HAMMOCK LAB
The Laboratory of Pesticide Biotechnology
242. Winder, B.S., J. Nourooz-Zadeh, R.R. Isseroff, M.F. Moghaddam and B.D. Hammock. 1993. Properties of enzymes hydrating epoxides in human epidermis and liver. Int. J. Biochem. 25(9):1291-1301. [Download]
253. Cho, M., R. Jedrychowski, B. Hammock and A. Buckpitt. 1994. Reactive naphthalene metabolite binding to hemoglobin and albumin. Fundam. Appl. Toxicol. 22:26-33. [Download]
254. Dietze, E.C., E. Kuwano and B.D. Hammock. 1994. Spectrophotometric substrates for cytosolic epoxide hydrolase. Anal. Biochem. 216:176-187. [Download]
256. Hammock, B.D., F. Pinot, J.K. Beetham, D.F. Grant, M.E. Arand and F. Oesch. 1994. Isolation of a putative hydroxyacyl enzyme intermediate of an epoxide hydrolase. Biochem. Biophys. Res. Commun. 198(3):850-856. [Download]
259. Arand, M., D.F. Grant, J.K. Beetham, T. Friedberg, F. Oesch and B.D. Hammock. 1994. Sequence similarity of mammalian epoxide hydrolases to the bacterial haloalkane dehalogenase and other related proteins. FEBS Letters. 338(3):251-256. [Download]
264. Grant, D.F., J.L. Spearow, D.H. Storms, S. Edelhoff, D.A. Adler, C.M. Disteche, B.A. Taylor and B.D. Hammock. 1994. Chromosomal mapping and expression levels of a mouse soluble epoxide hydrolase gene. Pharmacogenetics. 4(2):64-72. [Download]
265. Grant, D.F., D.E. Moody, J. Beetham, D.H. Storms, M.F. Moghaddam, B. Borhan, F. Pinot, B. Winder and B.D. Hammock. 1994. The response of soluble epoxide hydrolase and other hydrolytic enzymes to peroxisome proliferators. In: Peroxisome Proliferators: Unique Inducers of Drug-Metabolizing Enzymes, (Moody, D.E., eds.), CRC Press, Inc., Boca Raton, Florida, pp. 97-112. [Download]
266. Stapleton, A., J.K. Beetham, F. Pinot, J.E. Garbarino, D.R. Rockhold, M. Friedman, B.D. Hammock and W.R. Belknap. 1994. Cloning and expression of soluble epoxide hydrolase from potato. Plant J. 6(2):251-258. [Download]
267. Kiyosue, T., J.K. Beetham, F. Pinot, B.D. Hammock, K. Yamaguchi-Shinozaki and K. Shinozaki. 1994. Characterization of an Aradibopsis cDNA for a soluble epoxide hydrolase gene that is inducible by auxin and water stress. Plant J. 6(2):259-269. [Download]
273. Gill, S.J., D.F. Grant, J.K. Beetham, C. Chang and B.D. Hammock. 1994. Peroxisomal proliferation and subcellular localization of soluble epoxide hydrolase: Role of peroxisomal targeting sequences. In: Peroxisome Proliferators: Unique Inducers of Drug-Metabolizing Enzymes, (Moody, D.E., eds.), CRC Press, Inc., Baca Raton, Florida, pp. 113-121. [Download]
276. Beetham, J.K., D. Grant, M. Arand, J. Garbarino, T. Kiyosue, F. Pinot, F. Oesch, W.R. Belknap, K. Shinozaki and B.D. Hammock. 1995. Gene evolution of epoxide hydrolases and recommended nomenclature. DNA Cell Biol. 14(1):61-71. [Download]
277. Borhan, B., S. Nazarian, E.M. Stocking, B.D. Hammock and M.J. Kurth. 1994. An efficient preparation of 18O-labeled epoxides. J. Org. Chem. 59:4316-4318. [Download]
281. Zeldin, D.C., S. Wei, J.R. Falck, B.D. Hammock, J.R. Snapper and J.H. Capdevila. 1995. Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: Substrate structural determinants of asymmetric catalysis. Arch. Biochem. Biophys. 316(1):443-451. [Download]
289. Pinot, F., D.F. Grant, J.K. Beetham, A.G. Parker, B. Borhan, S. Landt, A.D. Jones and B.D. Hammock. 1995. Molecular and biochemical evidence for the involvement of the Asp333-His523 pair in the catalytic mechanism of soluble epoxide hydrolase. J. Biol. Chem. 270(14):7968-7974. [Download]
298. Pinot, F., D.F. Grant, J.L. Spearow, A.G. Parker and B.D. Hammock. 1995. Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in liver and kidneys of mice. Biochem. Pharmacol. 50(4):501-508. [Download]
318. Borhan, B., T. Mebrahtu, S. Nazarian, M.J. Kurth and B.D. Hammock. 1995. Improved radiolabeled substrates for soluble epoxide hydrolase. Anal. Biochem. 231(1):188-200. [Download]
321. Borhan, B., A.D. Jones, F. Pinot, D.F. Grant, M.J. Kurth and B.D. Hammock. 1995. Mechanism of soluble epoxide hydrolase: Formation of an a-hydroxy ester-enzyme intermediate through Asp-333. J. Biol. Chem. 270(45):26923-26930. [Download]
326. Grant, D.F., J.F. Greene, F. Pinot, B. Borhan, M.F. Moghaddam, B.D. Hammock, B. McCutchen, H. Ohkawa, G. Luo and T.M. Guenthner. 1996. Development of anin situ toxicity assay system using recombinant baculoviruses. Biochem. Pharmacol. 51(4):503-515. [Download]
328. Parker, A.G., F. Pinot, D.F. Grant, J. Spearow and B.D. Hammock. 1996. Regulation of mouse liver microsomal esterases by clofibrate and sexual hormones. Biochem. Pharmacol. 51(5):677-685. [Download]
338. Zeldin, D.C., C.R. Moomaw, N. Jesse, K.B. Tomer, J. Beetham, B. Hammock and S. Wu. 1996. Biochemical characterization of the human liver cytochrome P450 Arachidonic acid epoxygenase pathway Arch. Biochem. Biophys. 330(1):87-96. [Download]
341. Zheng, J. and B.D. Hammock. 1996. Development of polyclonal antibodies for detection of protein modification by 1,2-naphthoquinone. Chem. Res. Toxicol. 9(5):904-909. [Download]
343. Zheng, J., A.E. Mitchell, A.D. Jones and B.D. Hammock. 1996. Haloenol lactone is a new isozyme-selective and active site-directed inactivator of glutathione S-transferase. J. Biol. Chem. 271(34):20421-20425. [Download]
344. Moghaddam, M.F., K. Motoba, B. Borhan, F. Pinot and B.D. Hammock. 1996. Novel metabolic pathways for linoleic acid and arachidonic acid metabolism. Biochim. Biophys. Acta. 1290(3):327-339. [Download]
360. Pinot, F., H. Bosch, J.-P. Salaun, F. Durst, C. Mioskowski and B.D. Hammock. 1997. Epoxide hydrolase activities in the microsomes and the soluble fraction fromVicia sativa seedlings. 35:103-110. [Download]
363. Moghaddam, M.F., D.F. Grant, J. Cheek, J.F. Greene K.C. Williamson and B.D. Hammock. 1997. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Nature Medicine 3(5):562-566. [Download]
368. Hammock, B.D., D.H. Storms, and D.F. Grant. 1997. Epoxide Hydrolases In: Comprehensive Toxicology, (Guengerich, F.P., ed.) Pergamon, Oxford. Vol. 3 Biotransformation, Chapter 18, pp.283-305, Pergamon, Oxford. [Download]
369. Zheng, J., C. Myung, A.D. Jones, and B.D. Hammock. 1997. Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine clara cells after exposure to naphthalene. Chem. Res. Toxicol. 10(9):1008-1014. [Download]
370. Müller, F., M. Arand, H. Frank, A. Seidel, W. Hinz, L. Winkler, K. Hänel, E. Blée, J.K. Beetham, B.D. Hammock and F. Oesch. 1997. Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates. Eur. J. Biochem. 245:490-496. [Download]
371. Hammock, B.D. 1997. Are leukotoxins toxic? Nature Medicine. 3(6):502. [Download]
377. Hammock BD, Casida KF. For the fun of science: A discussion with John E. Casida. Archives of insect biochemistry and physiology. 1998;37(1):1-7. doi: doi:10.1002/(SICI)1520-6327(1998)37:1<1::AID-ARCH1>3.0.CO;2-Z. [Download]
378. Zheng, J., G.T. Wurz, T.B. Cadman, M.W. DeGregorio, A.D. Jones, and B.D. Hammock. 1997. Haloenol lactone: A new synergist of cancer chemotherapy in vitro. Biochem. Biophys. Res. Commun. 241:13-17. [Download]
390. Mitchell, A.E., J. Zheng, B.D. Hammock, M. Lo Bello, and A.D. Jones. 1998. Structural and functional consequences of haloenol lactone inactivation of murine and human glutathione S-transferase. Biochemistry. 37(19):6752-6759 [Download]
391. Pinot, F., E.D. Caldas, C. Schmidt, D.G. Gilchrist, A.D. Jones, C.K. Winter and B.D. Hammock. 1997. Characterization of epoxide hydrolase activity in Alternaria alternata f. sp. lycopersici. Possible involvement in toxin production. Mycopathologia 140(1):51-58. [Download]
392. Debernard, S., C. Morisseau, T.F. Severson, L. Feng, H. Wojtasek, G.D. Prestwich and B.D. Hammock. 1998. Expression and characterization of the recombinant juvenile hormone epoxide hydrolase (JHEH) from Manduca sexta. Insect Biochem. Mol. Biol. 28(5-6):409-419. [Download]
394. Morisseau, C., G. Du, J.W. Newman and B.D. Hammock. 1998. Mechanism of mammalian soluble epoxide hydrolase inhibition by chalcone oxide derivatives. Arch. Biochem. Biophy. 356(2):214-228. [Download]
407. Mullen, R.T., R.N. Trelease, H. Duerk, M. Arand, B.D. Hammock, F. Oesch, and D.F. Grant. (1999) Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: Evidence for isozyme variants. FEBS Lett. 445(2-3):301-305. [Download]
410. Morisseau, C., B.L. Ward, D.G. Gilchrist and B.D. Hammock. 1999. Multiple epoxide hydrolases in Alternaria alternata f. sp. lycopersici and their relationship to medium composition and host-specific toxin production. Appl. Environ. Microbiol. 65(6):2388-2395. [Download]
411. Draper, A.J. and B.D. Hammock. 1999. Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver. Toxicol. Sci. 50(1):30-35. [Download]
412. Morisseau, C., M.H. Goodrow, D. Dowdy, J. Zheng, J.F. Greene, J.R. Sanborn, and B.D. Hammock. 1999. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc. Natl. Acad. Sci. USA 96(16):8849-8854. [Download]
415. Argiriadi, M.A., C. Morisseau, B.D. Hammock and D.W. Christianson. 1999. Detoxification of environmental mutagens and carcinogens: Structure, mechanism, and evolution of liver epoxide hydrolase. Proc. Natl. Acad. Sci. USA 96(19):10637-10642. [Download]
416. Draper, A.J. and B.D. Hammock. 1999. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicol. Sci. 52(1):26-32. [Download]
418. Morisseau, C., M. Derbel, T.R. Lane, D. Stoutamire and B.D. Hammock. 1999. Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicol. Sci. 52(2):148-153. [Download]
419. Lakritz, J., B.S. Winder, J. Noorouz-Zadeh, T.L. Huang, A.R. Buckpitt, B.D. Hammock, and C.G. Plopper. 2000. Hepatic and pulmonary enzyme activities in horses. Am. J. Vet. Res. 61(2):152-157. [Download]
420. Greene, J.F. and B.D. Hammock. 1999. Toxicity of linoleic acid metabolites, in:Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. (Honn, K.V., L.J. Marnett and S.K. Nigam, Eds.), pp. 471-477. Advances in Experimental Medicine and Biology, Vol. 469, Kluwer Academic/Plenum Publishers, New York, NY. [Download]
422. Greene, J.F., J. Zheng, D.F. Grant and B.D. Hammock. 2000. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicol. Sci. 53(2):352-360. [Download]
426. Draper, A.J. and B.D. Hammock. 2000. Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. Arch. Biochem. Biophys. 376(1):199-205. [Download]
427. Greene, J.F., J.W. Newman, K.C. Williamson and B.D. Hammock. 2000. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chem. Res. Toxicol. 13(4):217-226. [Download]
429. Greene, J.F., K.C. Williamson, J.W. Newman, C. Morisseau and B.D. Hammock. 2000. Metabolism of monoepoxides of methyl linoleate: Bioactivation and detoxification. Arch. Biochem. Biophys. 376(2):420-432. [Download]
430. Argiriadi, M.A., C. Morisseau, M.H. Goodrow, D.L. Dowdy, B.D. Hammock and D.W. Christianson. 2000. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. J. Biol. Chem. 275(20):15265-15270. [Download]
431. Morisseau, C., J.K. Beetham, F. Pinot, S. Debernard, J.W. Newman and B.D. Hammock. 2000. Cress and potato soluble epoxide hydrolases: Purification, biochemical characterization, and comparison to mammalian enzymes. Arch. Biochem. Biophys. 378(2):321-332. [Download]
433. Yamada, T., C. Morisseau, J.E. Maxwell, M.A. Argiriadi, D.W. Christianson and B.D. Hammock. 2000. Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. J. Biol. Chem. 275(30):23082-23088. [Download]
440. Fanucchi, M.V., A.R. Buckpitt, M.E. Murphy, D.H. Storms, B.D. Hammock and C.G. Plopper. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicol. Appl. Pharmacol. 168(3):253-267. [Download]
441. Nakagawa, Y., C.E. Wheelock, C. Morisseau, M.H. Goodrow, B.G. Hammock and B.D. Hammock. 2000. 3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues. Bioorganic Med. Chem. 8(11):2663-2673.[Download]
442. Yu, Z., F. Xu, L.M. Huse, C. Morisseau, A.J. Draper, J.W. Newman, C. Parker, L. Graham, M.M. Engler, B.D. Hammock, D.C. Zeldin and D.L. Kroetz. 2000. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ. Res. 87(11):992-998. [Download]
446. Newman, J.W., D.L. Denton, C. Morisseau, C.S. Koger, C.E. Wheelock, D.E. Hinton and B.D. Hammock. 2001. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environ Health Persp. 109(1):61-66. [Download]
448. Williamson, K.C., C. Morisseau, J.E. Maxwell and B.D. Hammock. 2000. Regio- and enantioselective hydrolysis of phenyloxiranes catalyzed by soluble epoxide hydrolase. Tetrahedron: Asymmetr. 11:4451-4462. [Download]
452. Slim, R., B.D. Hammock, M. Toborek, L.W. Robertson, J.W. Newman, C.H.P. Morisseau, B.A. Watkins,V. Saraswathi and B. Hennig. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol. Appl. Pharmacol. 171:184-193. [Download]
455. Morisseau, C., J.W. Newman, D.L. Dowdy, M.H. Goodrow and B.D. Hammock. 2001. Inhibition of microsomal epoxide hydrolases by ureas, amides and amines. Chem. Res. Toxicol. 14(4):409-415. [Download]
457. Fang, X., T.L. Kaduce, N.L. Weintraub, S. Harmon, L.M. Teesch, C. Morisseau, D.A. Thompson, B.D. Hammock and A.A. Spector. 2001. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells: Implications for the vascular effects of soluble epoxide hydrolase inhibition. J. Biol. Chem. 276(18):14867-14874. [Download]
458. Sisemore, M.F., J. Zheng, J.C. Yang, D.A. Thompson, C.G. Plopper, G.A. Cortopassi, and B.D. Hammock. 2001. Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction. Arch. Biochem. Biophys. 392(1):32-37. [Download]
459. Watkins, S.M., B.D. Hammock, J.W. Newman and J.B. German. 2001. Individual metabolism should guide agriculture toward foods for improved health and nutrition. Am. J. Clin. Nutr. 74:283-286. [Download]
460. Newman, J.W. and B.D. Hammock. 2001. Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. J. Chromatogr. A. 925:223-240. [Download]
469. Zheng, J., C.G. Plopper, J. Lakritz, D.H. Storms and B.D. Hammock. 2001. Leukotoxin-diol: A putative toxic mediator involved in acute respiratory distress syndrome. Am. J. Respir. Cell Mol. Biol. 25:434-438. [Download]
472. Watanabe, T. and B.D. Hammock. 2001. Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high performance liquid chromatography with electrospray tandem mass spectrometry. Anal. Biochem. 299:227-234. [Download]
476. Morisseau, C. and B.D. Hammock. 2002. Epoxide Hydrolases. In: Wiley Encyclopedia of Molecular Medicine, (Creighton, T.E. ed.), pp. 1194-1197, John Wiley & Sons, Inc., New York, NY. [Download]
478. Imig, J.D., X. Zhao, J.H. Capdevila, C. Morisseau and B.D. Hammock. 2002. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension 39(2):690-694. [Download]
480. Davis, B.B., D.A Thompson, L.L. Howard, C. Morisseau, B.D. Hammock and R.H. Weiss. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA. 99:2222-2227. [Download]
486. Nagy, S.R., J.R. Sanborn, B.D. Hammock and M.S. Denison. 2002. Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of Ah receptor agonists. Toxicol. Sci. 65:200-210. [Download]
487. Hennig, B., B.D. Hammock, R. Slim, M. Toborek, V. Saraswathi and L.W. Robertson. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int. J. Hyg. Environ. Health 205:95-102. [Download]
488. Morisseau, C., M.H. Goodrow, J.W. Newman, C.E. Wheelock, D.L. Dowdy and B.D. Hammock. 2002. Structural refinement of inhibitors of urea based soluble epoxide hydrolases. Biochem. Pharmacol. 63:1599-1608. [Download]
492. Newman, J.W., T. Watanabe and B.D. Hammock. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J. Lipid Res. 43:1563-1578. [Download]
495. Fornage, M., C.A. Hinojos, B.W. Nurowska, E. Boerwinkle, B.D. Hammock, C.H.P. Morisseau and P.A Doris. 2002. Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats. Hypertension 40:485-490. [Download]
500. Fang, X., N.L. Weintraub, C.L. Oltman, L.L. Stoll, T.L. Kaduce, S. Harmon, K.C. Dellsperger, C. Morisseau, B.D. Hammock and A.A. Spector. 2002. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. Amer. J. Physiol. Heart Circ. Physiol. 283:H2306-H2314. [Download]
504. Newman, J.W., C. Morisseau, T.R. Harris and B.D. Hammock. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. PNAS 100:1558-1563. [Download]
511. McElroy, N.R., P.C. Jurs, C. Morisseau and B.D. Hammock. 2003. QSAR and classification of murine and human soluble epoxide hydroalse inhibition by urea-like compounds. J. Med. Chem. 46:1066-1080. [Download]
517. Zhang, R., K-D. Kang, G. Shan and B.D. Hammock. 2003. Design, synthesis and evaluation of novel P450 fluorescent probes bearing ?-cyanoether. Tetrahedron Letts. 44:4331-4334. [Download]
522. Watanabe, T., C. Morisseau, J.W. Newman and B.D. Hammock. 2003. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metab. Dispos. 31:846-853. [Download]
523. Przybyla-Zawislak, B.D., P.K. Srivastava, J. Vázquez-Matiás, H.W. Mohrenweiser, J. Maxwell, B.D. Hammock, J.A. Bradbury, A. E. Enayetalla, D.C. Zeldin and D.F. Grant. 2003. Polymorphism in human soluble epoxide hydrolase. Mol. Pharmacol. 64:482-490. [Download]
524. Koivunen, M.E., C. Morisseau, J.W. Newman, W.R. Horwath and B.D. Hammock. 2003. Purification and characterization of a methylene urea-hydrolyzing enzyme from Rhizobium radiobacter (Agrobacterium tumefaciens). Soil Biol. Biochem. 35:1433-1442. [Download]
528. Taniai K., A.B. Inceoglu, K. Yukuhiro, B.D. Hammock. 2003. Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase inDrosophila melanogaster. Eur. J. Biochem. 270:4696-4705. [Download]
529 Viswanathan, S., B.D. Hammock, J.W. Newman, P. Meerarani, M. Toborek, and B. Hennig. 2003. Involvement of CYP 2C9 in Mediating the Proinflammatory Effects of Linoleic Acid in Vascular Endothelial Cells. J. Am. Coll. Nutr. 22(6):502-510 [Download]
533. Chiappe, C., E. Leandri, S. Lucchesi, D. Pieraccini, B.D. Hammock and C. Morisseau. 2004. Biocatalysis in ionic liquids: the stereoconvergent hydrolysis oftrans-ß-methylstyrene oxide catalyzed by soluble epoxide hydrolase. J. Molec. Catal. 27:243-248. [Download]
538. Yu, Z., B.B. Davis, C. Morisseau, B.D. Hammock, J.L. Olson, D.L. Kroetz and R.H. Weiss. 2004. Vascular localization of soluble epoxide hydrolase in the human kidney. Am. J. Physiol.-Renal Physiol. 286:F720-F726. [Download]
539. Koivunen, M.E., C. Morisseau, W.R. Horwath and B.D. Hammock. 2004. Isolation of a strain of Agrobacterium tumefaciens (Rhizobium radiobacter) utilizingmethylene urea (ureaformaldehyde) as nitrogen source. Can. J. Microbiol. 50:167-174. [Download]
540. DuTeaux, S.B., J.W. Newman, C.H. Morisseau, E.A. Fairbairn, K.A. Jelks, B.D. Hammock and M.G. Miller. 2004. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol. Sci. 78:187-195. [Download]
541. Gomez, G.A., C. Morisseau, B.D. Hammock and D.W. Christianson. 2004. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. Biochem. 43:4716-4723. [Download]
542. Zhao, X., T. Yamamoto, J.W. Newman, I.H. Kim, T. Watanabe, B.D. Hammock, J. Stewart, J.S. Pollock, D.M. Pollock and J.D. Imig. 2004. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. J. Am. Soc. Nephrol. 15:1244-1253. [Download]
543. Kim, I., C. Morisseau, T. Watanabe and B.D. Hammock. 2004. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J. Med. Chem. 47:2110-2122. [Download]
545. Stok, J.E., H. Huang, P.D. Jones, C.E. Wheelock, C. Morisseau and B.D. Hammock. 2004. Identification, expression and purification of a pyrethroid hydrolyzing carboxylesterase from mouse liver microsomes. J. Biol. Chem. 279:29863-29869. [Download]
548. Seubert, J., B. Yang, J.A. Bradbury, J. Graves, L. M. Degraff, S. Gabel, R. Gooch, J. Foley, J. Newman, L. Mao, H.A. Rockman, B.D. Hammock, E. Murphy and D.C. Zeldin. 2004. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/44 MAPK pathway. Circ. Res. 95:506-514. [Download]
551. Dey, A., R.S. Williams, D.M. Pollock, D.W. Stepp, J.W. Newman, B.D. Hammock and J.D. Imig. 2004. Altered Kidney CYP2C and Cylooxygenase-2 levels are associated with obesity-related albuminuria. Obes. Res. 12:1278-1289. [Download]
552. Dettmer, K. and B.D. Hammock. 2004. Metabolomics—A new field within the “omics” sciences. Environ. Health Perspect. 112:A396-A397. [Download]
554. Dettmer, K. and B.D. Hammock. 2004. Metabolomics-Just another "omics" word? G.I.T. Lab J. 8:29-30. [Download]
555. Fang, X., N.L. Weintraub, R.B. McCaw, S. Hu, S.D. Harmon, J.B. Rice, B.D. Hammock and A.A. Spector. 2004. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. Am. J. Physiol.-Heart C. 287:H2412-H2420. [Download]
557. Newman, J.W., C. Morisseau and B.D. Hammock. 2005. Epoxide hydrolases: Their roles and interactions with lipid metabolism. Prog. Lipid Res. 44:1-51. [Download]
558. Smith, K.R., K.E. Pinkerton, T. Watanabe, T.L. Pedersen, S.J. Ma and B.D. Hammock. 2005. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc. Natl. Acad. Sci. USA. 102:2186-2191. [Download]
560. Morisseau, C. and B.D. Hammock. 2005. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annu. Rev. Pharmacol. Toxicol. 45:311-333. [Download]
562. Hennebold, J.D., K. Mah, W. Perez, J.E. Vance, R.L. Stouffer, C. Morisseau, B.D. Hammock and E.Y. Adashi. 2005. Identification and characterization of an ovary-selective isoform of epoxide hydrolase. Biol. Reprod. 72:968-975. [Download]
563. Huang, H., J.E. Stok, D.W. Stoutamire, S.J. Gee and B.D. Hammock. 2005. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chem. Res. Toxicol. 18:516-527. [Download]
564. Jung, O., R.P. Brandes, I. Kim, F. Schweda, R. Schmidt, B.D. Hammock, R. Busse and I. Fleming. 2005. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension. 45:759-765. [Download]