Esterase and Amidase

11.  Hammock, B.D. and G.B. Quistad.  1976.  The degradative metabolism of juvenoids by insects.  In: The Juvenile Hormones, (Gilbert, L.E., eds.), Plenum Press, New York, pp. 374-393. [Download]

014.  Hammock, B.D., T.C. Sparks and S.M. Mumby.  1977.  Selective inhibition of JH esterases from cockroach hemolymph.  Pestic. Biochem. Physiol.  7:517-530. [Download]

022.  Mumby, S.M., B.D. Hammock, T.C. Sparks and K. Ota.  1979.  Synthesis and bioassay of carbamate inhibitors of the juvenile hormone hydrolyzing esterases from the housefly, Musca domestica.  J. Agric. Food Chem.  27(4):763-765. [Download]

044.  Sparks, T.C. and B.D. Hammock.  1980.  Comparative inhibition of the juvenile hormone esterases from Trichoplusia ni, Tenebrio molitor, and Musca domestica. Pestic. Biochem. Physiol.  14:290-302. [Download]

046.  Hammock, B.D. and G.B. Quistad.  1981.  Metabolism and mode of action of juvenile hormone, juvenoids, and other insect growth regulators.  In: Progress in Pesticide Biochemistry, (Hutson, D.H. and T.R. Roberts, eds.), John Wiley & Sons, Ltd., Sussex, England, pp. 1-83, Volume 1. [Download]

053.  Hammock, B.D., K.D. Wing, J. McLaughlin, V.M. Lovell and T.C. Sparks.  1982.  Trifluoromethylketones as possible transition state analog inhibitors of juvenile hormone esterase.  Pestic. Biochem. Physiol.  17:76-88. [Download]

067.  Sparks, T.C. and B.D. Hammock.  1983.  Insect growth regulators: resistance and the future.  In: Pest Resistance to Pesticides: Challenges and Prospects, (Georghiou, G.P. and T. Saito, eds.), pp. 615-668, Plenum Press, New York. [Download]

071.  Prestwich, G.D., W.-S. Eng, R.M. Roe and B.D. Hammock.  1984.  Synthesis and bioassay of isoprenoid 3-alkylthio-1,1,1-trifluoro-2- propanones: potent, selective inhibitors of juvenile hormone esterase.  Arch. Biochem. Biophys.  228(2):639-645. [Download]

074.  Hammock, B.D., Y.A.I. Abdel-Aal, C.A. Mullin, T.N. Hanzlik and R.M. Roe.  1984.  Substituted thiotrifluoropropanones as potent selective inhibitors of juvenile hormone esterase.  Pestic. Biochem. Physiol.  22:209-223. [Download]

079.  Abdel-Aal, Y.A.I. and B.D. Hammock.  1985.  3-Octylthio-1,1,1-trifluoro-2-propanone, a high affinity and slow binding inhibitor of juvenile hormone esterase fromTrichoplusia ni (Hübner).  Insect Biochem.  15(1):111-122. [Download]

083.  Abdel-Aal, Y.A.I. and B.D. Hammock.  1985.  Use of transition-state theory in the development of bioactive molecules.  In: Bioregulators for Pest Control, (Hedin, P.A., eds.), pp. 135-160, ACS Symposium Series 276, ACS Publications, Washington D.C. [Download]

104.  Abdel-Aal, Y.A.I. and B.D. Hammock.  1986.  Transition state analogs as ligands for affinity purification of juvenile hormone esterase.  Science.  233:1073-1076. [Download]

105.  Hammock, B.D., Y.A.I. Abdel-Aal, M. Ashour, A. Buhler, T.N. Hanzlik, R. Newitt and T.C. Sparks.  1986.  Paradigms for the discovery of new insect control agents. In: Human Welfare and Pest Control Chemicals-Approaches to Safe and Effective Control of Medical and Agricultural Pests, (Sasa, M., S. Matsunaka, I. Yamamoto and K. Ohsawa, eds.), pp. 53-72, Proceedings: XVIII Pesticide Science Symposium and Public Lectures, October 1985, Nissan Science Foundation, Pesticide Science Society of Japan, Tokyo, Japan. [Download]

114.  Hammock, B.D., Y.A.I. Abdel-Aal, T.N. Hanzlik, G.E. Croston and R.M. Roe.  1987.  Affinity purification and characteristics of juvenile hormone esterase from Lepidoptera.  In: Molecular Entomology, (Law, J.H., eds.), pp. 315-328, UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 49, Alan R. Liss, Inc., New York. [Download]

116.  Munger, C.E., G.W. Ivie, R.J. Christopher, B.D. Hammock and T.D. Phillips. 1987. Acetylation/deacetylation reactions of T-2, acetyl T-2, HT-2 and acetyl HT-2 toxins in bovine rumen fluid in vitro. J. Agric. Food Chem.  35(3):354-358. [Download]

120.  Ashour, M.-B.A. and B.D. Hammock.  1987.  Substituted trifluoroketones as potent, selective inhibitors of mammalian carboxylesterases.  Biochem. Pharmacol. 36(12):1869-1879. [Download]

121.  Ashour, M.-B.A., D.E. Moody and B.D. Hammock.  1987.  Apparent induction of microsomal-carboxylesterase activities in tissues of clofibrate-fed mice and rats. Toxicol. Appl. Pharmacol.  89:361-369. [Download]

124.  Hanzlik, T.N. and B.D. Hammock.  1987.  Characterization of affinity-purified juvenile hormone esterase from Trichoplusia ni.  J. Biol. Chem.  262(28):13584-13591. [Download]

127.  Ashour, M.-B.A., S.J. Gee and B.D. Hammock.  1987.  Use of a 96-well microplate reader for measuring routine enzyme activities.  Anal. Biochem.  166:353-360. [Download]

129.  Olmstead, M.M., W.K. Musker and B.D. Hammock.  1987.  Structure of the hydrate form of a b-thiotrifluoromethyl ketone, a potent esterase inhibitor.  Acta Cryst. C43:1726-1728. [Download]

130.  Ashour, M.-B.A., L.G. Harshman and B.D. Hammock.  1987.  Malathion toxicity and carboxylesterase activity in Drosophila melanogaster.  Pestic. Biochem. Physiol. 29:97-111. [Download]

131.  Ottea, J.A., F.W. Plapp and B.D. Hammock.  1987.  Biochemical and genetic analysis of epoxide-metabolizing enzymes in susceptible and resistant house flies,Musca domestica L.  Pestic. Biochem. Physiol.  29:138-145. [Download]

137.  Moody, D.E., G.A. Clawson, D.A. Geller, L.A. Taylor, J. Button, D.N. Loury, B.D. Hammock and E.A. Smuckler.  1988.  Sodium cholate extraction of rat liver nuclear xenobiotic-metabolizing enzymes.  Biochem. Pharmacol.  37(7):1331-1341. [Download]

139.  Abdel-Aal, Y.A.I., T.N. Hanzlik, B.D. Hammock, L.G. Harshman and G. Prestwich.  1988.  Juvenile hormone esterases in two Heliothines: Kinetic, biochemical and immunogenic characterization.  Comp. Biochem. Physiol.  90B(1):117-124. [Download]

141.  Ottea, J.A., L.G. Harshman and B.D. Hammock.  1988.  Novel assay for determining the metabolic fate of juvenile hormone III: A study with Drosophila melanogaster.  Arch. Insect Biochem. Physiol.  8:25-37. [Download]

158.  Székács, A., B.D. Hammock, Y.A.I. Abdel-Aal, P.P. Halarnkar, M. Philpott and G. Matolcsy.  1989.  New trifluoropropanone sulfides as highly active and selective inhibitors of insect juvenile hormone esterase.  Pestic. Biochem. Physiol.  33:112-124. [Download]

168.  Székács, A., B. Bordás, G. Matolcsy and B.D. Hammock.  1989.  Quantitative structure-activity relationship study of aromatic trifluoromethyl ketones: In vitroinhibitors of insect juvenile hormone esterase.  In: Probing Bioactive Mechanisms, (Magee, P., J. Block and D. Henry, eds.), pp. 169-182, ACS Symposium Series No. 413, American Chemical Society, Washington, D.C. [Download]

169.  Grant, D.F., D.M. Bender and B.D. Hammock.  1989.  Quantitative kinetic assays for glutathione S-transferase and general esterase in individual mosquitoes using an EIA reader.  Insect Biochem.  19(8):741-751. [Download]

170.  Hammock, B.D., A. Székács, T. Hanzlik, S. Maeda, M. Philpott, B. Bonning and R. Possee.  1990.  Use of transition state theory in the design of chemical and molecular agents for insect control.  In: Recent Advances in the Chemistry of Insect Control II, (Crombie, L., ed.), pp. 256-277, Royal Society of Chemistry, Cambridge, U.K. [Download]

172.  Hammock, B.D., B.C. Bonning, R.D. Possee, T.N. Hanzlik and S. Maeda  1990.  Expression and effects of the juvenile hormone esterase in a baculovirus vector. Nature. 344(6265):458-461. [Download]

177.  Székács, A., P.P. Halarnkar, M.M. Olmstead, K.A. Prag and B.D. Hammock. 1990. Heterocyclic derivatives of 3-substituted-1,1,1-trifluoro-2-propanones as inhibitors of esterolytic enzymes.  Chem. Res. Toxicol.  3(4):325-332. [Download]

178.  Harshman, L.G. and B.D. Hammock.  1990.  The use of Drosophila melanogaster for in situ biomonitoring.  In: In Situ Evaluations of the Biological Hazards of Environmental Pollutants., (Sandhu, S.S., W.R. Lower, F.J.d. Serres, W.A. Suk and R.R. Tice, eds.), Plenum Press, New York, pp. 191-194. [Download]

182.  Thomas, T.C., A. Székács, S. Rojas, B.D. Hammock, B.W. Wilson and M.G. McNamee.  1990.  Characterization of neuropathy target esterase using trifluoromethyl ketones.  Biochem. Pharmacol.  40(12):2587-2596. [Download]

188.  DiBiasio, K.W., M.H. Silva, L.R. Shull, J.W. Overstreet, B.D. Hammock and M.G. Miller.  1991.  Xenobiotic metabolizing enzyme activities in rat, mouse, monkey, and human testes.  Drug Metab. Dispos.  19(1):227-232. [Download]

212.  Eldridge, R., D.R. O'Reilly, B.D. Hammock and L.K. Miller.  1992.  Insecticidal properties of genetically engineered baculoviruses expressing an insect juvenile hormone esterase gene.  Appl. Environ. Microbiol.  58(5):1583-1591. [Download]

214.  Székács, A., B. Bordás and B.D. Hammock.  1992.  Transition state analog enzyme inhibitors: Structure-activity relationships of trifluoromethyl ketones.  In: Rational Approaches to Structure, Activity, and Ecotoxicology of Agrochemicals., (Draber, W. and T. Fujita, eds.), CRC Press, Boca Raton, Florida, pp. 219-249. [Download]

224.  Székács, A., S.J. Gee, F. Jung, B.F. McCutchen and B.D. Hammock.  1992.  An affinity-amplified immunoassay for juvenile hormone esterase.  Anal. Biochem. 207:291-297. [Download]

236.  Huang, T.L., S.A. Villalobos and B.D. Hammock.  1993.  Effect of hepatotoxic doses of paracetamol and carbon tetrachloride on the serum and hepatic carboxylesterase activity in mice.  J. Pharm. Pharmacol.  45:458-465. [Download]

238.  Huang, T.L., A. Székács, T. Uematsu, E. Kuwano, A. Parkinson and B.D. Hammock. 1993. Hydrolysis of carbonates, thiocarbonates, carbamates, and carboxylic esters of a-naphthol, b-naphthol, and p-nitrophenol by human, rat, and mouse liver carboxylesterases.  Pharm. Res.  10(5):639-648. [Download]

260.  Thomas, T.C., A. Székács, B.D. Hammock, B.W. Wilson and M.G. McNamee. 1993. Affinity chromatography of neuropathy target esterase.  Chem.-Biol. Interactions.  87:347-360. [Download]

263.  Shiotsuki, T., T.L. Huang, T. Uematsu, B.C. Bonning, V.K. Ward and B.D. Hammock. 1994. Juvenile hormone esterase purified by affinity chromatography with 8-mercapto-1,1,1-trifluoro-2-octanone as a rationally designed ligand.  Protein Expres. Purif.  5:296-306.[Download]

278.  Shiotsuki, T., T.L. Huang and B.D. Hammock.  1994.  Affinity purification of mouse liver carboxylesterase with trifluoromethyl ketones as ligands.  J. Pestic. Sci. 19(4):321-324. [Download]

280.  McCutchen, B.F., A. Székács, T.L. Huang, T. Shiotsuki and B.D. Hammock. 1995. Characterization of a spectrophotometric assay for juvenile hormone esterase. Insect Biochem. Molec. Biol.  25(1):119-126. [Download]

300.  Borhan, B., Y. Ko, C. Mackay, B.W. Wilson, M.J. Kurth and B.D. Hammock. 1995. Development of surrogate substrates for neuropathy target esterase.  Biochim. Biophys. Acta. 1250:171-182. [Download]

305.  Székács, A. and B. Hammock.  1991.  Affinity-amplified immunoassay for the detection of insect juvenile hormone esterase.  Biokémia  15(4):152-153. [Download]

327.  Mackay, C.E., B.D. Hammock and B.W. Wilson.  1996.  Identification and isolation of a 155-kDa protein with neuropathy target esterase activity.  Fundam. Appl. Toxicol. 30(1):23-30. [Download]

332.  Senter, P., H. Marquardt, B. Thomas, B. Hammock, I. Frank and H. Svensson.  1996.  The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs. Cancer Res.  56:1471-1484. [Download]

333.  Borhan, B., B.D. Hammock, J. Seifert and B.W. Wilson.  1996.  Methyl and phenyl esters and thioesters of carboxylic acids as surrogate substrates for microassay of proteinase K esteratic activity.  Fresenius J. Anal. Chem.  354(4):490-492. [Download]

339.  Mackay, C., B.D. Hammock. And B.W. Wilson.  1996.  Identification of a 155 kDa fractin that possesses neuropathy target esterase activity.  In: Enzymes of the Cholinesterase Family, (Quinn, D., A. Balasubramanian, B. Doctor and P. Taylor, eds.), Plenum Press, New York, pp. 387-388. [Download]

347.  Huang, T., T. Shiotsuki, T. Uematsu, B. Borhan, Q. Li and B. Hammock.  1996.  Structure-activity relationships for substrates and inhibitors of mammalian liver microsomal carboxylesterases.  Pharm. Res.  13(10):1495-1500. [Download]

376.  Huang, T.L., and B. D. Hammock.  1997.  Solubilization of mouse liver microsomal carboxylesterases.  Pharmaceutical Sciences.  3:605-608. [Download]

418.  Morisseau, C., M. Derbel, T.R. Lane, D. Stoutamire and B.D. Hammock.  1999.  Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats.  Toxicol. Sci. 52(2):148-153. [Download]

419.  Lakritz, J., B.S. Winder, J. Noorouz-Zadeh, T.L. Huang, A.R. Buckpitt, B.D. Hammock, and C.G. Plopper.  2000.  Hepatic and pulmonary enzyme activities in horses.  Am. J. Vet. Res. 61(2):152-157. [Download]

439.  Wang, G.Y., T.J. Michailides, B.D. Hammock, Y.M. Lee and R.M. Bostock.  2000.  Affinity purification and characterization of a cutinase from the fungal plant pathogen Monilinia fructicola (Wint.) honey.  Arch. Biochem. Biophys.  382(1):31-38. [Download]

440.  Fanucchi, M.V., A.R. Buckpitt, M.E. Murphy, D.H. Storms, B.D. Hammock and C.G. Plopper.  2000.  Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells.  Toxicol. Appl. Pharmacol.  168(3):253-267. [Download]

471.  Shan, G. and B.D. Hammock.  2001.  Development of sensitive esterase assays based on a-cyano containing esters.  Anal Biochem. 299:54-62. [Download]

482.  Harcourt, R.L., I. Horne, T.D. Sutherland, B.D. Hammock, R.J. Russell and J.G. Oakeshott. 2002. Development of a simple and sensitive fluorimetric method for isolation or coumaphos-hydrolysing bacteria.  Lett. Appl. Microbiol. 34:263.268. [Download]

489.  Wheelock, C.E., T.F. Severson and B.D. Hammock.  2001.  Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility.  Chem. Res. Toxicol. 14(12):1563-1572. [Download]

507.  Denton, D.L., C.E. Wheelock, S.A. Murray, L.A. Deanovic, B.D. Hammock and D.E. Hinton.  2003.  Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas).  Environ. Toxicol. Chem. 22:336-341. [Download]

509.  Wheelock, C.E., M.E. Colvin, I. Uemura, M.M. Olmstead, J.R. Sanborn, Y. Nakagawa, A.D. Jones and B.D. Hammock.  2002.  Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors.  J. Med. Chem. 45:5576-5593. [Download]

517.  Zhang, R., K-D. Kang, G. Shan and B.D. Hammock.  2003.  Design, synthesis and evaluation of novel P450 fluorescent probes bearing ?-cyanoether. Tetrahedron Letts. 44:4331-4334. [Download]

518.  Wheelock, C.E., Å.M. Karlsson, R. Zhang, J.E. Stok, C. Morisseau, S.E. Le Valley, C.E. Green, and B.D. Hammock.  2003.  Evaluation of a-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes.  Anal. Biochem. 315:208-222. [Download]

550.  Stok, J.E., A. Goloshchapov, C. Song, C.E. Wheelock, M.B.H. Derbel, C. Morisseau and B.D. Hammock.  2004.  Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis.  Arch. Biochem. Biophys.  430:247-255. [Download]

553.  Wheelock, C.E., J.L. Miller, M.J. Miller, S. Gee, G. Shan and B.D. Hammock. 2004. Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity.  Environ. Toxicol. Chem.  23:2699-2708. [Download]

582.  Wheelock, C.E., J.L. Miller, M.J. Miller, B.M. Phillip, S.J. Gee, R.S. Tjeerdema and B.D. Hammock.  2005.  Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca.  Aquat. Toxicol.  74:47-52. [Download]

583.  Kang, K.-D., P.D. Jones, H. Huang, R. Zhang, L.A. Mostovich, C.E. Wheelock, T. Watanabe, L.F. Gulyaeva and B.D. Hammock.  2005.  Evaluation of a-cyano ethers as fluorescent substrates for assay of cytochrome P450 enyzme activity.  Anal. Biochem. 344:183-192. [Download]

588.  Huang, H., C.D. Fleming, K. Nishi, M.R. Redinbo and B.D. Hammock. 2005.  Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases.  Chem. Res. Toxicol.  18:1371-1377. [Download]

596.  Nishi, K., H. Huang, S.G. Kamita, I.-H. Kim, C. Morisseau and B.D. Hammock. 2006. Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2.  Arch. Biochem. Biophys.  445:115-123. [Download]

609.  Wheelock, C.E., J.L. Miller, M.J. Miller, B.M. Phillips, S.A. Huntley, S.J. Gee, R.S. Tjeerdema and B.D. Hammock.  2006.  Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations.  Environ. Toxicol. Chem.  25:973-984. [Download]

610.  Wogulis, M., C.E. Wheelock, S.G. Kamita, A.C. Hinton, P.A. Whetstone, B.D. Hammock and D.K. Wilson.  2006.  Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta.  Biochemistry. [Download]

639.  Wadkins, R.M., J.L. Hyatt, C.C. Edwards, L. Tsurkan, M.R. Redinbo, C.E. Wheelock, P.D. Jones, B.D. Hammock and P.M. Potter.  2007.  Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.  Mol. Pharmacol.  71:713-723. [Download]

643. Huang, H., K. Nishi, H.-J. Tsai and B.D. Hammock.  2007.  Development of highly sensitive fluorescent assays for fatty acid amide hydrolase.  Anal. Biochem. 363:12-21. [Download]

669.  McAbee, R.D., K.-D. Kang, M.A. Stanich, J.A. Christiansen, C.E. Wheelock, A.D. Inman, B.D. Hammock and A.J. Cornel.  2004.  Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California.  Pest Manag. Sci.  60:359-368.  doi:10.1002/ps.799 [Download]

676.  Wheelock, C.E., K. Nishi, A. Ying, P.D. Jones, M.E. Colvin, M. Olmstead and B.D. Hammock.  2008.  Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).  Bioorgan. Med. Chem.  16:2114-2130.  doi:10.1016/j.bmc.2007.10.081 [Download]

705.  Wheelock, C.E., B.M. Phillips, B.S. Anderson, J.L. Miller, M.J. Miller and B.D. Hammock. 2008. Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs). In: Reviews of Environmental Contamination and Toxicology. (Whitacre, D.M. ed.), Springer, New York, Vol. 195, pp. 117-178. [Download]

740.  Morisseau, C., O. Merzlikin, A. Lin, G. He, W. Feng, I. Padilla, M.S. Denison, I.N. Pessah and B.D. Hammock. 2009. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environmental Health Perspectives 117(12):1867-1872. [Download]

771.  Rayo, J., L. Muñoz, G. Rosell, B.D. Hammock, A. Guerrero, F.J. Luque and R. Pouplana. 2010. Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study. J. Mol. Model. 16(11):1753-1764. [Download]