1248. Bukhari IA, Alorainey BI, Al-Motrefi AA, Mahmoud A, Campbell WB, Hammock BD. 2020. 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor, lowers L-NAME-induced hypertension through suppression of angiotensin-converting enzyme in rats. Eur Rev Med Pharmacol Sci. 24(15):8143-8150. 10.26355/eurrev_202008_22501. PMID: 32767352. PMCID: PMC7990106. [Download]

1249. An G, Lee KSS, Yang J, Hammock BD. 2020. Target-Mediated Drug Disposition—A Class Effect of Soluble Epoxide Hydrolase Inhibitors. The Journal of Clinical Pharmacology. n/a(n/a). 10.1002/jcph.1763. PMID: 33078430. PMCID: PMC7969377. [Download]

1250. Maolin Tu, Weicang Wang, Bruce D. Hammock, Guodong Zhang. 2020. ω-3 polyunsaturated fatty acids on colonic inflammation and colon cancer: roles of lipid metabolizing enzymes involved. Nutrients. 10.3390/nu12113301. PMID: 33126566. PMCID: PMC7693568. [Download]

1251. McReynolds C, Morisseau C, Wagner K, Hammock B. 2020. Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation. Adv Exp Med Biol. 1274:71-99. 10.1007/978-3-030-50621-6_5. PMID: 32894508. PMCID: PMC7737916. [Download]

1254. Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KSS, Hammock BD, Bazinet RP, Taha AY. 2019. Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time. Journal of lipid research. 60(3):671-682. 10.1194/jlr.D084228. PMID: 30463986. PMCID: PMC6399504. [Download]


1255. Xia R, Sun L, Liao J, Li H, You X, Xu D, Yang J, Hwang SH, Jones RD, Hammock B, Yang GY. 2019. Inhibition of Pancreatic Carcinoma Growth Through Enhancing ω-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase. Anticancer Res. 39(7):3651-3660. 10.21873/anticanres.13513. PMCID: PMC7117872. [Download]


1256. Vatanparast M, Ahmed S, Lee D-H, Hwang SH, Hammock B, Kim Y. 2020. EpOMEs act as immune suppressors in a lepidopteran insect, Spodoptera exigua. Scientific reports. 10(1):20183. 10.1038/s41598-020-77325-2. PMID: 33214688. PMCID: PMC7677322. [Download]

1257. Griñán-Ferré C, Codony S, Pujol E, Yang J, Leiva R, Escolano C, Puigoriol-Illamola D, Companys-Alemany J, Corpas R, Sanfeliu C, Pérez B, Loza MI, Brea J, Morisseau C, Hammock BD, Vázquez S, Pallàs M, Galdeano C. 2020. Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease. Neurotherapeutics. 10.1007/s13311-020-00854-1. PMID: 32488482. PMCID: PMC7851240. [Download]


1258.Ghosh A, Comerota MM, Wan D, Chen F, Propson NE, Hwang SH, Hammock BD, Zheng H. 2020. An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease. Science Translational Medicine. 12(573):eabb1206. 10.1126/scitranslmed.abb1206. NIHMS ID: 1655166. PMCID: PMC7784555. [Download]


1259.Singh N, Barnych B, Morisseau C, Wagner KM, Wan D, Takeshita A, Pham H, Xu T, Dandekar A, Liu J-Y, Hammock BD. 2020. N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain. Journal of Natural Products. 10.1021/acs.jnatprod.0c00938. PMID: 33320645. PMCID: PMC7888481. [Download]


1260. Pressly B, Lee RD, Barnych B, Hammock BD, Wulff H. 2021. Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the α2β3γ2 GABA-A Receptor. Molecular Pharmacology. 99(1):78-91. 10.1124/molpharm.120.000090. PMID: 33109687. PMCID: PMC7746976. [Download]


1261. Hashimoto K, Hammock BD. 2021. Reply to Reeves and Dunn: Risk for autism in offspring after maternal glyphosate exposure. Proceedings of the National Academy of Sciences. 118(2):e2016496118. 10.1073/pnas.2016496118. PMID: 33443192. PMCID: PMC7812790. [Download]

1263. Sun C-P, Zhang X-Y, Morisseau C, Hwang SH, Zhang Z-J, Hammock BD, Ma X-C. 2021. Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products. Journal of Medicinal Chemistry. 64(1):184-215. 10.1021/acs.jmedchem.0c01507. PMID: 33369424. PMCID: PMC7942193. [Download]

1264. Hammock BD, McReynolds CB, Wagner K, Buckpitt A, Cortes-Puch I, Croston G, Lee KSS, Yang J, Schmidt WK, Hwang SH. 2021. Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative. Journal of Medicinal Chemistry. 10.1021/acs.jmedchem.0c01886. PMCID: PMC7917437. [Download]

1265. Wang Y, Wagner KM, Morisseau C, Hammock BD. 2021. Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence. J Pain Res. 2021;14:61-72. PMID: 33488116. PMCID: PMC7814236. https://doi.org/10.2147/JPR.S241893[Download]

1267. Wang L, Zhao D, Tang L, Li H, Liu Z, Gao J, Edin ML, Zhang H, Zhang K, Chen J, Zhu X, Wang D, Zeldin DC, Hammock BD, Wang J, Huang H. 2021. Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy. Journal of Molecular and Cellular Cardiology. 154:80-91. PMID: 33378686. PMCID: PMC8068623. https://doi.org/10.1016/j.yjmcc.2020.12.013[Download]

1268. Pressly B, Vasylieva N, Barnych B, Singh V, Singh L, Bruun DA, Hwang SH, Chen Y-J, Fettinger JC, Johnnides S, Lein PJ, Yang J, Hammock BD, Wulff H. 2020. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice. Archives of Toxicology. 94(6):1995-2007. 10.1007/s00204-020-02728-z. PMID: 32239239. PMCID: PMC7303059. [Download]

1269. Greite R, Derlin K, Hensen B, Thorenz A, Rong S, Chen R, Hellms S, Jang MS, Bräsen JH, Meier M, Willenberg I, Immenschuh S, Haller H, Luft FC, Panigrahy D, Hwang SH, Hammock BD, Schebb NH, Gueler F. 2020. Early antihypertensive treatment and ischemia-induced acute kidney injury. Am J Physiol Renal Physiol. 319(4):F563-f570. 10.1152/ajprenal.00078.2020. PMCID: PMC7642887. [Download]

1270. Sun C-C, Zhang C-Y, Duan J-X, Guan X-X, Yang H-H, Jiang H-L, Hammock BD, Hwang SH, Zhou Y, Guan C-X, Liu S-K, Zhang J. 2020. PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice. Biochemical and Biophysical Research Communications. 523(4):1020-1026. https://doi.org/10.1016/j.bbrc.2019.12.131. PMID: 31973813. PMCID: PMC7990110. [Download]

1271. Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW. 2020. Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery. Nat Chem. 12(10):906-913. 10.1038/s41557-020-0530-4. PMID: 32868886. PMCID: PMC7541551. [Download]

1272. Mello A, Hsu MF, Koike S, Chu B, Cheng J, Yang J, Morisseau C, Torok NJ, Hammock BD, Haj FG. 2021. Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease. Cell Mol Gastroenterol Hepatol. 11(3):815-830. 10.1016/j.jcmgh.2020.10.002. PMID: 33068774. PMCID: PMC7851189. [Download]

1275. Xie M, Yang J, Zhang J, Sherman HL, Zhang Z, Minter LM, Hammock BD, Park Y, Zhang G. 2020. Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in Il-10(-/-) Mice. J Agric Food Chem. 68(29):7641-7647. 10.1021/acs.jafc.0c03024. PMID: 32594738. PMCID: PMC7901524. [Download]

1278. Zhang YF, Sun CC, Duan JX, Yang HH, Zhang CY, Xiong JB, Zhong WJ, Zu C, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX. 2020. A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress. Biomed Pharmacother. 126:109907. 10.1016/j.biopha.2020.109907. PMID: 32114358. PMCID: PMC8868492. [Download]

1280. Mo F, Duan S, Jiang X, Yang X, Hou X, Shi W, Carlos CJJ, Liu A, Yin S, Wang W, Yao H, Yu Z, Tang Z, Xie S, Ding Z, Zhao X, Hammock BD, Lu X. 2021. Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy. Signal Transduction and Targeted Therapy. 6(1):80. 10.1038/s41392-021-00462-1. PMID: 33627635. PMCID: PMC7904846. [Download]

1284. Jazebi N, Evans C, Kadaru HS, Kompella D, Fang F, Raji M, Pappolla M, Tang SJ, Chung JM, Hammock BD, Fang X. 2021. HIV-related Neuropathy: Pathophysiology, Treatment, and Challenges. J Neurol Exp Neurosci 7(1): 15-24. doi: 10.17756/jnen.2021-082. PMCID: PMC8896895. [Download]

1285. Jamieson KL, Darwesh AM, Sosnowski DK, Zhang H, Shah S, Zhabyeyev P, Yang J, Hammock BD, Edin ML, Zeldin DC, Oudit GY, Kassiri Z, Seubert JM. 2021. Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury. Int J Mol Sci. 2021 Feb 8;22(4):1691. doi: 10.3390/ijms22041691. PMID: 33567585. PMCID: PMC7915306. [Download]

1286. Singh N, Barnych B, Wagner KM, Wan D, Morisseau C, Hammock BD. 2021. Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug Reduces Endoplasmic Reticulum Stress and Inflammatory Pain. ACS Omega 6 (10), 7165-7174. DOI: 10.1021/acsomega.1c00241. PMCID: PMC7970556. [Download]

1287. McReynolds CB, Cortes-Puch I, Ravindran R, Khan IH, Hammock BG, Shih P-aB, Hammock BD, Yang J. 2021. Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Frontiers in Physiology. 12(403). 10.3389/fphys.2021.663869. PMID: 33868029. PMCID: PMC8047414. [Download]

1289. Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, Hammock BD, Zhu Y. 2019. Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice. Am J Physiol Gastrointest Liver Physiol. 316(4):G527-g538. 10.1152/ajpgi.00148.2018. PMID: 30789748. PMCID: PMC6483021. [Download]

1290. Codony S, Calvó-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Pérez C, Rodríguez-Franco MI, Pizarro-Delgado J, Corpas R, Griñán-Ferré C, Pallàs M, Sanfeliu C, Vázquez-Carrera M, Hammock BD, Feixas F, Vázquez S. 2021. From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis. Journal of Medicinal Chemistry. 10.1021/acs.jmedchem.0c01601. PMID: 33945278. PMCID: PMC8634379. [Download]

1291. Morisseau C, Kodani SD, Kamita SG, Yang J, Lee KS, Hammock BD. 2021. Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. International Journal of Molecular Sciences. 22(9). 10.3390/ijms22094993. PMID: 34066758. PMCID: PMC8125816. [Download]

1293. Mavangira V, Kuhn MJ, Abuelo A, Morisseau C, Hammock BD, Sordillo LM. 2021. Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis. Antioxidants. 10(5). 10.3390/antiox10050812. PMID: 34065244. PMCID: PMC8161397. [Download]

1294. Baek SJ, Hammock BD, Hwang I-K, Li Q, Moustaid-Moussa N, Park Y, Safe S, Suh N, Yi S-S, Zeldin DC, Zhong Q, Bradbury JA, Edin ML, Graves JP, Jung H-Y, Jung Y-H, Kim M-B, Kim W, Lee J, Li H, Moon J-S, Yoo I-D, Yue Y, Lee J-Y, Han H-J. 2021. Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop. Nutrients. 13(6):1881. PMID: 34072678. PMCID: PMC8227583. [Download]

1295. Jonnalagadda D, Wan D, Chun J, Hammock BD, Kihara Y. 2021. A Soluble Epoxide Hydrolase Inhibitor, 1-TrifluoromethoxyPhenyl-3-(1-Propionylpiperidin-4-yl) Urea, Ameliorates Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 22(9). 10.3390/ijms22094650. PMID: 33925035. PMCID: PMC8125305. [Download]

1296. Koike S, Hsu MF, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG. 2021. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss. Free Radic Biol Med. 10.1016/j.freeradbiomed.2021.05.029. [Download]

1297. Wang S, Ishima T, Qu Y, Shan J, Chang L, Wei Y, Zhang J, Pu Y, Fujita Y, Tan Y, Wang X, Ma L, Wan X, Hammock BD, Hashimoto K. 2021. Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain–gut–microbiota axis via the subdiaphragmatic vagus nerve. Journal of Affective Disorders. 292:565-573. https://doi.org/10.1016/j.jad.2021.06.006. PMID: 34147969. PMCID: PMC8282729. [Download]

1299. Du F, Sun W, Morisseau C, Hammock BD, Bao X, Liu Q, Wang C, Zhang T, Yang H, Zhou J, Xiao W, Liu Z, Chen G. 2021. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. European Journal of Medicinal Chemistry. 223:113678. https://doi.org/10.1016/j.ejmech.2021.113678. PMID: 34218083. PMCID: PMC8877601. [Download]

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1300. Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I. 2021. EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. eLife. 10:e68445. 10.7554/eLife.68445. PMID: 34342583. PMCID: PMC8331186. [Download]


1301. Ravindran R, McReynolds C, Yang J, Hammock BD, Ikram A, Ali A, Bashir A, Zohra T, Chang WLW, Hartigan-O’Connor DJ, Rashidi HH, Khan IH. 2021. Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses. PLOS ONE. 16(7):e0254367. 10.1371/journal.pone.0254367. PMID: 34242356. PMCID: PMC8270414. [Download]


1304. Khan MAH, Hwang SH, Barnett SD, Stavniichuk A, Jankiewicz WK, Hammock BD, Imig JD. 2021. Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats. British Journal of Pharmacology. n/a(n/a). https://doi.org/10.1111/bph.15623. PMID: 34255857. PMCID: PMC8863090. [Download]

1305. Tiwari S, Yang J, Morisseau C, Durbin-Johnson B, Hammock BD, Gomes AV. 2021. Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Scientific reports. 11(1):7042. 10.1038/s41598-021-86284-1. PMID: 33782432. PMCID: PMC8007717. [Download]


1306. Yang Y, Xu X, Wu H, Yang J, Chen J, Morisseau C, Hammock BD, Bettaieb A, Zhao L. 2021. Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice. Int J Mol Sci. 22(15). 10.3390/ijms22158267. PMID: 34361032. PMCID: PMC8347952. [Download]


1307. Sun C-P, Zhang X-Y, Zhou J-J, Huo X-K, Yu Z-L, Morisseau C, Hammock BD, Ma X-C. 2021. Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β signaling pathway. Food and Chemical Toxicology. 156:112516. https://doi.org/10.1016/j.fct.2021.112516. PMID: 34411643. PMCID: PMC8889936. [Download]


1308.  McReynolds CB, Yang J, Guedes A, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner K, Hammock BD. 2021. Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development. Molecules. 26(16). 10.3390/molecules26165034. PMID: 34443621. PMCID: PMC8399023. [Download]


1309. Fang Y, Johnson H, Anderl JL, Muchamuel T, McMinn D, Morisseau C, Hammock BD, Kirk C, Wang J. 2021. Role of epoxide hydrolases and cytochrome P450s on metabolism of KZR-616, a first-in-class selective inhibitor of the immunoproteasome. Drug Metabolism and Disposition.DMD-AR-2020-000307. 10.1124/dmd.120.000307. PMID: 34234005. [Download]


1310. Du F, Cao R, Chen L, Sun J, Shi Y, Fu Y, Hammock BD, Zheng Z, Liu Z, Chen G. 2021. Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain. Acta Pharmaceutica Sinica B. https://doi.org/10.1016/j.apsb.2021.09.018. PMID: 35530144. PMCID: PMC9072249. [Download]


1311. Deng J, Yang H, Haak VM, Yang J, Kipper FC, Barksdale C, Hwang SH, Gartung A, Bielenberg DR, Subbian S, Ho K-K, Ye X, Fan D, Sun Y, Hammock BD, Panigrahy D. 2021. Eicosanoid regulation of debris-stimulated metastasis. Proceedings of the National Academy of Sciences. 118(41):e2107771118. 10.1073/pnas.2107771118. PMID: 34607951. PMCID: PMC8521662. [Download]

1313.   Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad M, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. 2021. Chronic Diclofenac Exposure Increases Mitochondrial Oxidative Stress, Inflammatory Mediators, and Cardiac Dysfunction. Cardiovasc Drugs Ther. 10.1007/s10557-021-07253-4. PMID: 34499283. PMCID: PMC8904649. [Download]

1314. Bergmann CB, Hammock BD, Wan D, Gogolla F, Goetzman H, Caldwell CC, Supp DM. 2021. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Scientific reports. 11(1):16555. 10.1038/s41598-021-96014-2. PMID: 34400718. PMCID: PMC8368302. [R35 ES030443, P42 ES004699]. EH [Download]

1317.  Wilt S, Kodani S, Valencia L, Hudson PK, Sanchez S, Quintana T, Morisseau C, Hammock BD, Kandasamy R, Pecic S. 2021. Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorganic & Medicinal Chemistry. 51:116507. https://doi.org/10.1016/j.bmc.2021.116507. PMID: 34794001. PMCID: PMC8900675. [Download

1316. Gowler PRW, Turnbull J, Shahtaheri M, Gohir S, Kelly T, McReynolds C, Jun Y, Jha RR, Fernandes GS, Zhang W, Doherty M, Walsh DA, Bruce HD, Valdes AM, Barrett DA, Chapman V. 2021. Clinical and preclinical evidence for roles of soluble epoxide hydrolase in osteoarthritis knee pain. Arthritis Rheumatol. 10.1002/art.42000. PMID: 34672113. PMCID: PMC8957539. [Download]

1318. Singh N, Vik A, Lybrand DB, Morisseau C, Hammock BD. 2021. New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation. Chemical Research in Toxicology. 10.1021/acs.chemrestox.1c00347. PMID: 34817988. PMCID: PMC8853703. [Download]

1319. Xu J, Qiu X, Yu G, Ly M, Yang J, Silva RM, Zhang X, Yu M, Wang Y, Hammock B, Pinkerton KE, Zhao D. 2022. Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats. Toxicology. 465:153045. PMID: 34801612. PMCID: PMC9484547. https://doi.org/10.1016/j.tox.2021.153045. [Download]

1321. Martín-López J, Codony S, Bartra C, Morisseau C, Loza MI, Sanfeliu C, Hammock BD, Brea J, Vázquez S. 2021. 2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity. Pharmaceuticals. 14(12). 10.3390/ph14121323. PMID: 34959721; PMCID: PMC8703317. [Download]

1322. Wagner KM, Yang J, Morisseau C, Hammock BD. 2021. Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation. Frontiers in Pharmacology. 12:3373. PMID: 34975481; PMCID: PMC8719166. [Download]

1323. Zhao Z, Zhang C, Lin J, Zheng L, Li H, Qi X, Huo H, Lou X, Hammock BD, Hwang SH, Bao Y, Luo M. 2021. COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl4-Induced Liver Fibrosis and Portal Hypertension. Frontiers in Medicine. 8. 10.3389/fmed.2021.761517. PMID: 35004731; PMCID: PMC8734593. [Download]


1325. Jankiewicz WK, Barnett SD, Stavniichuk A, Hwang SH, Hammock BD, Belayet JB, Khan AH, Imig JD. 2021. Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity. Frontiers in Pharmacology. 12. 10.3389/fphar.2021.744776. PMID: 34955823; PMCID: PMC8695932. [Download]


1326. Wan D, Morisseau C, Hammock BD, Yang J. 2022. A Fast and Selective Approach for Profiling Vicinal Diols Using Liquid Chromatography-Post Column Derivatization-Double Precursor Ion Scanning Mass Spectrometry. Molecules. 27(1):283. PMID: 35011515; PMCID: PMC8747065. [Download]

1331. Ulu A, Velazquez JV, Burr A, Sveiven SN, Yang J, Bravo C, Hammock BD, Nordgren TM. 2022. Sex-Specific Differences in Resolution of Airway Inflammation in Fat-1 Transgenic Mice Following Repetitive Agricultural Dust Exposure. Front Pharmacol. 2022 Jan 13;12:785193. doi: 10.3389/fphar.2021.785193. PMID: 35095496; PMCID: PMC8793679. [Download]

1332. Sun CP, Zhou JJ, Yu ZL, Huo XK, Zhang J, Morisseau C, Hammock BD, Ma XC. 2022. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2118818119. doi: 10.1073/pnas.2118818119. PMID: 35217618. PMCID: PMC8892522. [Download]

1333. Leuillier M, Duflot T, Ménoret S, Messaoudi H, Djerada Z, Groussard D, Denis RGP, Chevalier L, Karoui A, Panthu B, Thiébaut P-A, Schmitz-Afonso I, Nobis S, Campart C, Henry T, Sautreuil C, Luquet SH, Beseme O, Féliu C, Peyret H, Nicol L, Henry J-P, Renet S, Mulder P, Wan D, Tesson L, Heslan J-M, Duché A, Jacques S, Ziegler F, Brunel V, Rautureau GJP, Monteil C, do Rego J-L, do Rego J-C, Afonso C, Hammock B, Madec A-M, Pinet F, Richard V, Anegon I, Guignabert C, Morisseau C, Bellien J. 2022. CRISPR/Cas9-mediated Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Prevents Obesity and Cardiac Ischemic Injury. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2022.03.004 [Download]

1334. Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. 2022. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease. Journal of Medicinal Chemistry. 65(6):4909-4925. 10.1021/acs.jmedchem.1c02150. PMID: 35271276. PMCID: PMC8958510. [Download]

1336. Bergmann Christian B, McReynolds Cindy B, Wan D, Singh N, Goetzman H, Caldwell Charles C, Supp Dorothy M, Hammock Bruce D. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proceedings of the National Academy of Sciences. 119(13):e2120691119. 10.1073/pnas.2120691119. PMID: 35312372. PMCID: PMC9060469. [Download]

1337. Abdalla HB, Napimoga MH, Teixeira JM, Trindade-da-Silva CA, Pieroni VL, Dos Santos Araújo FSM, Hammock BD, Clemente-Napimoga JT. 2022. Soluble epoxide hydrolase inhibition avoid formalin-induced inflammatory hyperalgesia in the temporomandibular joint. Inflammopharmacology. 2022 Mar 18. doi: 10.1007/s10787-022-00965-5. Epub ahead of print. PMID: 35303234. [Download]


1338. Zhang C, Li W, Li X, Wan D, Mack S, Zhang J, Wagner K, Wang C, Tan B, Chen J, Wu CW, Tsuji K, Takeuchi M, Chen Z, Hammock BD, Pinkerton KE, Yang J. 2022. Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor. PLoS One. 2022 Apr 20;17(4):e0266608. doi: 10.1371/journal.pone.0266608. PMID: 35443010; PMCID: PMC9020733. [Download]

1339. Singh N, Li D, McReynolds CB, Morisseau C, Hammock BD. 2022. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer. Analytical Methods. 10.1039/D2AY00272H. PMID: 35481804. PMCID: PMC9116231. [Download]

1340. Edin ML, Lih FB, Hammock BD, Thomson S, Zeldin DC, Bishop-Bailey D. 2020. Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids. Cells. 9(5):1096. PMID: 32365470. PMCID: PMC7290345. [Download]

1341. Montecillo-Aguado M, Tirado-Rodriguez B, AntonioAndres G, Morales-Martinez M, Tong Z, Yang J, Hammock BD, Hernandez-Pando R, Huerta-Yepez S. 2022. Omega-6 Polyunsaturated Fatty Acids Enhance Tumor Aggressiveness in Experimental Lung Cancer Model: Important Role of Oxylipins. Int. J. Mol. Sci. 2022, 23, 6179. https://doi.org/10.3390/ ijms23116179. PMID: 35682855. PMCID: PMC9181584. [Download]

1343. Matsumoto N, Singh N, Lee KS, Barnych B, Morisseau C, Hammock BD. 2022. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms. Prostaglandins & Other Lipid Mediators. 162:106662. https://doi.org/10.1016/j.prostaglandins.2022.106662. [Download]

1346. Burmistrov V, Morisseau C, Babkov DA, Golubeva T, Pitushkin D, Sokolova EV, Vasipov V, Kuznetsov Y, Bazhenov SV, Novoyatlova US, Bondarev NA, Manukhov IV, Osipova V, Berberova N, Spasov AA, Butov GM, Hammock BD. 2022. Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety. International Journal of Molecular Sciences. 2022, 23, 10710. https://www.mdpi.com/1422-0067/23/18/10710#cite. [Download]

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