HAMMOCK LAB
The Laboratory of Pesticide Biotechnology
326. Grant, D.F., J.F. Greene, F. Pinot, B. Borhan, M.F. Moghaddam, B.D. Hammock, B. McCutchen, H. Ohkawa, G. Luo and T.M. Guenthner. 1996. Development of anin situ toxicity assay system using recombinant baculoviruses. Biochem. Pharmacol. 51(4):503-515. [Download]
328. Parker, A.G., F. Pinot, D.F. Grant, J. Spearow and B.D. Hammock. 1996. Regulation of mouse liver microsomal esterases by clofibrate and sexual hormones. Biochem. Pharmacol. 51(5):677-685. [Download]
338. Zeldin, D.C., C.R. Moomaw, N. Jesse, K.B. Tomer, J. Beetham, B. Hammock and S. Wu. 1996. Biochemical characterization of the human liver cytochrome P450 Arachidonic acid epoxygenase pathway Arch. Biochem. Biophys. 330(1):87-96. [Download]
341. Zheng, J. and B.D. Hammock. 1996. Development of polyclonal antibodies for detection of protein modification by 1,2-naphthoquinone. Chem. Res. Toxicol. 9(5):904-909. [Download]
343. Zheng, J., A.E. Mitchell, A.D. Jones and B.D. Hammock. 1996. Haloenol lactone is a new isozyme-selective and active site-directed inactivator of glutathione S-transferase. J. Biol. Chem. 271(34):20421-20425. [Download]
344. Moghaddam, M.F., K. Motoba, B. Borhan, F. Pinot and B.D. Hammock. 1996. Novel metabolic pathways for linoleic acid and arachidonic acid metabolism. Biochim. Biophys. Acta. 1290(3):327-339. [Download]
360. Pinot, F., H. Bosch, J.-P. Salaun, F. Durst, C. Mioskowski and B.D. Hammock. 1997. Epoxide hydrolase activities in the microsomes and the soluble fraction fromVicia sativa seedlings. 35:103-110. [Download]
363. Moghaddam, M.F., D.F. Grant, J. Cheek, J.F. Greene K.C. Williamson and B.D. Hammock. 1997. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Nature Medicine 3(5):562-566. [Download]
368. Hammock, B.D., D.H. Storms, and D.F. Grant. 1997. Epoxide Hydrolases In: Comprehensive Toxicology, (Guengerich, F.P., ed.) Pergamon, Oxford. Vol. 3 Biotransformation, Chapter 18, pp.283-305, Pergamon, Oxford. [Download]
369. Zheng, J., C. Myung, A.D. Jones, and B.D. Hammock. 1997. Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine clara cells after exposure to naphthalene. Chem. Res. Toxicol. 10(9):1008-1014. [Download]
370. Müller, F., M. Arand, H. Frank, A. Seidel, W. Hinz, L. Winkler, K. Hänel, E. Blée, J.K. Beetham, B.D. Hammock and F. Oesch. 1997. Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates. Eur. J. Biochem. 245:490-496. [Download]
371. Hammock, B.D. 1997. Are leukotoxins toxic? Nature Medicine. 3(6):502. [Download]
377. Hammock BD, Casida KF. For the fun of science: A discussion with John E. Casida. Archives of insect biochemistry and physiology. 1998;37(1):1-7. doi: doi:10.1002/(SICI)1520-6327(1998)37:1<1::AID-ARCH1>3.0.CO;2-Z. [Download]
378. Zheng, J., G.T. Wurz, T.B. Cadman, M.W. DeGregorio, A.D. Jones, and B.D. Hammock. 1997. Haloenol lactone: A new synergist of cancer chemotherapy in vitro. Biochem. Biophys. Res. Commun. 241:13-17. [Download]
390. Mitchell, A.E., J. Zheng, B.D. Hammock, M. Lo Bello, and A.D. Jones. 1998. Structural and functional consequences of haloenol lactone inactivation of murine and human glutathione S-transferase. Biochemistry. 37(19):6752-6759 [Download]
391. Pinot, F., E.D. Caldas, C. Schmidt, D.G. Gilchrist, A.D. Jones, C.K. Winter and B.D. Hammock. 1997. Characterization of epoxide hydrolase activity in Alternaria alternata f. sp. lycopersici. Possible involvement in toxin production. Mycopathologia 140(1):51-58. [Download]
392. Debernard, S., C. Morisseau, T.F. Severson, L. Feng, H. Wojtasek, G.D. Prestwich and B.D. Hammock. 1998. Expression and characterization of the recombinant juvenile hormone epoxide hydrolase (JHEH) from Manduca sexta. Insect Biochem. Mol. Biol. 28(5-6):409-419. [Download]
394. Morisseau, C., G. Du, J.W. Newman and B.D. Hammock. 1998. Mechanism of mammalian soluble epoxide hydrolase inhibition by chalcone oxide derivatives. Arch. Biochem. Biophy. 356(2):214-228. [Download]
407. Mullen, R.T., R.N. Trelease, H. Duerk, M. Arand, B.D. Hammock, F. Oesch, and D.F. Grant. (1999) Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: Evidence for isozyme variants. FEBS Lett. 445(2-3):301-305. [Download]
410. Morisseau, C., B.L. Ward, D.G. Gilchrist and B.D. Hammock. 1999. Multiple epoxide hydrolases in Alternaria alternata f. sp. lycopersici and their relationship to medium composition and host-specific toxin production. Appl. Environ. Microbiol. 65(6):2388-2395. [Download]
411. Draper, A.J. and B.D. Hammock. 1999. Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver. Toxicol. Sci. 50(1):30-35. [Download]
412. Morisseau, C., M.H. Goodrow, D. Dowdy, J. Zheng, J.F. Greene, J.R. Sanborn, and B.D. Hammock. 1999. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc. Natl. Acad. Sci. USA 96(16):8849-8854. [Download]
415. Argiriadi, M.A., C. Morisseau, B.D. Hammock and D.W. Christianson. 1999. Detoxification of environmental mutagens and carcinogens: Structure, mechanism, and evolution of liver epoxide hydrolase. Proc. Natl. Acad. Sci. USA 96(19):10637-10642. [Download]
416. Draper, A.J. and B.D. Hammock. 1999. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicol. Sci. 52(1):26-32. [Download]
418. Morisseau, C., M. Derbel, T.R. Lane, D. Stoutamire and B.D. Hammock. 1999. Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicol. Sci. 52(2):148-153. [Download]
419. Lakritz, J., B.S. Winder, J. Noorouz-Zadeh, T.L. Huang, A.R. Buckpitt, B.D. Hammock, and C.G. Plopper. 2000. Hepatic and pulmonary enzyme activities in horses. Am. J. Vet. Res. 61(2):152-157. [Download]
420. Greene, J.F. and B.D. Hammock. 1999. Toxicity of linoleic acid metabolites, in:Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. (Honn, K.V., L.J. Marnett and S.K. Nigam, Eds.), pp. 471-477. Advances in Experimental Medicine and Biology, Vol. 469, Kluwer Academic/Plenum Publishers, New York, NY. [Download]
422. Greene, J.F., J. Zheng, D.F. Grant and B.D. Hammock. 2000. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicol. Sci. 53(2):352-360. [Download]
426. Draper, A.J. and B.D. Hammock. 2000. Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. Arch. Biochem. Biophys. 376(1):199-205. [Download]
427. Greene, J.F., J.W. Newman, K.C. Williamson and B.D. Hammock. 2000. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chem. Res. Toxicol. 13(4):217-226. [Download]
429. Greene, J.F., K.C. Williamson, J.W. Newman, C. Morisseau and B.D. Hammock. 2000. Metabolism of monoepoxides of methyl linoleate: Bioactivation and detoxification. Arch. Biochem. Biophys. 376(2):420-432. [Download]
430. Argiriadi, M.A., C. Morisseau, M.H. Goodrow, D.L. Dowdy, B.D. Hammock and D.W. Christianson. 2000. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. J. Biol. Chem. 275(20):15265-15270. [Download]
431. Morisseau, C., J.K. Beetham, F. Pinot, S. Debernard, J.W. Newman and B.D. Hammock. 2000. Cress and potato soluble epoxide hydrolases: Purification, biochemical characterization, and comparison to mammalian enzymes. Arch. Biochem. Biophys. 378(2):321-332. [Download]
433. Yamada, T., C. Morisseau, J.E. Maxwell, M.A. Argiriadi, D.W. Christianson and B.D. Hammock. 2000. Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. J. Biol. Chem. 275(30):23082-23088. [Download]
440. Fanucchi, M.V., A.R. Buckpitt, M.E. Murphy, D.H. Storms, B.D. Hammock and C.G. Plopper. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicol. Appl. Pharmacol. 168(3):253-267. [Download]
441. Nakagawa, Y., C.E. Wheelock, C. Morisseau, M.H. Goodrow, B.G. Hammock and B.D. Hammock. 2000. 3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues. Bioorganic Med. Chem. 8(11):2663-2673.[Download]
442. Yu, Z., F. Xu, L.M. Huse, C. Morisseau, A.J. Draper, J.W. Newman, C. Parker, L. Graham, M.M. Engler, B.D. Hammock, D.C. Zeldin and D.L. Kroetz. 2000. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ. Res. 87(11):992-998. [Download]