HAMMOCK LAB
The Laboratory of Pesticide Biotechnology
597. Gomez, G.A., C. Morisseau, B.D. Hammock and D.W. Christianson. 2006. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Sci. 15:58-64. PMCID: PMC1762130. [Download]
598. Imig, J.D., X. Zhao, C.Z. Zaharis, J.J. Olearczyk, D.M. Pollock, J.W. Newman, I.-H. Kim, T. Watanabe and B.D. Hammock. 2005. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension. 46:975-981. PMCID: PMC1444888. [Download]
600. Watanabe, T., D. Schulz, C. Morisseau and B.D. Hammock. 2006. High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC/MS/MS analysis. Anal. Chimica Acta. 559:37-44. PMCID: PMC1447531. [Download]
601. Huang, H., K. Nishi, S.J. Gee and B.D. Hammock. 2006. Evaluation of chiral ?-cyanoesters as general fluorescent substrates for screening enantioeselective esterases. J. Agr. Food Chem. 54:694-699. [Download]
602. Shearer, G.C., J.W. Newman, B.D. Hammock and G.A. Kaysen. 2005. Graded effects of proteinuria on HDL structure in nephrotic rats. J. Am. Soc. Nephrol. 16:1309-1319. PMCID: PMC1444886. [Download]
604. Davis, B.B., C. Morisseau, J.W. Newman, T.L. Pedersen, B.D. Hammock and R.H. Weiss. 2006. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. J. Pharmacol. Exp. Ther. 316:815-821. PMCID: PMC1456012. [Download]
605. Harris, T.R., C. Morisseau, R.L. Walzem, S.J. Ma and B.D. Hammock. 2006. The cloning and characterization of a soluble epoxide hydrolase in chicken. Poultry Sci. 85:278-287. PMCID: PMC1764503. [Download]
607. Larsen, B.T., H. Miura, O.A. Hatoum, W.B. Campbell, B.D. Hammock, D.C. Zeldin, J.R. Falck and D.D. Gutterman. 2006. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKCa channels: implications of soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol. 290:491-499. PMCID: PMC 1456013. [Download]
612. Lee, C.R., K.E. North, M.S. Bray, M. Fornage, J.M. Seubert, J.W. Newman, B.D. Hammock, D.J. Couper, G. Heiss and D.C. Zeldin. 2006. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The atherosclerosis risk in communities (ARIC) study. Hum. Mol. Genet. 15:1640-1649. PMCID: PMC2040335. [Download]
614. Carkeet, C., S.R. Dueker, J. Lango, B.A. Buchholz, J.W. Miller, R. Green, B.D. Hammock, J.R. Roth and P.J. Anderson. 2006. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin. Proc Natl Acad Sci U S A. 103(15):5694-99. PMID: 16585531. PMCID: PMC1458635. [Download]
616. Wolf, N.M., C. Morisseau, P.D. Jones, B. Hock and B.D. Hammock. 2006. Development of a high throughput screen for soluble epoxide hydrolase inhibition. Anal Biochem. 355:71-80. PMCID: PMC1965403. [Download]
617. Zhao, B., D.S. Baston, B.D. Hammock and M.S. Denison. 2006. Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. J Biochem Molec Toxicol. 20:103-113. PMCID: PMC3032054. [Download]
618. Li, H.-Y., Y. Jin, C. Morisseau, B.D. Hammock and Y.-Q. Long. 2006. The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase. ioorg Med Chem. 14:6586-6592. PMCID: PMC2040075. [Download]
619. Pokreisz, P., I. Fleming, L. Kiss, E. Barbosa-Sicard, B. Fisslthaler, J.R. Falck, B.D. Hammock, I.-H. Kim, Z. Szelid, P. Vermeersch, H. Gillijns, M. Pellens, F. Grimminger, A.-J. van Zonneveld, D. Collen, R. Busse and S. Janssens. 2006. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension. 47:762-770. PMCID: PMC1993904. [Download]
620. Olearczyk, J.J., M.B. Field, I.-H. Kim, C. Morisseau, B.D. Hammock and J.D. Imig. 2006. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. J Pharmacol Exp Ther. 318(3):1307-1314. PMCID: PMC1892247. [Download]
621. Seubert, J.M., C.J. Sinal, J. Graves, L.M. DeGraff, J.A. Bradbury, C.R. Lee, K. Goralski, M.A. Carey, A. Luria, J.W. Newman, B.D. Hammock, J.R. Falck, H. Roberts, H.A. Rockman, E. Murphy and D.C. Zeldin. 2006. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ. Res. 99:442-450. PMCID: PMC2072806. [Download]
622. Jones, P.D., H.-J. Tsai, Z.N. Do, C. Morisseau and B.D. Hammock. 2006. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 16:5212-5216. PMCID: PMC1904344. [Download]
623. Schmelzer, K.R., A.M. Wheelock, K. Dettmer, D. Morin and B.D. Hammock. 2006. The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways. Environ Health Persp. 114:1354-1360. PMCID: PMC1570074. [Download]
624. Schmelzer, K.R., B. Inceoglu, L. Kubala, I.-H. Kim, S.L. Jinks, J.P. Eiserich and B.D. Hammock. 2006. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci USA. 103:13646-13651. PMCID: PMC1564210. [Download]
625. Morisseau, C., J.W. Newman, H.J. Tsai, P.A. Baecker and B.D. Hammock. 2006. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 16:5439-5444. PMCID: PMC1892215. [Download]
627. Hwang, S.H., C. Morisseau, Z. Do and B.D. Hammock. 2006. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem. 16:5773-5777. PMCID: PMC1904340. [Download]
628. Ng, V.Y., C. Morisseau, J.R. Falck, B.D. Hammock and D.L. Kroetz. 2006. Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor ?-dependent repression of Cyclin D1. Arterioscl. Throm. Vas. 26:2462-2468. PMCID: PMC1904341. [Download]
629. Inceoglu, B., S.L. Jinks, K.R. Schmelzer, T. Waite, I.-H. Kim and B.D. Hammock. 2006. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sci. 79:2311-2319. PMCID: PMC1904345. [Download]
630. Xu, D., N. Li, Y. He, V. Timofeyev, L. Lu, H.-J. Tsai, I.-H. Kim, D. Tuteja, R.K.P. Mateo, A. Singapuri, B. Davis, R. Low, B.D. Hammock and Nipavan Chiamvimonvat. 2006. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci USA. 103:18733-18738. PMCID: PMC1693731. [Download]
631. Kim, I.-H., K. Nishi, H.-J. Tsai, T. Bradford, Y. Koda, T. Watanabe, C. Morisseau, J. Blanchfield, I. Toth and B.D. Hammock. 2007. Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido) dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorg Med Chem. 15:312-323. PMCID: PMC2040326. [Download]
632. Dettmer, K., P.A. Aronov and B.D. Hammock. 2007. Mass spectrometry-based metabolomics. Mass Spectrom. Rev. 26(1):51-78. PMID: 16921475. PMCID: PMC1904337. [Download]
633. Inceoglu, B., K.R. Schmelzer, C. Morisseau, S.L. Jinks and B.D. Hammock. 2007. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Mediat. 82:42-49. PMCID: PMC1904338. [Download]
636. Luria, A., S.M. Weldon, A.K. Kabcenell, R.H. Ingraham, D. Matera, H. Jiang, R. Gill, C. Morisseau, J.W. Newman, B.D. Hammock. 2007. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. J Biol Chem. 282:2891-2898. PMCID: PMC2040337. [Download]
637. Chiappe, C., E. Leandri, B.D. Hammock and C. Morisseau. 2007. Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols. Green Chem. 9:162-168. PMCID: PMC2153531. [Download]
638. Loch, D., A. Hoey, C. Morisseau, B. Hammock and L. Brown. 2007. Prevention of hypertension in DOCA-salt rats by an inhibition of soluble epoxide hydrolase. Cell Biochem Biophys. 47:87-97. PMCID: PMC1892223.. [Download]
641. Akatsuka, T., N. Kobayashi, T. Ishikawa, T. Saito, M. Shindo, M. Yamauchi, K. Kurokohchi, H. Miyazawa, H. Duan, T. Matsunaga, T. Komoda, C. Morisseau and B.D. Hammock. 2007. Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. J Autoimmun. 28:7-18. PMCID: PMC1892246. [Download]
644. Thompson, D.A. and B.D. Hammock. 2007. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst. J Biosci. 32:279-291. PMCID: PMC1904342. [Download]
645. Zhang, W., I.P. Koerner, R. Noppens, M. Grafe, H.J. Tsai, C. Morisseau, A. Luria, B.D. Hammock, J.R. Falck and N. Alkayed. 2007. Soluble epoxide hydrolase: A novel therapeutic target in stroke. J Cereb Blood Flow Metab. 27(12):1931-40. PMCID: PMC2664093. [Download]
646. Ai, D., Y. Fu, D. Guo, H. Tanaka, N. Wang, C. Tang, B.D. Hammock, J.Y-J. Shyy and Y. Zhu. 2007. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci USA. 104:9018-9023. PMCID: PMC1885620. [Download]
647. Wheelock, C.E., S. Goto, B.D. Hammock and J.W. Newman. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics. 3(2):137-145. PMCID: PMC2597807. [Download]
652. Hwang, S.H., H.J. Tsai, J.-Y. Liu, C. Morisseau and B.D. Hammock. 2007. Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 50(16):3825-40. PMCID: PMC2596069. [Download]
653. Endsley, M.P., N. Aggarwal, M.A. Isbell, C.E. Wheelock, B.D. Hammock, J.R. Flack, W.B. Campbell and K. Nithipatikom. 2007. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: location, hydrolysis and 12-lipoxygenase metabolism. Int J Cancer. 121:984-991. PMCID: PMC2565646. [Download]
654. Huang, H., C. Morisseau, J.F. Wang, T. Yang, J.R. Falck, B.D. Hammock and M.-H. Wang. 2007. Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats. Am J Physiol Renal Physiol. 293:342-349. [Download]
655. Newman, J.W., G.A. Kaysen, B.D. Hammock and G.C. Shearer. 2007. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. J Lipid Res. 48(8):1792-1800. [Download]
656. Ahn, K.C., S.J. Gee, H.-J. Kim, M. Nichkova, N.A. Lee and B.D. Hammock. 2007. Progress in the development of biosensors for environmental and human monitoring of agrochemicals. In: Symposium 966: Rational Environmental Management of Agrochemicals: Risk Assessment, Monitoring and Remedial Action: Proceedings of the American Chemical Society Pacifichem 2005, Honolulu, HI (I.R. Kennedy, K. Solomon, S.J. Gee, A. Crossan, S. Wang, F. Sanchez-Bayo eds.), Vol. 966 pp.138-154. ISBN 978-0-8412-7420-4 [Download]
657. Morisseau, C. and B.D. Hammock. 2007. Measurements of soluble epoxide hydrolase (sEH) activity. In: Techniques for analysis of chemical biotransormation. Current Protocols in Toxicology. (J.S. Bus, L.G. Costa, E. Hodgson, D.A. Lawrence and D.J. Reed eds.), John Wiley & Sons, New Jersey. 4.23.1-4.23.18, August, Supplement 33. [Download]
659. Chiamvimonvat, N., C.-M. Ho, H.-J. Tsai and B.D. Hammock. 2007. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Carviovasc Pharmacol. 50:225-237. [Download]
660. Dettmer, K., D. Hanna, P. Whetstone, R. Hansen and B.D. Hammock. 2007. Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory. Anal Bioanal Chem. 388(8):1643-1651. [Download]
661. Devonshire, A.L., R. Heidari, H.Z. Huang, B.D. Hammock, R.J. Russell and J.G. Oakeshott. 2007. Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases from Lucilia cuprina. Insect Biochem Mol Biol. 37:891-902. [Download]
663. Kim, I.H., H.J. Tsai, K. Nishi, T. Kasagami, C. Morisseau and B.D. Hammock. 2007. 1,3-disubstituted ureas functionalized with ether groups and potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. JMedChem. 50(21):5217-5226. PMCID: PMC 2543935. [Download]
664.Park, E.K., S.K. Mak, D. Kultz and B.D. Hammock. 2007. Evaluation of cytotoxicity attributed to thimerosal on murine and human kidney cells. J Toxicol Environ Health A. 70(24):2092-95. [Download]
665. Fleming, I., A. Rueben, R. Popp, B. Fisslthaler, A. Sander, J. Haendeler, J.R. Flack, C. Morisseau, B.D. Hammock and R. Busse. 2007.
Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscl Throm Vas. 27:2612-18. [Download]
666. Vogel, C.F.A., W. Li, E. Sciullo, J. Newman, B.D. Hammock, J.R. Reader, J. Tuscano and F. Matsumura. 2007. Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression. Am J Pathol. 171:1538-1548. PMCID: PMC2043515. [Download]
667. Hillard, C.J., W.-S.V. Ho, J. Thompson, K.M. Gauthier, C.E. Wheelock, H. Huang and B.D. Hammock. 2007. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. Br J Pharmacol. 152:691-698. PMCID: PMC2190024. [Download]
670. Park, E.K., S.K. Mak, D. Kültz and B.D. Hammock. 2008. Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines. J Environ Sci Health B. 43:71-74. [Download]
671. Tanaka, H., S.G. Kamita, N.M. Wolf, T.R. Harris, Z. Wu, C. Morisseau and B.D. Hammock. 2008. Transcriptional regulation of the human soluble expoxide hydrolase gene EPHX2. Biochim Biophys Acta. 1779:17-27. PMCID: PMC2699939. [Download]
672. Anderson, P.J., J. Lango, C. Carkeet, A. Britten, B. Kräutler, B.D. Hammock and J.R. Roth. 2008. One pathway can incorporate either adenine or dimethylbenzimidazole as an a-axial ligand of B12 cofactors in Salmonella enterica. J Bacteriol. 190(4):1160-1171. PMCID: PMC2238215. [Download]
675. Aronova, S., K. Wedman, P.A. Aronov, K. Fontes, K. Ramos, B.D. Hammock and T. Powers. 2008. Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab.7:148-158. [Download]
677. Goodfriend, T.L., T.L. Pedersen, R.J. Grekin, B.D. Hammock, D.L. Ball and A. Vollmer. 2007. Heparin, lipoproteins, and oxygenated fatty acids in blood: A cautionary note. Prostaglandins Leukot Essent Fatty Acids. 77:363-366. PMCID: PMC2705328. [Download]
678. Dreisbach, A.W., J.C. Rice, S. Japa, J.W. Newman, A. Sigel, R.S. Gill, A.E. Hess, A.C. Cemo, J.P. Fonseca, B.D. Hammock, J.J.L. Lertora and L.L. Hamm. 2008. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. Hypertension. 51:755-761. [Download]
679. Chen, J., K.C. Ahn, N.A. Gee, M.I. Ahmed, A.J. Duleba, L. Zhao, S.J. Gee, B.D. Hammock and B.L. Lasley. 2008. Triclocarban enhances testosterone action: A new type of endocrine disruptor? Endocrinology. 149:1173-1179. PMCID: PMC2275366. [Download]
682. Harris, T.R., P.A. Aronov, P.D. Jones, H. Tanaka, M. Arand and B.D. Hammock. 2008. Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules. Arch Biochem Biophys. 472:139-149. PMCID: PMC2435305. [Download]
683. Chawengsub, Y., N.T. Aggarwal, K. Nithipatikom, K.M. Gauthier, S. Anjaiah, B.D. Hammock, J.R. Falck and W.B. Campbell. 2008. Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. Am J Physiol Heart Circ Physiol. 294:1348-1356. [Download]
685. Wheelock, C.E., J. Forshed, S. Goto, B.D. Hammock and J.W. Newman. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chem Res Toxicol. 21:583-590. [Download]
686. Corenblum, M.J., V.E. Wise, K. Georgi, B.D. Hammock, P.A. Doris and M. Fornage. 2008. Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat. Hypertension. 51:567-573. [Download]
687. Morisseau, C., J.W. Newman, C.E. Wheelock, T. Hill III, D. Morin, A.R. Buckpitt and B.D. Hammock. 2008. Development of metabolically stable inhibitors of mammalian microsomal epoxide hydrolase. Chem Res Toxicol. 21:951-957. [Download]
688. Monti, J., J. Fischer, S. Paskas, M. Heinig, H. Schulz, C. Gösele, A. Heuser, R. Fischer, C. Schmidt, A. Schirdewan, V. Gross, O. Hummel, H. Maatz, G. Patone, K. Saar, M. Vingron, S.M. Weldon, K. Lindpaintner, B.D. Hammock, K. Rohde, R. Dietz, S.A. Cook, W.-H. Schunck, F.C. Luft and N. Hubner. 2008. Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat. Genet. 40:529-537. [Download]
689. Morisseau, C. and B.D. Hammock. 2008. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest. Manag. Sci. 64:594-609. [Download]
690. Alihosseini, F., K-S. Ju, J. Lango, B.D. Hammock and G. Sun. 2008. Antibacterial colorants: Characterization of prodiginines and their applications on textile materials. Biotechnol Prog. 24(3):742-747. PMCID: PMC2863012. [Download]
691. Aronov, P.A., L.M. Hall, K. Dettmer, C.B. Stephensen and B.D. Hammock. 2008. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 391:1917-1930. [Download]
692. Jiang, H., A.G. Zhu, M. Mamczur, C. Morisseau, B.D. Hammock, J.R. Falck and J.C. McGiff. 2008. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. J. Pharmacol. Exp. Ther. 326:330-337. [Download]
693. Wheelock, C.E., M.E. Colvin, J.R. Sanborn and B.D. Hammock. 2008. Substituted 3-phenylpropenoates and related analogs: electron ionization mass spectral fragmentation and density functional theory calculations. J. Mass. Spectrom. 43:1053-1062. PMID: 18286670. [Download]
694. Biswal, B.K., C. Morisseau, G. Garen, M.M. Cherney, C. Garen, C. Niu, B.D. Hammock and M.N.G. James. 2008. The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. J. Mol. Biol. 381:897-912. PMID:18585390. PMCID: PMC2866126. [Download]
698. Harris, T.R., N. Li, N. Chiamvimonvat and B.D. Hammock. 2008. The potential of soluble epoxide hydrolase inhibition in the treatment of cardiac hypertrophy. Congest. Heart Fail. 14:209-224. [Download]
699. Harris, T.R., P.A. Aronov and B.D. Hammock. 2008. Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence. DNA Cell Biol. 27(9):467-477. PMID: 18554159. PMCID: PMC2858585. [Download]
702. Ulu, A., B.B. Davis, H-J. Tsai, I-H. Kim, C. Morisseau, B. Inceoglu, O. Fiehn, B.D. Hammock and R.H. Weiss. 2008. Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein E-knockout mouse model. J. Cardiovasc. Pharmacol. 52:314-323. [Download]
703. Fife, K.L., YM. Liu, K.R. Scmhmelzer, H-J. Tsai, I-H. Kim, C. Morisseau, B.D. Hammock and D.L. Kroetz. 2008. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J. Pharmacol. Exper. Therap. 327(3):707-715.
[Download]
706. Inceoglu, B., S.L. Jinks, A. Ulu, C.M. Hegedus, K. Georgi, K.R. Schmelzer, K. Wagner, P.D. Jones, C. Morisseau and B.D. Hammock. 2008. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. PNAS 105(48):18901-18906. [Download]
707. Keserü, B., E. Barbosa-Sicard, R. Popp, B. Fisslthaler, A. Dietrich, T. Gudermann, B.D. Hammock, J.R. Falck, N. Weissmann, R. Busse and I. Fleming. 2008. Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. The FASEB Journal 22:1-10. [Download]
709. Gross, G.J., K.M. Gauthier, J. Moore, J.R. Falck, B.D. Hammock, W.B. Campbell and K. Nithipatikom. 2008. Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. Am. J. Physiol. Heart Circ. Physiol. 294:H2838-H2844. [Download]
710. Olearczyk, J.J., J.E. Quigley, B.C. Mitchell, T. Yamamoto, I-H. Kim, J.W. Newman, A. Luria, B.D. Hammock and J.D. Imig. 2009. Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. Clin. Sci. 116:61-70. [Download]
711. Athirakul, K., J.A. Bradbury, J.P. Graves, L.M. DeGraff, J. Ma, Y. Zhao, J.F. Couse, R. Quigley, D.R. Harder, X. Zhao, J.D. Imig, T.L. Pedersen, J.W. Newman, B.D. Hammock, A.J. Conley, K.S. Korach, T.M. Coffman and D.C. Zeldin. 2008. Increased blood pressure in mice lacking cytochrome P450 2J5. FASEBJ 22:4096-4108. PMCID: PMC2614614. [Download]
712. EnayetAllah, A.E., A. Luria, B. Luo, H-J. Tsai, P. Sura, B.D. Hammock and D.F. Grant. 2008. Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase. J Biol Chem. 283(52):36592-98. PMID: 18974052. PMCID: PMC2605982. [Download]
713. Ai, D., W. Pang, N. Li, M. Xu, P.D. Jones, J. Yang, Y. Zhang, N. Chiamvimonvat, J. Y-J. Shyy, B.D. Hammock and Y. Zhu. 2009. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. PNAS 106(2):564-569. [Download]
714. Rawal, S., C. Morisseau, B.D. Hammock and A.C. Shivachar. 2009. Differential sub cellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes. J. Neurosci. Res. 87:218-227. PMID: 18711743. [Download]
715. Revermann, M., E. Barbosa-Sicard, E. Dony, R.T. Schermuly, C. Morisseau, G. Geisslinger, I. Fleming, B.D. Hammock and R.P. Brandes. 2009. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. J. Hypertension 27(2):322-331. [Download]
718. Liu, J-Y., H-J. Tasi, S.H. Hwang, P.D. Jones, C. Morisseau and B.D. Hammock. 2009. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. British Journal of Pharmacology 156(2):284-296. [Download]
719. Kasagami, T., I-H. Kim, H-J. Tsai, K. Nishi, B.D. Hammock and C. Morisseau. 2009. Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorganic & Medicinal Chemistry Letters 19:1784-1789. [Download]
721. Xie, Y., Y. Lui, G. Gong, D.H. Smith, F. Yan, A. Rinderspacher, Y. Feng, Z. Zhu, X. Ji, S-X. Deng, L. Branden, D. Vidovic, C. Chung, S. Schürer, C. Morisseau, B.D. Hammock and D. W. Landry. 2009. Discovery of potent non-urea inhibitors of soluble epoxide hydroase. Bioorganic & Medicinal Chemistry Letters 19:2354-2359. PMCID: PMC2738751. [Download]
722. Parrish, A.R., G. Chen, R.C. Burghardt, T. Watanabe, C. Morisseau and B.D. Hammock. 2009. Attenuation of cisplatin nephrotoxicity by an inhibition of soluble epoxide hydrolase. Cell. Biol. Toxicol. 25:217-225. PMID: 18386137. PMCID: PMC3033346. [Download]
723. Huang, H., H. Tanaka, B.D. Hammock and C. Morisseau. 2009. Novel and highly sensitive fluorescent assay for leucine aminopeptidases. Analytical Biochemistry 391:11-16. [Download]
724. Simpkins, A.N., R.D. Rudic, D.A. Schreihofer, S. Roy, M. Manhiani, H-J. Tsai, B.D. Hammock and J.D. Imig. 2009. Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection. Amer. J. Pathol. 174(6):2086-2095. [Download]
726. Luria, A., C. Morisseau, H-J. Tsai, J. Yang, B. Inceoglu, B. Taeye, S.M. Watkins, M.M. Wiest, J.B. German and B.D. Hammock. 2009. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am J Physiol Endocrinol Metab. 297:E375-E383. PMCID: PMC2724109. [Download]
727. Liu, J-Y., S-H. Park, C. Morisseau, S. Hwang, B.D. Hammock and R.H. Weiss. 2009. Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol Cancer Ther. 8(6):2193-2203. [Download]
730. Falck, J.R., R. Kodela, R. Manne, K. Atcha, N. Puli, N. Dubasi, V.L. Manthati, J.H. Capdevila, X-Y. Yi, D.H. Goldman, C. Morisseau, B.D. Hammock and W.B. Campbell. 2009. 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates Containing Epoxide Bioisosteres: Influence upon Vascular Relaxation and Soluable Epoxide Hydrolase Inhibition. J. Med. Chem. 52:5069-5075. PMID:19653681. PMCID: PMC2888647. [Download]
731. Shen, S., F. Zhang, S. Zeng, Y. Tian, X. Chai, S. Gee, B.D. Hammock and J. Zheng. 2009. Development of enantioselective polyclonal antibodies to detect styrene oxide protein adducts. Anal. Chem. 81(7):2668-2677. [Download]
732. Matveeva, E.G., C. Morisseau, M.H. Goodrow, C. Mullin and B.D. Hammock. 2009. Tryptophan Fluorescence Quenching by Enzyme Inhibitors As a Tool for Enzyme Active Site Structure Investigation: Epoxide Hydrolase. Current Pharmaceutical Biotechnology. 10(6):589-599. [Download]
733. Manhiani, M., J.E. Quigley, S.F. Knight, S. Tasoobshirazi, T. Moore, M.W. Brands, B.D. Hammock and J.D. Imig. 2009. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Am. J. Physiol. Renal Physiol. 297:F740-F748. PMCID: PMC2739707. [Download]
734. Yang, J., K. Schmelzer, K. Georgi and B.D. Hammock. 2009. Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. Anal. Chem. 81(19):8085-93. PMID:19715299. [Download]
735. Imig, J.D. and B.D. Hammock. 2009. Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nat. Rev. Drug Discov. 8(10):794-805. PMID: 19794443. PMCID: PMC3021468. [Download]
737. Barbosa-Sicard, E., T. Frömel, B. Keserü, R.P. Brandes, C. Morisseau, B.D. Hammock, T. Braun, M. Krüger and I. Fleming. 2009. Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J. Biol. Chem. 284(41):28156-28163. PMCID: PMC2788866. [Download]
738. Lu, C., R. Schoenfeld, Y. Shan, H-J. Tsai, B. Hammock and G. Cortopassi. 2009. Frataxin deficiency induces Schwann cell inflammation and death. Biochimica et Biophysica. 1792:1052-1061. PMID:19679182. [Download]
739. Li, N., J-Y. Liu, V. Timofeyev, H. Qiu, S. Hwang, D. Tuteja, L. Lu, J. Yang, H. Mochida, R. Low, B.D. Hammock and N. Chiamvimonvat. 2009. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. J Mol Cell Cardiol. 47(6):835-845. PMID: 19716829. [Download]
740. Morisseau, C., O. Merzlikin, A. Lin, G. He, W. Feng, I. Padilla, M.S. Denison, I.N. Pessah and B.D. Hammock. 2009. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect. 117(12):1867-1872. PMCID: PMC2799460. [Download]
741. Chawengsub, Y., K.M. Gauthier, K. Nithipatikom, B.D. Hammock, J.R. Falck, D. Narsimhaswamy and W.B. Cambell. 2009. Identification of 13-hydroxy-14, 15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries. J. Biol. Chem. 284(45):31280-31290. PMCID: PMC2781526. [Download]
742. Keserü, B., E. Barbosa-Sicard, R.T. Schermuly, H. Tanaka, B.D. Hammock, N. Weissmann, B. Fisslthaler and I. Fleming. 2010. Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition. Cardiovasc Res. 85(1):232-240. PMCID: PMC2860707. [Download]
743. Lyer, A., D.P. Fairlie, J.B. Prins, B.D. Hammock and L. Brown. 2010. Inflammatory lipid mediators in adipocyte function and obesity. Nat. Rev. Endocrinol. 6(2):71:82. [Download]
744. De Taeye, B.M., C. Morisseau, J. Coyle, J.W. Covington, A. Luria, J. Yang, S.B. Murphy, D.B. Friedman, B.D. Hammock and D.E. Vaughan. 2010. Expression and regulation of soluble epoxide hydrolase in adipose tissue. Obesity (Silver Spring). 18(3):489-98. PMCID: PMC2864128. [Download]
745. Hall, L.M., M.G. Kimlin, P.A. Aronov, B.D. Hammock, J.R. Slusser, L.R. Woodhouse and C.B. Stephensen. 2010. Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J. Nutr. 140(3):542-550. PMCID: PMC2821886. [Download]
748. Chaudhary, K.R., M. Abukhashim, S.H. Hwang, B.D. Hammock and J.M. Seubert. 2010. Inhibition of soluble epoxide hydrolase by trans-4-[4-(3-adamantan-1yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury. J. Cardiovasc. Pharmacol. 55(1):67-73. PMCID: PMC2824072. [Download]
749. Certíková Chábová, V., A. Walkowska, E. Kompanowska-Jezierska, J. Sadowski, P. Kujal, Z. Vernerová, Z. Vanourková, L. Kopkan, H.J. Kramer, J.R. Falck, J.D. Imig, B.D. Hammock, I Vanecková and L. Cervenka. 2010. Combined inhibition of 20-hydroxyeicosatetaenoic acid formation and of epoxyeicosatrienoic acids degration attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clin Sci (Lond). 118(10):617-632. PMCID: PMC2854172. [Download]
750. Liu, J-Y., J. Yang, B. Inceoglu, H. Qiu, A. Ulu, S-H. Hwang, N. Chiamvimonvat and B.D. Hammock. 2010. Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. Biochem Pharmacol. 79(6):880-887. PMCID: PMC3285377. [Download]
751. Bahl, D.C., C. Morisseau, J.M. Bomberger, B.A. Stanton, B.D. Hammock, G.A. O'Toole and D.R. Madden. 2010. Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 192(7):1785-1795. PMCID: PMC2838060. [Download]
753. Alihosseini, F., J. Lango, K-S. Ju, B.D. Hammock and G. Sun. 2010. Mutation of bacterium Vibrio gazogenes for selective preparation of colorants. Biotechnol. Prog. 26(2):352-360. PMCID: PMC2864118. [Download]
754. Townsley, M.I., C. Morriseau, B. Hammock and J.A. King. 2010. Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. Microcirculation 17(2):137-146. PMCID: PMC2923642. [Download]
757. Wang, Y.X., A. Ulu, L.N. Zhang and B.D. Hammock. 2010. Soluble epoxide hydrolase in atherosclerosis. Curr. Atheroscler. Rep. 12(3):174-183. PMID: 20425256. PMCID: PMC2857794. [Download]
758. Kubala, L., K.R. Schmelzer, A. Klinke, H. Kolarova, S. Baldus, B.D. Hammock and J.P. Eiserich. 2010. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. Free Radic. Biol. Med. 48(10):1311-1320. PMCID: PMC2856720. [Download]
760. Revermann, M., M. Schloss, E. Barbosa-Sicard, A. Mieth, S. Liebner, C. Morisseau, G. Geisslinger, R.T. Schermuly, I. Fleming, B.D. Hammock and R.P. Brandes. 2010. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arterioscler. Thromb. Vasc. Biol. 30(5):909-914. PMCID: PMC2919323. [Download]
761. Simpkins, A.N., R.D. Rudic, S. Roy, H.J. Tsai, B.D. Hammock and J.D. Imig. 2009. Soluble epoxide hydrolase inhibition modulates vascular remodeling. Am. J. Physiol. Heart Circ. Physiol. 298(3):H795-H806. PMCID: PMC2838550. [Download]
762. Tsai, H-J., S.H. Hwang, C. Morisseau, J. Yang, P.D. Jones, T. Kasagami, I-H. Kim and B.D. Hammock. 2010. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. Eur. J. Pharm. Sci. 40(3):222-238. PMCID: PMC3285443. [Download]
763. Nording, M.L., J. Yang, C.M. Hegedus, A. Bhushan, N.J. Kenyon, C.E. Davis and B.D. Hammock. 2010. Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor asthma by high-performance liquid chromatography: electrospray tandem mass spectrometry. IEEE Sens J. 10(1):123-130. PMID: 21103452. PMCID: PMC2981865. [Download]
764. Jung, O., F. Jansen, A. Mieth, E. Barbosa-Sicard, R.U. Pliquett, A. Babelova, C. Morisseau, S.H. Hwang, C. Tsai, B.D. Hammock, L. Schaefer, G. Geisslinger, K. Amann and R.P. Brandes. 2010. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. PLoS One 5(8):e11979. PMCID: PMC2915917. [Download]
768. Luo, P., H-H. Chang, Y. Zhou, S. Zhang, S.H. Hwang, C. Morisseau, C-Y. Wang, E.W. Inscho, B.D. Hammock and M.H. Wang. 2010. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. J Pharmacol Exp Ther. 334(2):430-438. PMID: 20439437. PMCID: PMC2913776. [Download]
769. Liu, J-Y., N. Li, J. Yang, N. Li, H. Qiu, D. Ai, N. Chiamvimonvat, Y. Zhu and B.D. Hammock. 2010. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A. 107(39):17017-17022. PMCID: PMC2947894. [Download]
770. Norwood, S., J. Liao, B.D. Hammock and G-Y. Yang. 2010. Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis. Am. J. Transl. Res. 2(4):447-457. PMCID: PMC2923867. [Download]
771. Rayo, J., L. Muñoz, G. Rosell, B.D. Hammock, A. Guerrero, F.J. Luque and R. Pouplana. 2010. Reactivity versus steric effects in flourniated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study. J. Mol. Model. 16(11):1753-1764. PMCID: PMC3014912. [Download]
772. Rose, T.E., C. Morisseau, J-Y. Liu, B. Inceoglu, P.D. Jones, J.R. Sanborn and B.D. Hammock. 2010. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure – activity relationships, pharmacokinetics, and reduction of inflammatory pain. J. Med. Chem. 53(19):7067-7075. PMCID: PMC3285450. [Download]
773. Morisseau, C., B. Inceoglu, K. Schmelzer, H-J. Tsai, S.L. Jinks, C.M. Hegedus and B.D. Hammock. 2010. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J Lipid Res. 51(12):3481-3490. PMCID: PMC2975720. [Download]
776. Huang, S-X., H-Y. Li, J-Y. Liu, C. Morisseau, B.D. Hammock and Y-Q. Long. 2010. Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved Pharmacokinetic Properties. J Med Chem. 53(23):8376-8386. PMCID: PMC3070159. [Download]
777. Zhang, D., D. Ai, H. Tanaka, B.D. Hammock and Y. Zhu. 2010. DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1 dependent mechanism. Biochim. Biophs. Acta 1799(9):659-667. [Download]