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979. Shihadih, D.S., T.R. Harris, J. Yang, O. Merzlikin, K.S.S. Lee, B.D. Hammock and C. Morisseau. 2015 Jan. Identification of potent inhibitors of the chicken soluble epoxide hydrolase. Bioorg Med Chem Lett. 25(2):276-79. PMCID: 4277729. [Download]

980. Kim, J., S. Yoon, M.L. Toews, J.D. Imig, S.H. Hwang, B.D. Hammock and B.J. Padanilam. 2015 Jan. Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. Am J Physiol Renal Physiol. 308(2):F131-39.  [Download]

981. Lopez-Vicario, C., V. Garcia-Alonso, J. Alcaraz-Quiles, B. Rius, E. Titos, A. Lopategi, B.D. Hammock, V. Arroyo and J. Claria. 2015 Jan. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver. Role for omega-3 epoxides. Proc Natl Acad Sci USA. 112(2):536-41.  PMCID: PMC4299190. [Download]

983. Kitamura, S., C. Morisseau, B. Inceoglu, S.G. Kamita, G.R. De Nicola, M. Nyegue and B.D. Hammock. 2015 Feb. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana Baillon: Synthesis, quantification, and measurement of biological activities in vitro and in vivo. PLoS One. 10(2):e0117438.  [Download]

984. Xu, J., C. Morisseau, J. Yang, M. Mamatha and B.D. Hammock. 2015 Feb. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. Insect Biochem Mol Biol. 59C:41-49. [Download]

985. Li, S., H. Peng, R. Peng, Q. Fan, S. Zhao, D. Xua, C. Morisseau, N. Chiamvimonvat and B.D. Hammock. 2015 Apr. Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis. Atherosclerosis 239(2):557-565. [Download]

987. Nollmann, F.I., A.K. Heinrich, A.O. Brachmann, C. Morisseau, K. Mukherjee, A.M. Casanova-Torres, F. Strobl, D. Kleinhans, S. Kinski, K. Schultz, M. Beeton, M. Kaiser,Y.Y. Chu, L.P. Ke, A. Thanwisai, K.A.J. Bozhuyuk, N. Chantratita, F. Gotz, N.R. Waterfield, A. Vilcinskas, E.H.K. Stelzer, H. Goodrich-Blair, B.D. Hammock and H.B. Bode. 2015 Mar. A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem. 16(5):766-71. [Download]

988. Kodani, S.D. and B.D. Hammock. 2015 May. The 2014 Bernard B. Brodie Award Lecture Epoxide Hydrolases: Drug metabolism to therapeutics for chronic pain. Drug Metab Dispos. 43(5):788-802. [Download]

989. Sasso, O., K. Wagner, C. Morisseau, A.B. Inceoglu, B.D. Hammock and D. Piomelli. 2015 July. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol Res. 97:7-15. [Download]

991. Harris, T.R., A. Bettaieb, S. Kodani, H. Dong, R. Myers, N. Chiamvimonvat, F.G. Haj and B.D. Hammock. 2015 July. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 286(2):102-111. [Download]

992. Brunn, D.A., Z. Cao, A.B. Inceoglu, S.T. Vito, A.T. Austin, S. Hulsizera, B.D. Hammock, D.J. Tancredi, M.A. Rogawski, I.N. Pessah and P.J. Lein. 2015. Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 95:332-42. [Download]

993. Fahrmann, J., D. Grapov, J. Yang, B.D. Hammock, O. Fiehn, G.I. Bell and M. Hara. 2015. Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceridemia. Am J Physiol Endocrinol Metab. 308(11):E978-89. [Download]

994. Qin, J., D. Sun, H. Jiang, S. Kandhi, G. Froogh, S.H. Hwang, B.D. Hammock, M. Wolin, C. Thompson, T. Hintze and A. Huang. 2015 Jun. Inhibition of soluble epoxide hydrolase increases coronary perfusion in mice. Physiol Rep. 3:e12427. [Download]

996. Bettaieb, A., S. Chahed, S. Bachaalany, S. Griffey, B.D. Hammock and Fawaz G. Haj. 2015 Aug. Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol Pharmacol. 88(2):28-90.[Download]

997. Inceoglu, B., A. Bettaieb, C.A. Trindade da Silva, K.S.S. Lee, F.G. Haj and B.D. Hammock. 2015. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proc Natl Acad Sci USA. 112(29):9082-87. [Download]

998. Thomson, S., M.L. Edin, F.B. Lih, M. Davies, M.M. Yaqoob, B.D. Hammock, D. Gilroy, D.C. Zeldin and D. Bishop-Bailey. 2015 Aug. Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins. Biochem Biophys Res Commun. 463(4):774-80. [Download]

999. Bahl, C.D., K.L. Hvorecny, J.M. Bomberger, B.A. Stanton, B.D. Hammock, C. Morisseau and D.R.Madden. 2015 Aug. Inhibiting an epoxide hydrolase virulence factor from Pseudomonas aeruginosa protects CFTR. Angew Chem Int Ed Engl. 54(34):9881-85. [Download]

1001. Walkowska, A., M. Kuczeriszka, J. Sadowski, K.H. Olszynski, L. Dobrowolski, L. Cervenka, B.D. Hammock and E. Kompanowska-Jezierska. 2015. High salt intake increases blood pressure in normal rats: putative role of 20-HETE and no evidence on changes in renal vascular reactivity. Kidney Blood Press Res. 40(3):323-34. [Download]

1002. Cui, Y., D. Li, C. Morisseau, J. Dong, J. Yang, D. Wan, M. Rossotti, G. Gonzalez, S.J. Gee and B.D. Hammock. 2015 Sept. Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase. Anal Bioanal Chem. 407(24):7275-83. [Download]

1004. Lu, X., R. Elizondo, R. Nielsen, E. Christensen, J. Yang, B.D. Hammock and M.A. Watsky. 2015 Sept. Vitamin D in Tear Fluid. Invest Ophthalmol Vis Sci. 56(10):5880-87. [Download]

1006. Hwang, V.J., J. Kim, A. Rand, C Yang, B.D. Hammock, L.M. Guay-Woodford and R.H. Weiss. 2015 Sept. The cpk model of recessive PKD shows glutamine-dependence associated with the production of the oncometabolite 2-hydroxyglutarate. Am J Physiol Renal Physiol. 309(6):F492-98. [Download]

1008. Kim, I.H., Y.K. Park, H. Nishiwaki, B.D. Hammock and K. Nishi. 2015 Nov. Structure-activity relationships of amide-phosphonate derivatives as inhibitors of the human soluble epoxide hydrolase. Bioorg Med Chem. 23(22):7199-210. [Download]

1009. Liu, J.Y., H.J. Tsai, C. Morisseau, J. Lango, S.H. Hwang, T. Watanabe, I.H. Kim and B.D. Hammock. 2015 Dec. In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors. Biochem Pharmacol. 98(4):718-31. PMCID: PMC4656071. [Download]

1010. Burmistrov, V., C. Morisseau, D. Danilov, T.R. Harris, I. Dalinger, I. Vatsadze, T. Shkineva, G.M. Butov and B.D. Hammock. 2015 Dec. 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 25(23):5514-19. PMCID: PMC4654407. [Download]

1011. Nording, M.L., J. Yang, L. Hoang, V. Zamora, D. Uyeminami, I. Espiritu, K.E. Pinkerton, B.D. Hammock and A. Luria. 2015. Bioactive lipid profiling reveals drug target engagement of a soluble epoxide hydrolase inhibitor in a murine model of tobacco smoke exposure. J Metabolomics. 1:1. [Download]

1012. Deng, L., X. Li, D. Xu, C. Morisseau, N. Chiamvimonvat and B.D. Hammock. 2015. Correspondence. Aerobic exercise-based rehabilitation affects the activities of progenitor endothelial cells through EETs pathway. Med Hypotheses. 85(6):1037-38. [Download]

1014. Goswami, S.K., B. Inceoglu, J. Yang, D. Wan, S.D. Kodani, C.A.Trindade da Silva, C. Morisseau and B.D. Hammock. 2015 Dec. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE2 induced pain model. Toxicol Appl Pharmacol. 289(3): 419-27. PMCID: PMC4666679. [Download]

1015. Ostermann, A.I, J. Herbers, I. Willenberg, R. Chen, S.H. Hwang, R. Greite, C. Morisseau, F. Güler, B.D. Hammock and N.H. Schebb. 2015 Sep. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins Other Lipid Mediat. 121(Pt A):131-37. PMCID: PMC4688279. [Download]

1016. Berthelot, C.C., S.G. Kamita, R. Sacchi, J. Yang, M.L. Nording, K. Georgi, C.H. Karbowski, J.B. German, R.H. Weiss, R.J. Hogg, B.D. Hammock, and A.M. Zivkovic. 2015 Dec. Changes in PTGS1 and ALOX12 gene expression in peripheral blood mononuclear cells are associated with changes in arachidonic acid, oxylipins, and oxylipin/fatty acid ratios in response to omega-3 fatty acid supplementation. PLoS ONE. 10(12):e0144996. PMCID: PMC4681469. [Download]

1017. Cervenka, L., V. Melenovský, Z. Husková, A. Sporková, M. Bürgelová, P. Škaroupková, S.H. Hwang, B.D. Hammock, J.D. Imig and J. Sadowski. 2015 Dec. Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula. PhysiolRes. 64(6)857-73. [Download]

1018. Tong, X., A.R. Khandelwal, X. Wu, Z. Xu, W. Yu, C. Chen, W. Zhao, J. Yang, Z. Qin, R.M. Weisbrod, F. Seta, T. Ago, K.S.S. Lee, B.D. Hammock, J. Sadoshima, R.A. Cohen and C. Zeng. 2016 Jan. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 92:30-40.  [Download]

1019. Zhou, Y., G.Y. Sun, T. Liu, J.X. Duan, H.F. Zhou, K.S.S. Lee, B.D. Hammock, X. Fang, J.X. Jiang and C.X. Guan. 2016 Feb. Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice. Cell Tissue Res. 363(2):399-409.  PMCID: PMC4738109. [Download]

1021. Akintoye, E., J.H.Y. Wu, T. Hou, J. Yang, B.D. Hammock and D. Mozaffarian. 2016 Mar. Effect of Fish Oil on Monoepoxides Derived from Fatty Acids during Cardiac Surgery. J Lipid Res. 57(3):492-98. PMCID: PMC4766998. [Download]

1023. Shih, P.B., J. Yang, C. Morisseau, J.B. German, A. Scott-Van Zeeland, A.M. Armando, O. Quehenberger, A.W. Bergen, P. Magistretti, W. Berrettini, K.A. Halmi, N. Schork, B.D. Hammock and W. Kaye. 2016 Apr. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry. 21(4):537-46. PMCID: PMC4591075. [Download]

1025. Zhao, Y., D. Wan, J. Yang, B.D. Hammock and P. Ortiz de Montellano. 2016 May. Catalytic activities of tumor-specific human cytochrome P450 CYP2W1 towards endogenous substrates. Drug Metab Dispos. 44(5):771-80. [Download]

1026. Sun, C., S.I. Simon, G.A. Foster, C.E. Radecke, H.V. Hwang, X. Zhang, B.D. Hammock, N. Chiamvimonvat and A.A. Knowlton. 2016 Apr. 11,12-Epoxyecosatrienoic Acids Mitigate Endothelial Dysfunction Associated with Estrogen Loss and Aging: Role of Membrane Depolarization. J Mol Cell Cardiol. 94:180-88. [Download]

1027. Ren, Q., M. Ma, T. Ishima, C. Morisseau, J. Yang, J.Zhang, C. Yang, W. Yao, M. Han, B.D. Hammock and K. Hashimoto. 2016 Mar. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc Natl Acad Sci USA. 113(13):E1944-52. PMCID: PMC4822604. [Download]

1029. Butov GM, Burmistrov VV, Danilov DV, Pitushkin DA, Morisseau C, Hammock BD. 2015. Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase. Russ Chem Bull. 64(7):1569-75. doi: 10.1007/s11172-015-1043-y. [Download]

1030. Sharma, A., A.H. Khan, S.P. Levick, K.S.S. Lee, B.D. Hammock and J.D. Imig. 2016. Novel omega-3 fatty acid epoxygenase metabolite reduces kidney fibrosis. Int J Mol Sci. 17(5):751. [Download]

1031. Sirish, P., N. Li, V. Timofeyev, X.D. Zhang, L. Wang, J. Yang, K.S.S. Lee, A. Bettaieb, R.E. Myers, D. Su, V. Lau, D.K. Lieu, J.E. Lopez, J.N. Young, F. Haj, C. Ripplinger, B.D. Hammock and N. Chiamvimonvat. 2016 May. Molecular mechanisms and new treatment paradigm for atrial fibrillation. Circ Arrhythm Electrophysiol. 9(5):e003721. PMCID: PMC4869994. [Download]

1032. Goswami, S.K., D. Wan, J. Yang, C. Trindae da Silva, C. Morisseau, S.D. Kodani, G.Y. Yang, B. Inceoglu and B.D. Hammock. 2016 Jun. Anti-ulcer efficacy of soluble epoxide hydrolase inhibitor TPPU on diclofenac sodium induced intestinal ulcers. J Pharmacol Exp Ther. 357(3):529-36. [Download]

1033. Kim, J., A. Ulu, D. Wan, J. Yang, B.D. Hammock and R.H. Weiss. 2016 May. Addition of DHA synergistically enhances the efficacy of regorafenib for kidney cancer therapy. Mol Cancer Ther. 15(5):890-98. [Download]

1034. Kitamura, S., K.L. Hvorecny, J. Niu, B.D. Hammock, D.R. Madden and C. Morisseau. 2016 May. Rational design of potent and selective inhibitors of an epoxide hydrolase virulence factor from Pseudomonas aeruginosa. J Med Chem. 59(10):4790-99. [Download]

1035. Akhonkh, M.K., F.H. Yang, V. Samokhvalov, K.L. Jamieson, W.J. Cho, C. Wagg, R. Basu, Z. Kassiri, G.D. Lopaschuk, B.D. Hammock and J.M Seubert. 2016 Jun. Inhibition of soluble epoxide hydrolase limits mitochondrial damage and preserves function following ischemic injury. Front Pharmacol. 7:133. PMCID: PMC4896112. [Download]

1036. Lakkappa, N., P.T. Krishnamurthy, M.M.S. Bharath, D. Velmurugan, B.D. Hammock and S. Mulukutla. 2016 Aug. Possible role of epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders. Med Hypotheses. 93(2016):161-5. PMCID: PMC4985172. [Download]

1037. Ulu, A., B. Inceoglu, J. Yang, V. Singh, S. Vito, H. Wulff and B.D. Hammock. 2016 May. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. J Clin Toxicol. 6(3):10000300. [Download]

1038. Xu, J., B.D. Hammock, C. Morisseau, J. Yang, K.S.S. Lee and S.G. Kamita. 2016. Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Insect Biochem Mol Biol. 76:62-69.  NIHMS 803548. [Download]

1039.Li, D., X. Zhang, W. Pang, X. Sun, Y. Liu, L. Gan, B.D. Hammock, D. Ai and Y. Zhu. 2016 Sept. Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr-/- mice. J Mol Cell Cardiol. 98:128-137. [Download]

1040.McLellan, G.J., Aktas, Z., Hennes-Beean, E., Kolb, A.W., Larsen, I.V., Schmitz, E.J., Clausius, H., Yang, J., Hwang, S.H., Morisseau, C., Inceoglu, B., Hammock, B.D., and Brandt, C.R. 2016 Jan. Effect of a soluble epoxide hydrolase inhibitor, UC1728, on LPS-induced uveitis in the rabbit. J Ocul Biol. 4(1):7. [Download]

1041. Wu, X., J. Yang, C. Morisseau, B.D. Hammock, H.J. Lehmler. 2016 Aug. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci. 152(2):309-22. PMCID: PMC4960907. [Download]

1042. Gong, Y., Z. Fu, M.L. Edin, C.H. Liu, T.W. Fredrick, N.J. Saba, P.C. Morss, F.B. Lih, S.B. Burnim, S.S. Meng, K.S.S. Lee, J.P. SanGiovanni, A. Hellstrom, B.D. Hammock, D.C. Zeldin and L.E.H. Smith. 2016 Sept. Cytochrome P450 oxidase 2C inhibition augments the protective effects of ω-3 long-chain polyunsaturated fatty acid on pathological ocular angiogenesis. Arterioscler Thromb Vasc Biol. 36(9):1919-27. PMCID: PMC5010176. [Download]

1044. Ghosh, R., S. Goswami, L.F.B.B.Feitoza, B.D. Hammock and A.V. Gomes. 2016 Aug. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol. 223:923-35.  [Download]

1046. Mouchlis, V.D., C. Morisseau, B.D. Hammock, S. Li, J.A. McCammon and E. Dennis. 2016 Oct. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 24(20):4801-11. [Download]

1047. Khan, A.H., S.H. Hwang, A. Sharma. J.A. Corbett, B.D. Hammock and J.D. Imig. 2016 Sept. A dual COX-2/sEH inhibitor improves metabolic profile and reduces kidney injury in zucker diabetic fatty rat. Prostaglandins Other Lipid Mediat. 125:40-47. PMCID: PMC5035206. [Download]

1049. Liu, J.Y., C. Morisseau, H. Huang and B.D. Hammock. 2016 Oct. Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. J Ethnopharmacol. 194:475-82. PMID: 27702689. [Download]

1050. Lee, K.S.S., N. Henriksen, C.J. Ng, J. Yang, W. Jia, C. Morisseau, A. Andaya, M.K. Gilson and B.D. Hammock. 2016. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Arch Biochem Biophys. 613:1-11. [Download]

1051. Harris, T.R., S. Kodani, J. Yang, D.M. Imai and B.D. Hammock. 2016 Dec. An ω-3 enriched diet does not attenuate CCl4-induced hepatic fibrosis. J Nutr Biochem. 38:93-101. PMID: 27732914. PMCID: PMC5102762. [Download]

1052. Kodani, S.D., H.B. Overby, C. Morisseau, J. Chen, L. Zhao and B.D. Hammock. 2016 Nov. Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicol Lett. 262:92-99. PMID: 27659731. PMCID: PMC5096949. [Download]

1053. Flitter, B.A., K.L. Hvorecny, E. Ono, T. Eddens, J. Yang, D.H. Kwak, C.D. Bahl, T. Hampton, C. Morisseau, B.D. Hammock, X. Liu, J.S. Lee, J.K. Kolls, B.D. Levy, D.R. Madden and J.M. Bomberger. 2016. Pseudomonas aeruginosa sabotages the generation of host pro-resolving lipid mediators. Proc Natl Acad Sci USA. 2017 Jan 3;114(1):136-141. PMID: 27980032. [Download

1054. Zhang, Y., G. Hong, K.S.S. Lee, B.D. Hammock, D. Gebremedhin, D.R. Harder, R.C. Koehler and A. Sapirstein. 2017. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. J Neurochem. 140(5):814-825. PMID: 28002622. [Download]

1056. C.E. Richardson, M. Hennebelle, Y. Otoki, D. Zamora, J. Yang, B.D. Hammock and A.Y Taha. 2017. Lipidomic quantitation of oxidized fatty acids in plant and algae oils. J Agric Food Chem. 65(9):1941-1951. PMID: 28157307. [Download]

1057. Hennebelle, M., Y. Otoki, J. Yang, B.D. Hammock, A.J. Levitt, A.Y. Taha and W. Swardfager. 2017. Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: an exploratory study. Psychiatry Res. 252:94-101. PMID: 28259037. [Download]

1058. Trindade-da-Silva, C.A., A. Bettaieb, M.H. Napimoga, K.S.S. Lee, B. Inceoglu, C. Ueira-Vieira, D. Bruun, S. Goswami, F. Haj, and B.D. Hammock. 2017. Soluble epoxide hydrolase pharmacological inhibition decreases alveolar bone loss by modulating host inflammatory response, RANK-related signaling, ER stress and apoptosis. J Pharmacol Exp Ther. 361(3):408-416. PMID: 28356494. [Download]

1059. Wagner, K., J. Gilda, J. Yang, C. Morisseau, A. Gomez and B.D. Hammock. 2017. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behavioural Brain Research. 326:69-76. PMID: 28259677.  [Download]

1061. Islam, O., P. Patil, S.K. Goswami, R. Razdan, M.N. Inamdar, R. Mohammed, B. Inceoglu, K.S.S. Lee, S.H. Hwang and B.D. Hammock. 2017. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion induced cardiac damage in normal, hypertensive and diabetic rats. Cardiovasc Ther. 35(3). PMID: 28296232. [Download]

1062. M. Fiala, G. Kooij, K. Wagner, B.D. Hammock, M. Pellegrini and M. Pellegrini. 2017. Modulation of innate immunity of patients with Alzheimer’s disease by omega-3 fatty acids. FASEB. 2017 April 18. PMID: 28420693. [Download]

1064.  Wang, Z., Y. Fang, J. Teague, H. Wong, C. Morisseau, B.D. Hammock, D. Rock and Z. Wang. 2017. In vitro metabolism of oprozomib, an oral proteasome inhibitor: role of epoxide hydrolases and cytochrome P450s. Drug Metab Dispos. 45(7):712-720. PMID: 28428366. [Download]

1065. Zhou, Y., T. Liu, J.X. Duan, P. Li, G.Y. Sun, Y.P. Liu, Z. Fang, K.S.S. Lee, B.D. Hammock and C.X. Guan. 2017. Soluble epoxide hydrolase inhibitor attenuates lipopolysaccharide-induced acute lung injury and improves survival in mice. Shock. 47(5):638-645. PMID: 27753791. [Download]

1066. Li, D., Y. Cui, C. Morisseau, S.J. Gee, C.S. Bever, X. Liu, L. Tang, B.D. Hammock and Y. Ting. 2017. Nanobody based Immunoassay for Human Soluble Epoxide Hydrolase Detection using PolyHRP for Signal Enhancement—the Rediscovery of PolyHRP? Anal. Chem. 89(11):6248-6256. PMID: 28460522. [Download]

1068.   Bettaieb A, Koike S, Chahed S, Zhao Y, Bachaalany S, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG. 2017. Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. Febs j. 284(13):1970-86. doi: 10.1111/febs.14100. PMCID: PMC5515292. [Download]

1069. Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD. 2017. Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs. Org Biomol Chem. 15(20):4308-13. doi: 10.1039/c7ob00789b. PMCID: PMC5527127. [Download]

1070. Goswami, S.K., D. Wan, J. Yang, B. Inceoglu, M. Thomas, G.Y. Yang and B.D. Hammock. 2017. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion decreases diclofenac-induced gastric ulcers. Life Sci. 180:114-122. PMID: 28522175. [Download]

1071. G.J. Fischer, W. Bacon, J. Yang, J.M. Palmer, T. Dagenais, B.D. Hammock, N.P. Keller. 2017. Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus. Frontiers in Microbiology. 8:831 PMID: 28536571. [Download]

1072. G.M. Butov, V.V. Burmistrov, D.V. Danilov, A.D. Averin, C. Morisseau, S. Kodani, B.D. Hammock. 2016. Synthesis of epoxide hydrolase sEH inhibitors and study of its inhibitory properties. Russian Chemical Bulletin. 65(9):2299-2305. [Download]

1075. Ramsden, C.E., A. Ringel, S.F. Majchrzak-Hong, H. Blanchard, J. Yang, D. Zamora, J.D. Loewke, S.I. Rapoport, J.R. Hibbeln, J.M. Davis, B.D. Hammock and A.Y. Taha. 2016 Mar. Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes? Mol Pain. 12:1-14. PMID: 27030719. PMCID: PMC4955998 [Download]

1076.Wan, D., J. Yang, B. Barnych, S.H. Hwang, K.S.S. Lee, Y. Cui, J. Niu, M.A. Watsky and B.D. Hammock. 2017. A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine. J Lipid Res. 58(4): 798-808. PMID:28148721 PMCID:PMC5392736 [Download]

1077.Guedes, A., L. Galuppo, D. Hood. S.H. Hwang, C. Morisseau and B. D. Hammock. 2016. Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis. Equine Vet J. Epub ahead of print.49(3):345-351. PMID: 27338788 [Download

1078. A.Y. Taha, M. Hennebelle, J. Yang, M. Horowitz, D. Zumara, S.I. Rapoport, B.D. Hammock and C.E. Ramsden. 2016. Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid. Prostaglandins Leukot Essent Fatty Acids. Epub ahead of print. S0952-3278(16)30017-5. PMID: 27282298. PMCID: PMC5106341 [Download]

1079. Wagner, K.M., K.S.S. Lee, J. Yang and B.D. Hammock. 2016. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. Eur J Pain. Epub ahead of print Sep 2016. 21(3),456-465 PMID: 27634339 [Download]

1080. Yefidoff-Freedman, R., J. Fan, L. Yan, Q. Zhang, S. Rana, J. Contreras, K.L. Dias Teixeiraa, R.G.R.dos Santos, J. Halperin, B.D. Hammock, A. Natarajan, P. Wang, M. Chorev and B. Aktas. 2017. Development of 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylurea activators of the heme regulated inhibitor as selective activators of eIF2α Phosphorylation arm of the integrated endoplasmic reticulum stress response. J Med Chem 10.1021 PMID:28590739 [Download]

1081. Orcholski, M., A. Khurshudyan, K. Yuan, S.D. Kodani, C. Morisseau, L. Yancy Jr., A.J. Butte, E. Ashley, B.D. Hammock, L. Alexandrova, T.P. Alastalo, R.T. Zamanian and V. de Jesus Perez. 2017. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine induced pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 4:ajplung.00453. PMID:28473326 [Download]

1082. Flitter, B.A., K.L. Hvorecny, E. Ono, T. Eddens, J. Yang, D.H. Kwak, C.D. Bahl, T. Hampton, C. Morisseau, B.D. Hammock, X. Liu, J.S. Lee, J.K. Kolls, B.D. Levy, D.R. Madden and J.M. Bomberger. 2016. Pseudomonas aeruginosa sabotages the generation of host pro-resolving lipid mediators. Proc Natl Acad Sci USA. 3;114(1):136-14. PMID:27980032. PMCID:PMC5224368. [Download]

1083. Dong, L., Y. Zhou, Z.Q. Zhu, T. Liu, J.X. Duan, J. Zhang, P. Li, B.D. Hammock and C. Guan. 2016. Soluble epoxide hydrolase inhibitor suppresses the expression of triggering receptor expressed on myeloid cells-1 by inhibiting NF-κB activation in murine macrophage. Inflammation. Epub ahead of print. Oct 2016. 40(1):13-20 PMID:27696333 [Download]

1085. Wang, W. J. Yang, W. Qi, H. Yang, C. Wang, B. Tan, B.D. Hammock, Y. Park, D. Kim and G. Zhang. 2016. Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity (Silver Spring). Epub ahead of print. 2017 10.1002/oby.21692 PMID: 27891824. PMCID: PMC5182168 [Download]

1086. Kandhi, S., B. Zhang, G. Froogh, J. Qin, N. Alruwaili, Y. Le, Y.M. Yang, S.H. Hwang, B.D. Hammock, M.S. Wolin, A. Huang and D. Sun. 2016. EETs promote hypoxic pulmonary vasoconstriction via constrictor prostanoids. Am J Physiol Lung Cell Mol Physiol. 10.1152/ajplung.00038.2017. PMID: 28450284 [Download]

1087. Supp, D.M., J.M. Hahn, K.L. McFarland, K.A. Combs, K.S.S. Lee, B. Inceoglu, D. Wan, S.T. Boyce and B.D. Hammock. 2016. Soluble epoxide hydrolase inhibition and topical epoxyeicosatrienoic acid treatment improve vascularization of engineered skin substitutes after transplantation to mice. Plast Reconstr Surg Glob Open. 4(12):e1151 PMID:28293507 PMCID:PMC5222652 [Download]

1088. Wang, W., J. Yang, H. Yang, K. Sanidad, D. Kim, B.D. Hammock and G. Zhang. 2016. Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice: potential roles of leukotoxins in pathology of obesity. Prostaglandins Other Lipid Mediat 2016 Nov 28  10.1002/oby.21692  PMCID: PMC5182168 [Download]

1089. Kitamura, S., C. Morisseau, T.R. Harris, A.B. Inceoglu and B.D. Hammock. 2017. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales.May 4, 2017 PLoS One. 12(5): e0176571. PMCID: PMC5417501 [Download]

1090. Huang, F.F., Y. Liu, J. Chen, W.L. Yuan, J.F. Wang, B.D. Hammock, M.H. Wang and H. Huang. 2017. ShexiangBaoxin pills promote angiogenesis in myocardial infarction rats via up-regulating 20-HETE-mediated endothelial progenitor cells mobilization.2017.Jun7;263:184-191 PMID:28646793[Download]

1091. Bogdan Barnych, Natalia Vasylieva, Tom Joseph, Susan Julsizer, Hai Nguyen, Tomas Cajka, Isaac Pessah, Heike Wulff, Shirley Gee, Bruce Hammock.2017 Development of tetramethylenedisulfotetramine (TETS) hapten library: synthesis, electrophysiological studies and immune response in rabbits. Chemistry A European Journal. DOI: 10.1002/chem.201700783 [Download]

1093. Hvorecny, KL, Bahl CD, Kitamura S, Lee KSS, Hammock BD, Morisseau C, Madden DR. Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure. 2017;25(5):697-707.e4. doi: D-16-00443 PMID 28392259, PMCID:PMC5524515. [Download]

1094. Bahl CD, Hvorecny KL, Morisseau C, Gerber SA, Madden DR. Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry. 2016;55(5):788-97. PMCID: PMC4765904. [Download]

1095. Liao J, Hwang SH, Li H, Yang Y, Yang J, Wecksler AT, Liu J-Y, Hammock BD, Yang G-Y. Inhibition of mutant Kras(G12D)–initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM. Cancer letters. 2016;371(2):187-93. doi: 10.1016/j.canlet.2015.11.042. Epub 2015 Dec 9. PMID 26683769, PMCID:PMC4738175. [Download]

1096. Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Annals of the New York Academy of Sciences. 2016;1378(1):124-36. Epub 2016/07/29. doi: 10.1111/nyas.13137. PubMed PMID: 27467073; PMCID: PMC5063690. [Download]

1098. Rand AA, Barnych B, Morisseau C, Cajka T, Lee KSS, Panigrahy D, Hammock BD. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(17):4370-5. Epub 2017/04/12. doi: 10.1073/pnas.1616893114. PubMed PMID: 28396419; PMCID: PMC5410821. [Download]

1099. Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(36):E7545-e53. Epub 2017/08/23. doi: 10.1073/pnas.1620898114. PubMed PMID: 28827330; PMCID: PMC5594641. [Download]

1100. Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. Journal of veterinary pharmacology and therapeutics. 2017. Epub 2017/10/27. doi: 10.1111/jvp.12463. PubMed PMID: 29067696. [Download]

1101. Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. 2017. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat. 133:68-78. doi: 10.1016/j.prostaglandins.2017.08.003. PMCID: PMC5824649. [Download]

1102. Bettaieb A, Koike S, Hsu MF, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG. Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. Biochimica et biophysica acta. 2017;1861(11 Pt A):2758-65. Epub 2017/08/02. doi: 10.1016/j.bbagen.2017.07.021. PubMed PMID: 28757338. [Download]

1103. Deol P, Fahrmann J, Yang J, Evans JR, Rizo A, Grapov D, Salemi M, Wanichthanarak K, Fiehn O, Phinney B, Hammock BD, Sladek FM. Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. Scientific reports. 2017;7(1):12488. Epub 2017/10/04. doi: 10.1038/s41598-017-12624-9. PubMed PMID: 28970503; PMCID: PMC5624939. [Download]

1104. Sean D Kodani, Morgane Barthelemy, Shizuo G Kamita, Bruce D Hammock. Development of Amide-Based Fluorescent Probes for Selective Measurement of Carboxylesterase 1 Activity in Tissue Extracts. Analytical Biochemistry. Volume 539, 15 December 2017, Pages 81-89. PMID 29054529. [Download]

1105. Karen Wagner, Cindy B. Reynolds. William K. Schmidt, Bruce Hammock. Soluble Epoxide Hydrolase as a Therapeutic Target for Pain, Inflammatory and Neurodegenerative Diseases. Pharmacology and Therapeutics.  Volume 180, December 2017, Pages 62-76. PMID:28642117. [Download]

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