D, Hammock BD, Law M, Kullman SW. 2020. Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific reports. 10(1):16032. 10.1038/s41598-020-72622-2. PMID: 32994480. PMCID: PMC7524799. [Download]

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