HAMMOCK LAB
The Laboratory of Pesticide Biotechnology
446. Newman, J.W., D.L. Denton, C. Morisseau, C.S. Koger, C.E. Wheelock, D.E. Hinton and B.D. Hammock. 2001. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environ Health Persp. 109(1):61-66. [Download]
448. Williamson, K.C., C. Morisseau, J.E. Maxwell and B.D. Hammock. 2000. Regio- and enantioselective hydrolysis of phenyloxiranes catalyzed by soluble epoxide hydrolase. Tetrahedron: Asymmetr. 11:4451-4462. [Download]
452. Slim, R., B.D. Hammock, M. Toborek, L.W. Robertson, J.W. Newman, C.H.P. Morisseau, B.A. Watkins,V. Saraswathi and B. Hennig. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol. Appl. Pharmacol. 171:184-193. [Download]
455. Morisseau, C., J.W. Newman, D.L. Dowdy, M.H. Goodrow and B.D. Hammock. 2001. Inhibition of microsomal epoxide hydrolases by ureas, amides and amines. Chem. Res. Toxicol. 14(4):409-415. [Download]
457. Fang, X., T.L. Kaduce, N.L. Weintraub, S. Harmon, L.M. Teesch, C. Morisseau, D.A. Thompson, B.D. Hammock and A.A. Spector. 2001. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells: Implications for the vascular effects of soluble epoxide hydrolase inhibition. J. Biol. Chem. 276(18):14867-14874. [Download]
458. Sisemore, M.F., J. Zheng, J.C. Yang, D.A. Thompson, C.G. Plopper, G.A. Cortopassi, and B.D. Hammock. 2001. Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction. Arch. Biochem. Biophys. 392(1):32-37. [Download]
459. Watkins, S.M., B.D. Hammock, J.W. Newman and J.B. German. 2001. Individual metabolism should guide agriculture toward foods for improved health and nutrition. Am. J. Clin. Nutr. 74:283-286. [Download]
460. Newman, J.W. and B.D. Hammock. 2001. Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. J. Chromatogr. A. 925:223-240. [Download]
469. Zheng, J., C.G. Plopper, J. Lakritz, D.H. Storms and B.D. Hammock. 2001. Leukotoxin-diol: A putative toxic mediator involved in acute respiratory distress syndrome. Am. J. Respir. Cell Mol. Biol. 25:434-438. [Download]
472. Watanabe, T. and B.D. Hammock. 2001. Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high performance liquid chromatography with electrospray tandem mass spectrometry. Anal. Biochem. 299:227-234. [Download]
476. Morisseau, C. and B.D. Hammock. 2002. Epoxide Hydrolases. In: Wiley Encyclopedia of Molecular Medicine, (Creighton, T.E. ed.), pp. 1194-1197, John Wiley & Sons, Inc., New York, NY. [Download]
478. Imig, J.D., X. Zhao, J.H. Capdevila, C. Morisseau and B.D. Hammock. 2002. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension 39(2):690-694. [Download]
480. Davis, B.B., D.A Thompson, L.L. Howard, C. Morisseau, B.D. Hammock and R.H. Weiss. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA. 99:2222-2227. [Download]
486. Nagy, S.R., J.R. Sanborn, B.D. Hammock and M.S. Denison. 2002. Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of Ah receptor agonists. Toxicol. Sci. 65:200-210. [Download]
487. Hennig, B., B.D. Hammock, R. Slim, M. Toborek, V. Saraswathi and L.W. Robertson. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int. J. Hyg. Environ. Health 205:95-102. [Download]
488. Morisseau, C., M.H. Goodrow, J.W. Newman, C.E. Wheelock, D.L. Dowdy and B.D. Hammock. 2002. Structural refinement of inhibitors of urea based soluble epoxide hydrolases. Biochem. Pharmacol. 63:1599-1608. [Download]
492. Newman, J.W., T. Watanabe and B.D. Hammock. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J. Lipid Res. 43:1563-1578. [Download]
495. Fornage, M., C.A. Hinojos, B.W. Nurowska, E. Boerwinkle, B.D. Hammock, C.H.P. Morisseau and P.A Doris. 2002. Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats. Hypertension 40:485-490. [Download]
500. Fang, X., N.L. Weintraub, C.L. Oltman, L.L. Stoll, T.L. Kaduce, S. Harmon, K.C. Dellsperger, C. Morisseau, B.D. Hammock and A.A. Spector. 2002. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. Amer. J. Physiol. Heart Circ. Physiol. 283:H2306-H2314. [Download]
504. Newman, J.W., C. Morisseau, T.R. Harris and B.D. Hammock. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. PNAS 100:1558-1563. [Download]
511. McElroy, N.R., P.C. Jurs, C. Morisseau and B.D. Hammock. 2003. QSAR and classification of murine and human soluble epoxide hydroalse inhibition by urea-like compounds. J. Med. Chem. 46:1066-1080. [Download]
517. Zhang, R., K-D. Kang, G. Shan and B.D. Hammock. 2003. Design, synthesis and evaluation of novel P450 fluorescent probes bearing ?-cyanoether. Tetrahedron Letts. 44:4331-4334. [Download]
522. Watanabe, T., C. Morisseau, J.W. Newman and B.D. Hammock. 2003. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metab. Dispos. 31:846-853. [Download]
523. Przybyla-Zawislak, B.D., P.K. Srivastava, J. Vázquez-Matiás, H.W. Mohrenweiser, J. Maxwell, B.D. Hammock, J.A. Bradbury, A. E. Enayetalla, D.C. Zeldin and D.F. Grant. 2003. Polymorphism in human soluble epoxide hydrolase. Mol. Pharmacol. 64:482-490. [Download]
524. Koivunen, M.E., C. Morisseau, J.W. Newman, W.R. Horwath and B.D. Hammock. 2003. Purification and characterization of a methylene urea-hydrolyzing enzyme from Rhizobium radiobacter (Agrobacterium tumefaciens). Soil Biol. Biochem. 35:1433-1442. [Download]
528. Taniai K., A.B. Inceoglu, K. Yukuhiro, B.D. Hammock. 2003. Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase inDrosophila melanogaster. Eur. J. Biochem. 270:4696-4705. [Download]
529 Viswanathan, S., B.D. Hammock, J.W. Newman, P. Meerarani, M. Toborek, and B. Hennig. 2003. Involvement of CYP 2C9 in Mediating the Proinflammatory Effects of Linoleic Acid in Vascular Endothelial Cells. J. Am. Coll. Nutr. 22(6):502-510 [Download]
533. Chiappe, C., E. Leandri, S. Lucchesi, D. Pieraccini, B.D. Hammock and C. Morisseau. 2004. Biocatalysis in ionic liquids: the stereoconvergent hydrolysis oftrans-ß-methylstyrene oxide catalyzed by soluble epoxide hydrolase. J. Molec. Catal. 27:243-248. [Download]
538. Yu, Z., B.B. Davis, C. Morisseau, B.D. Hammock, J.L. Olson, D.L. Kroetz and R.H. Weiss. 2004. Vascular localization of soluble epoxide hydrolase in the human kidney. Am. J. Physiol.-Renal Physiol. 286:F720-F726. [Download]
539. Koivunen, M.E., C. Morisseau, W.R. Horwath and B.D. Hammock. 2004. Isolation of a strain of Agrobacterium tumefaciens (Rhizobium radiobacter) utilizingmethylene urea (ureaformaldehyde) as nitrogen source. Can. J. Microbiol. 50:167-174. [Download]
540. DuTeaux, S.B., J.W. Newman, C.H. Morisseau, E.A. Fairbairn, K.A. Jelks, B.D. Hammock and M.G. Miller. 2004. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol. Sci. 78:187-195. [Download]
541. Gomez, G.A., C. Morisseau, B.D. Hammock and D.W. Christianson. 2004. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. Biochem. 43:4716-4723. [Download]
542. Zhao, X., T. Yamamoto, J.W. Newman, I.H. Kim, T. Watanabe, B.D. Hammock, J. Stewart, J.S. Pollock, D.M. Pollock and J.D. Imig. 2004. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. J. Am. Soc. Nephrol. 15:1244-1253. [Download]
543. Kim, I., C. Morisseau, T. Watanabe and B.D. Hammock. 2004. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J. Med. Chem. 47:2110-2122. [Download]
545. Stok, J.E., H. Huang, P.D. Jones, C.E. Wheelock, C. Morisseau and B.D. Hammock. 2004. Identification, expression and purification of a pyrethroid hydrolyzing carboxylesterase from mouse liver microsomes. J. Biol. Chem. 279:29863-29869. [Download]
548. Seubert, J., B. Yang, J.A. Bradbury, J. Graves, L. M. Degraff, S. Gabel, R. Gooch, J. Foley, J. Newman, L. Mao, H.A. Rockman, B.D. Hammock, E. Murphy and D.C. Zeldin. 2004. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/44 MAPK pathway. Circ. Res. 95:506-514. [Download]
551. Dey, A., R.S. Williams, D.M. Pollock, D.W. Stepp, J.W. Newman, B.D. Hammock and J.D. Imig. 2004. Altered Kidney CYP2C and Cylooxygenase-2 levels are associated with obesity-related albuminuria. Obes. Res. 12:1278-1289. [Download]
552. Dettmer, K. and B.D. Hammock. 2004. Metabolomics—A new field within the “omics” sciences. Environ. Health Perspect. 112:A396-A397. [Download]
554. Dettmer, K. and B.D. Hammock. 2004. Metabolomics-Just another "omics" word? G.I.T. Lab J. 8:29-30. [Download]
555. Fang, X., N.L. Weintraub, R.B. McCaw, S. Hu, S.D. Harmon, J.B. Rice, B.D. Hammock and A.A. Spector. 2004. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. Am. J. Physiol.-Heart C. 287:H2412-H2420. [Download]
557. Newman, J.W., C. Morisseau and B.D. Hammock. 2005. Epoxide hydrolases: Their roles and interactions with lipid metabolism. Prog. Lipid Res. 44:1-51. [Download]
558. Smith, K.R., K.E. Pinkerton, T. Watanabe, T.L. Pedersen, S.J. Ma and B.D. Hammock. 2005. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc. Natl. Acad. Sci. USA. 102:2186-2191. [Download]
560. Morisseau, C. and B.D. Hammock. 2005. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annu. Rev. Pharmacol. Toxicol. 45:311-333. [Download]
562. Hennebold, J.D., K. Mah, W. Perez, J.E. Vance, R.L. Stouffer, C. Morisseau, B.D. Hammock and E.Y. Adashi. 2005. Identification and characterization of an ovary-selective isoform of epoxide hydrolase. Biol. Reprod. 72:968-975. [Download]
563. Huang, H., J.E. Stok, D.W. Stoutamire, S.J. Gee and B.D. Hammock. 2005. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chem. Res. Toxicol. 18:516-527. [Download]
564. Jung, O., R.P. Brandes, I. Kim, F. Schweda, R. Schmidt, B.D. Hammock, R. Busse and I. Fleming. 2005. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension. 45:759-765. [Download]
565. Newman, J.W., J.E. Stok, J.D. Vidal, C.J. Corbin, Q. Huang, B.D. Hammock and A.J. Conley. 2004. Cytochrome P450-dependent lipid metabolism in preovulatory follicles. Endocrinology. 145:5097-5105. [Download]
571. Sellers, K.W., C. Sun, C. Diez-Freire, H. Waki, C. Morisseau, J.R. Falck, B.D. Hammock, J.F. Paton and M.K. Raizada. 2005. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. FASEB J. 19:626-628. [Download]
576. Kim, I.-H., F.R. Heirtzler, C. Morisseau, K. Nishi, H.-J. Tsai and B.D. Hammock. 2005. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J. Med. Chem. 48:3621-3629. [Download]
577. Aronov, P.A., K. Dettmer, J.A. Christiansen, A.J. Cornel and B.D. Hammock. 2005. Development of a HPLC/tandem-MS method for the analysis of the larvicides methoprene, hydroprene and kinoprene at trace levels using Diels-Alder derivatization. J. Agric. Food Chem. 53:3306-3312. [Download]
578 Nithipatikom, K., M.P. Endsley, M.A. Isbell, C.E. Wheelock, B.D. Hammock and W.B. Campbell. 2005. A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer. Biochem. Bioph. Res. Co. 332:1028-1033. [Download]
579. Jones, P.D., N.M. Wolf, C. Morisseau, P. Whetstone, B. Hock and B.D. Hammock. 2005. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal. Biochem. 343:66-75. [Download]
580. Fang, X., S. Hu, T. Watanabe, N.L. Weintraub, G.D. Snyder, J. Yao, Y. Liu, J. Y.-J. Shyy, B.D. Hammock and A.A. Spector. 2005. Activation of peroxisome proliferators-activated receptor a by substituted urea-derived soluble epoxide hydrolase inhibitors. J. Pharmacol. Exp. Ther. 314:260-270. [Download]
581. Schmelzer, K.R., L. Kubala, J.W. Newman, I.-H. Kim, J.P. Eiserich and B.D. Hammock. 2005. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc. Natl. Acad. Sci. USA. 102(28):9772-9777. PMCID:PMC 1168955. [Download]
583. Kang, K.-D., P.D. Jones, H. Huang, R. Zhang, L.A. Mostovich, C.E. Wheelock, T. Watanabe, L.F. Gulyaeva and B.D. Hammock. 2005. Evaluation of a-cyano ethers as fluorescent substrates for assay of cytochrome P450 enyzme activity. Anal. Biochem. 344:183-192. PMCID: PMC1450254. [Download]
584. Wheelock, C.E., K. J. Eder, I. Werner, H. Huang, P.D. Jones, B.F. Brammell, A.A. Elskus and B.D. Hammock. 2005. Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquat. Toxicol. 74:172-192. PMCID: PMC1444896. [Download]
585. German, J.B., B.D. Hammock and S.M. Watkins. 2005. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 1:3-9. PMCID:PMC1457093. [Download]
587. Tran, K.L., P.A. Aronov, H. Tanaka, J.W. Newman, B.D. Hammock and C. Morisseau. 2005. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Biochemistry-US. 44:12179-12187. PMCID: PMC1473036. [Download]
589. Liu, Y., Y. Zhang, K. Schmelzer, T.-S. Lee, X. Fang, Y. Zhu, A.A. Spector, S. Gill, C. Morisseau, B.D. Hammock and J.Y-J. Shyy. 2005. The anti-inflammatory effect of laminar flow: The role of PPAR?, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci. 102:16747-16752. PMCID:PMC 1276614. [Download]
590. Vriens, J., G. Owsianik, B. Fisslthaler, M. Suzuki, A. Janssens, T. Voets, C. Morisseau, B.D. Hammock, I. Fleming, R. Busse and B. Nilius. 2005. Modulation of the Ca2+ permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res. 97:908-915. PMCID: PMC1276614. [Download]
594. Dorrance, A.M., N. Rupp, D.M. Pollock,J.W. Newman, B.D. Hammock and J.D. Imig. 2005. An epoxide hydrolase inhibitor, 12-(3-Adamantan-1-yl-ureido) dodecanoic acid (AUDA) reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. J. Cardiovasc. Pharm. 46:842-848.PMCID: PMC1444897. [Download]