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Publications pertaining to cancer, cell debris, and eicosanoids

075.  Hammock, B.D., D.N. Loury, D.E. Moody, B. Ruebner, R. Baselt, K.M. Milam, P. Volberding, A. Ketterman and R. Talcott.  1984.  A methodology for the analysis of the preneoplastic antigen.  Carcinogenesis.  5(11):1467-1473. [Download]


138.  Silva, M.H., R.N. Wixtrom and B.D. Hammock.  1988.  Epoxide-metabolizing enzymes in mammary gland and liver from BALB/c mice and effects of inducers on enzyme activity.  Cancer Res.  48:1390-1397. [Download]

219.  Moody, D.E., D.N. Loury, B.D. Hammock, B.H. Ruebner, J.M. Cullen, J.H. Hillman, D.W. Hillman, M.S. Rao, W.T. London, H.-W.L. Hann, I. Millman and M.J. Griffin.  1992.  Serum epoxide hydrolase (preneoplastic antigen) in human and experimental liver injury.  Cancer Epidemiol. Biomarkers & Prevention.  1:395-403. [Download]

332.  Senter, P., H. Marquardt, B. Thomas, B. Hammock, I. Frank and H. Svensson.  1996.  The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs.  Cancer Res.  56:1471-1484.  [Download]

378.  Zheng, J., G.T. Wurz, T.B. Cadman, M.W. DeGregorio, A.D. Jones and B.D. Hammock.  1997.  Haloenol lactone: A new synergist of cancer chemotherapy in vitro.  Biochem. Biophys. Res. Commun.  241:13-17. [Download]

420.  Greene, J.F. and B.D. Hammock.  1999.  Toxicity of linoleic acid metabolites, in: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. (Honn, K.V., L.J. Marnett and S.K. Nigam, eds.), pp. 471-477.  Advances in Experimental Medicine and Biology, Vol. 469, Kluwer Academic/Plenum Publishers, New York, NY. [Download]

578.  Nithipatikom, K., M.P. Endsley, M.A. Isbell, C.E. Wheelock, B.D. Hammock and W.B. Campbell.  2005.  A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells.  Biochem. Biophys. Res. Commun.  332(4):1028-1033.  PMID: 15919052. PMCID:PMC 1450257. [Download]


653.  Endsley, M.P., N. Aggarwal, M.A. Isbell, C.E. Wheelock, B.D. Hammock, J.R. Flack, W.B. Campbell and K. Nithipatikom. 2007. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: location, hydrolysis and 12-lipoxygenase metabolism. Int J Cancer. 121:984-991. PMID: 17443494. PMCID: PMC2565646. [Download]

727. Liu J, Park S, Morisseau C, Hwang SH, Hammock BD, Weiss RH (2009). Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol. Cancer Ther. 8(8):2193–2203 [Download]

770. Norwood S, Liao J, Hammock BD, Yang G (2010). Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis. Am J Transl Res 2(4):447–457 [Download]

817. Inoue H, Hwang SH, Wecksler AT, Hammock BD, Weiss RH (2011). Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy. Cancer Biol. Ther. 12(9):827–836 [Download]

825. Panigrahy, D., M.L. Edin, C.R. Lee, S. Huang, D.R. Bielenberg, C.E. Butterfield, C.M. Barnés, A. Mammoto, T. Mammoto, A. Luria, O. Benny, D.M. Chaponis, A.C. Dudley, E.R. Greene, J.A. Vergilio, G. Pietramaggiori, S.S. Scherer-Pietramaggiori, S.M. Short, M. Seth, F.B. Lih, K.B. Tomer, J. Yang, R.A. Schwendener, B.D. Hammock, J.R. Falck, V.L. Manthati, D.E. Ingber, A. Kaipainen, P.A. D’Amore, M.W. Kieran and D.C. Zeldin. 2012. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest. 122(1):178-91.  PMCID: PMC3248288. [P42 ES04699, R01 ES002710, R01 ES013933]. [Download]

860. Zhang W, Yang AL, Liao J, Li H, Dong H, Chung YT, Bai H, Matkowskyj KA, Hammock BD, Yang G (2012). Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice. Dig. Dis. Sci. 57(10):2580–2591 [Download]

882. Wettersten HI, Hee Hwang S, Li C, Shiu EY, Wecksler AT, Hammock BD, Weiss RH (2013). A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol. Ther. 14(3):278–285 [Download]


896. Zhang, G.D., D. Panigrahy, L. Mahakian, J. Yang, J.Y. Liu, K.S.S. Lee, H.I. Wettersten, A. Ulu, X. Hu, S. Tam, S.H. Hwang, E. Ingham, R.H. Weiss, K.W. Ferrara and B.D. Hammock. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth and metastasis. Proc Natl Acad Sci USA. 110(16):6530-35. PMID: 23553837. PMCID: PMC3631682. [R01 ES002710, P42 ES004699, cCRETE]  [Download]


898. Medina P de, Paillasse MR, Segala G, Voisin M, Mhamdi L, Dalenc F, Lacroix-Triki M, Filleron T, Pont F, Saati TA, Morisseau C, Hammock BD, Silvente-Poirot S, Poirot M (2013). Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties. Nat Commun 4:1840 [Download]

903. Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD (2013). Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors. Bioorg. Med. Chem. Lett. 23(13):3732–3737 [Download]

906. Chen L, Fan C, Zhang Y, Bakri M, Dong H, Morisseau C, Maddipati KR, Luo P, Wang C, Hammock BD, Wang M (2012). Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins Other Lipid Mediat. 104-105:42–48 [Download]

913. Panigrahy D., B.T. Kalish, S. Huang, D.R. Bielenberg, H.D. Le, J. Yang, M.L. Edin, C.R. Lee, O. Benny, D.R. Mudge, C.E. Butterfield, A. Mammoto, T. Mammoto, B. Inceoglu, R.L. Jenkins, M. Simpson, T. Akino, F.B. Lih, K.B. Tomer, D.E. Ingber, B.D. Hammock, J.R. Falck, V.L. Manthati, A. Kaipainen, P.A. D’Amore, M. Puder, D.C. Zeldin and M.W. Kieran. 2013 Aug. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci USA. 110(33):13528-33. PMID: 12898174. PMCID: PMC3746918. [P42 ES004699, R01 ES002710, R01 ES0139633] [Download]

915. Zhang W, Liao J, Li H, Dong H, Bai H, Yang A, Hammock BD, Yang G (2013). Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency. Mol. Carcinog. 52(9):726–728 [Download]


930. Zhang, G.D., S. Kodani and B.D. Hammock. 2013 Dec. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog Lipid Res. 53C: 108-123. PMID: 24345640. PMCID: PMC3914417. [Download]

933. Zhang W, Li H, Dong H, Liao J, Norwood S, Hammock BD, Yang GY (2013). Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis. Anticancer Res. 33(12):5261–5271 [Download]

934. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD (2014). Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs 25(4):433–446 [Download]

950. Zhang, G., D. Panigrahy, S.H. Hwang, J. Yang, L.M. Mahakian, H. I. Wettersten, J.Y. Liu, Y. Wang, E.S. Ingham, S. Tam, M.W. Kieran, R.H. Weiss, K.W. Ferrara and B.D. Hammock. 2014 Jul. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci USA. 111(30):11127-32. PMID: 25024195. PMCID: PMC4121808. [R01 ES002710, P42 ES004699, U54 OH07550, R01 CA134659, R01 CA112356, R01 CA103828, R01 CA135401, R01 DK082690, cCRETE] [Download]


951. Gupta R, Dong Y, Solomon PD, Wettersten HI, Cheng CJ, Min J, Henson J, Dogra SK, Hwang SH, Hammock BD, Zhu LJ, Reddel RR, Saltzman WM, Weiss RH, Chang S, Green MR, Wajapeyee N (2014). Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc. Natl. Acad. Sci. U.S.A. 111(30):E3062-71 [Download]


969. Wang, W., J. Zhu, D. Lyu, D. Panigrahy, K.W. Ferrara and B.D. Hammock and G. Zhang. 2014 Oct.. ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat. 113-115C:13-20. PMID: 25019221. PMCID: PMC4306447. [R01 ES002710, P42 ES004699, R01 CA134659, R01 CA112356, R01 CA103828, cCRETE] [Download]

977. Wecksler, A.T., S.H. Hwang, J.Y. Liu, H.I. Wettersten, C. Morisseau, J. Wu, R.H. Weiss and B.D. Hammock. 2015 Jan. Biological Evaluation of a Novel Sorafenib Analogue, t-CUPM. Cancer Chemother Pharmacol. 75(1):161-71. PMID: 25413440. PMCID: PMC4400119. [Download]

1020. Chen, C.C., L. Xing, M. Stark, T. Ou, K. Xiao, S.G. Kamita, T. Li, Y.H. Hsu, N.S. Lin, B.D. Hammock, K. Lam and R.H. Cheng. 2016 Feb. Chemically activatable viral capsid functionalized for cancer targeting. Nanomedicine (Lond). 11(4):377-90. PMID: 26786134. PMCID: PMC4910953. [Download]


1033. Kim, J., A. Ulu, D. Wan, J. Yang, B.D. Hammock and R.H. Weiss. 2016 May. Addition of DHA synergistically enhances the efficacy of regorafenib for kidney cancer therapy. Mol Cancer Ther. 15(5):890-98.  [Download]

1070. Barnych, B., A.A. Rand, T. Cajka, K.S.S. Lee and B.D. Hammock. 2017. Synthesis of cyclooxygenase metabolites of 8,9-Epoxyeicosatrienoic acid (EET): 11- and 15-Hydroxy 8,9-EETs. Org Biomol Chem. 15:4308-4313. PMID: 28470279. [Download]

1095. Liao J, Hwang SH, Li H, Yang Y, Yang J, Wecksler AT, Liu J-Y, Hammock BD, Yang G-Y. Inhibition of mutant Kras(G12D)–initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM. Cancer letters. 2016;371(2):187-93. doi: 10.1016/j.canlet.2015.11.042. Epub 2015 Dec 9. PMID 26683769, PMCID:PMC4738175. [Download]

1098. Rand AA, Barnych B, Morisseau C, Cajka T, Lee KSS, Panigrahy D, Hammock BD. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(17):4370-5. Epub 2017/04/12. doi: 10.1073/pnas.1616893114. PubMed PMID: 28396419; PMCID: PMC5410821. [R01ES002710, P42ES04699]  [Download]

1109. Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan CX. 2018. COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin. Molecular cancer therapeutics. 17(2):474-483. 10.1158/1535-7163.Mct-16-0818.  PMCID: PMC5824635. [Download]

1155. Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP. 2019. Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. The Journal of Clinical Investigation. 129(7). doi: 10.1172/JCI127282. PMID: 28863368. PMCID: PMC5858941. [P42 ES004699, R01 ES002710] [Download]

1173. Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2019. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proc Natl Acad Sci U S A. 116(5):1698-703. doi: 10.1073/pnas.1803999116. PMID: 30647111. PMCID: PMC6358686. [P42 ES004699, R01 ES002710] [Download]

1175. Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih PB, Lee KSS, Minter LM, Kim D, Xiao H, Liu JY, Hammock BD, Zeldin DC, Zhang G. 2019. Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis. Cancer Res. 79(8):1822-30. doi: 10.1158/0008-5472.Can-18-3221. PMID: 30803995. PMCID: PMC6467714. [Download]


1210. Panigrahy D, Gilligan MM, Huang S, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD. 2020. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19? Cancer Metastasis Rev.1-4. 10.1007/s10555-020-09889-4.  PMCID: PMC7207990. [Download

1224. Hammock BD, Wang W, Gilligan MM, Panigrahy D. 2020. Eicosanoids: the Overlooked Storm in COVID-19? The American Journal of Pathology. PMID: 32650004; PMCID: PMC7340586.[Download

1233. Fishbein A, Wang W, Yang H, Yang J, Hallisey VM, Deng J, Verheul SML, Hwang SH, Gartung A, Wang Y, Bielenberg DR, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2020. Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. Proceedings of the National Academy of Sciences.202007412. PMID:32801214. PMCID: PMC7474612.[Download

1241. Fishbein A, Hammock BD, Serhan CN, Panigrahy D. 2020. Carcinogenesis: Failure of resolution of inflammation? Pharmacology & Therapeutics.107670. PMID: 32891711. PMCID: PMC7470770. [Download]

1250. Maolin Tu, Weicang Wang, Bruce D. Hammock, Guodong Zhang. 2020. ω-3 polyunsaturated fatty acids on colonic inflammation and colon cancer: roles of lipid metabolizing enzymes involved. Nutrients. 10.3390/nu12113301. PMID: 33126566. [Download]

1255. Xia R, Sun L, Liao J, Li H, You X, Xu D, Yang J, Hwang SH, Jones RD, Hammock B, Yang GY. 2019. Inhibition of Pancreatic Carcinoma Growth Through Enhancing ω-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase.Anticancer Res. 39(7):3651-3660. 10.21873/anticanres.13513. PMID: 31262891. PMCID: PMC7117872. [Download]

1275. Xie M, Yang J, Zhang J, Sherman HL, Zhang Z, Minter LM, Hammock BD, Park Y, Zhang G. 2020. Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in Il-10(-/-) Mice. J Agric Food Chem. 68(29):7641-7647. 10.1021/acs.jafc.0c03024. PMID: 32594738. PMCID: PMC7901524. [R35 ES030443, P42 ES04699]. [Download]

1280. Mo F, Duan S, Jiang X, Yang X, Hou X, Shi W, Carlos CJJ, Liu A, Yin S, Wang W, Yao H, Yu Z, Tang Z, Xie S, Ding Z, Zhao X, Hammock BD, Lu X. 2021. Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy. Signal Transduction and Targeted Therapy. 6(1):80. 10.1038/s41392-021-00462-1. PMID: 33627635. PMCID: PMC 7904846. [R35 ES030443, P42 ES04699]. [Download]

1290. Codony S, Calvó-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Pérez C, Rodríguez-Franco MI, Pizarro-Delgado J, Corpas R, Griñán-Ferré C, Pallàs M, Sanfeliu C, Vázquez-Carrera M, Hammock BD, Feixas F, Vázquez S. 2021. From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis. Journal of Medicinal Chemistry. 10.1021/acs.jmedchem.0c01601. PMID: 33945278. [R35 ES030443, P42 ES004699, R01 DK107767, R01 DK103616]. [Download]

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