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Publications pertaining to liver diseases

024.  Mumby, S.M. and B.D. Hammock. 1979. Substrate selectivity and stereochemistry of enzymatic epoxide hydration in the soluble fraction of mouse liver. Pestic. Biochem. Physiol. 11:275-284. 


026.  Gill, S.S. and B.D. Hammock. 1979. Hydration of cis- and trans-epoxymethyl stearates by the cytosolic epoxide hydrase of mouse liver. Biochem. Biophys. Res. Commun. 89(3):965-971.  


031.  Hammock, B.D., S.S. Gill, S.M. Mumby and K. Ota. 1980. Comparison of epoxide hydrases in the soluble and microsomal fractions of mammalian liver. In: Molecular Basis of Environmental Toxicity, (Bhatnagar, R.S., ed.), pp. 229-272, Ann Arbor Science Publishers, Ann Arbor, Michigan.  


033.  Ota, K. and B.D. Hammock. 1980. Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver. Science. 207:1479-1481.  


035.  El-Tantawy, M.A. and B.D. Hammock. 1980. The effect of hepatic microsomal and cytosolic subcellular fractions on the mutagenic activity of epoxide-containing compounds in the Salmonella assay. Mutat. Res. 79:59-71.  


039.  Hammock, B.D., M. Ratcliff and D.A. Schooley. 1980. Hydration of an 180 epoxide by a cytosolic epoxide hydrolase from mouse liver. Life Sci. 27:1635-1641.  


043.  Gill, S.S. and B.D. Hammock. 1981. Epoxide hydrolase activity in the mitochondrial fraction of mouse liver. Nature. 291(5811):167-168.  


048.  Gill, S.S. and B.D. Hammock. 1981. Epoxide hydrolase activity in the mitochondrial and submitochondrial fractions of mouse liver. Biochem. Pharmacol. 30(15):2111-2120.  


063.  Hammock, B.D. and L.S. Hasagawa.  1983.  Differential substrate selectivity of murine hepatic cytosolic and microsomal epoxide hydrolases.  Biochem. Pharmacol.  32(7):1155-1164.  


068.  Gill, S.S., K. Ota, B. Ruebner and B.D. Hammock.  1983.  Microsomal and cytosolic epoxide hydrolases in rhesus monkey liver, and in normal and neoplastic human liver.  Life Sci.  32:2693-2700.  


090.  Moody, D.E., D.N. Loury and B.D. Hammock.  1985.  Epoxide metabolism in the liver of mice treated with clofibrate (ethyl-- (p-chlorophenoxyisobutyrate), a peroxisome proliferator.  Toxicol. Appl. Pharmacol.  78:351-362.  


098.  Hammock, B.D., G.D. Prestwich, D.N. Loury, P.Y.K. Cheung, W.S. Eng, S.K. Park, D.E. Moody, M.H. Silva and R.N. Wixtrom.  1986.  Comparison of crude and affinity purified cytosolic epoxide hydrolases from hepatic tissue of control and clofibrate-fed mice.  Arch. Biochem. Biophys.  244(1):292-309.  


102.  Moody, D.E., M.H. Silva and B.D. Hammock. 1986. Epoxide hydrolysis in the cytosol of rat liver, kidney, and testis. Measurement in the presence of glutathione and the effect of dietary clofibrate. Biochem Pharmacol. 35(13):2073-2080. PMID: 3015145.  


107.  Helferich, W.G., E.G. Carroad, M.D. Easter, D.E. Moody, B.D. Hammock and L.R. Shull.  1986.  Effect of medroxyprogesterone acetate on hepatic and placental drug metabolism in rats.  Biochem. Pharmacol.  35(20):3655-3658.  


109.  Wisniewski, J.A., D.E. Moody, B.D. Hammock and L.R. Shull.  1987.  Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep.  J. Anim. Sci.  64:210-215.  


110.  Gillette, D.M., R.D. Corey, W.G. Helferich, J.M. McFarland, L.J. Lowenstine, D.E. Moody, B.D. Hammock and L.R. Shull.  1987.  Comparative toxicology of tetrachlorobiphenyls in mink and rat.  I.  Changes in hepatic enzyme activity and smooth endoplasmic reticulum volume.  Fundam. Appl. Toxicol.  8:5-14.  


111.  Moody, D.E., D.N. Loury and B.D. Hammock.  1987.  Immunochemical determination of microsomal epoxide hydrolase (preneoplastic antigen) in extrahepatic tissue.  Biochem. Pharmacol.  36(4):570-572.  


115.  Silva, M.H. and B.D. Hammock.  1987.  Affinity purification of cytosolic epoxide hydrolase from human, rhesus monkey, baboon, rabbit, rat and mouse liver.  Comp. Biochem. Physiol.  87B(1):95-102.  


119.  Moody, D.E. and B.D. Hammock.  1987.  The effect of tridiphane (2-(3,5-dichloropohenyl)-2-(2,2,2-trichloroethyl) oxirane) on hepatic epoxide-metabolizing enzymes: Indications of peroxisome proliferation.  Toxicol. Appl. Pharmacol.  89:37-48.  


122.  Narloch, B.A., M.P. Lawton, D.E. Moody, B.D. Hammock and L.R. Shull.  1987.  The effects of dicofol on induction of hepatic microsomal metabolism in rats.  Pestic. Biochem. Physiol.  28:362-370.   


125.  Moody, D.E. and B.D. Hammock.  1987.  Purification of microsomal hydrolase from liver of rhesus monkey: Partial separation of cis- and trans-stilbene oxide hydrolase.  Arch. Biochem. Biophys.  258(1):156-166.  


134.  Magdalou, J. and B.D. Hammock.  1987.  Metabolism of tridiphane (2-(3,5-dichlorophenyl)-2(2,2,2-trichloroethyl) oxirane) by hepatic epoxide hydrolases and glutathione S-transferases in mouse.  Toxicol. Appl. Pharmacol.  91:439-449.  


137.  Moody, D.E., G.A. Clawson, D.A. Geller, L.A. Taylor, J. Button, D.N. Loury, B.D. Hammock and E.A. Smuckler.  1988.  Sodium cholate extraction of rat liver nuclear xenobiotic-metabolizing enzymes.  Biochem. Pharmacol.  37(7):1331-1341.  


138.  Silva, M.H., R.N. Wixtrom and B.D. Hammock.  1988.  Epoxide-metabolizing enzymes in mammary gland and liver from BALB/c mice and effects of inducers on enzyme activity.  Cancer Res.  48:1390-1397.  


143.  Magdalou, J. and B.D. Hammock.  1988.  1,2-Epoxycycloalkanes: Substrates and inhibitors of microsomal and cytosolic epoxide hydrolases in mouse liver.  Biochem. Pharmacol.  37(14):2717-2722.  


154.  Moody, D.E., B.D. Hammock, B.H. Ruebner, D.W. Hillman and J.H. Hillman.  1989.  Immunochemical comparison of human and rhesus monkey liver microsomal and the hepatocellular carcinoma-induced human serum epoxide hydrolases (preneoplastic antigens): Basis for an enzyme-linked immunoabsorbent assay.  Carcinogenesis.  10(2):343-349.  


155.  Lauren, D.J., P.P. Halarnkar, B.D. Hammock and D.E. Hinton. 1989. Microsomal and cytosolic epoxide hydrolase, and glutathione S-transferase activities in the gill, liver, and kidney of the rainbow trout, Salmo gairdneri: Baseline levels and optimization of assay conditions. Biochem Pharmacol. 38(6):881-887.  PMID: 2930590.  


156.  DiBiasio, K.W., M.H. Silva, B.D. Hammock and L.R. Shull.  1989.  Effects of hepatic inducers on testicular epoxide-metabolizing enzymes in the rat and mouse.  Fundam. Appl. Toxicol.  12:449-459.  


162.  Halarnkar, P.P., R.N. Wixtrom, M.H. Silva and B.D. Hammock.  1989.  Catabolism of epoxy fatty esters by the purified epoxide hydrolase from mouse and human liver.  Arch. Biochem. Biophys.  272(1):226-236.  


192.  Moody, D.E., K.A. Montgomery, M.B.A. Ashour and B.D. Hammock.  1991.  Effects of environmentally encountered epoxides on mouse liver epoxide-metabolizing enzymes.  Biochem. Pharmacol.  41(11):1625-1637.  


205.  Moody, D.E., B.A. Narloch, L.R. Shull and B.D. Hammock.  1991.  The effect of structurally divergent herbicides on mouse liver xenobiotic-metabolizing enzymes (P-450-dependent mono-oxygenases, epoxide hydrolases and glutathione S-transferases) and carnitine acetyltransferase.  Toxicology Letters.  59:175-185.  


219.  Moody, D.E., D.N. Loury, B.D. Hammock, B.H. Ruebner, J.M. Cullen, J.H. Hillman, D.W. Hillman, M.S. Rao, W.T. London, H.-W.L. Hann, I. Millman and M.J. Griffin.  1992.  Serum epoxide hydrolase (preneoplastic antigen) in human and experimental liver injury.  Cancer Epidemiol. Biomarkers & Prevention.  1:395-403.    


228.  Dietze, E.C., J. Casas, E. Kuwano and B.D. Hammock.  1993.  Inhibition of epoxide hydrolase from human, monkey, bovine, rabbit, and murine liver by trans-3-phenylglycidols.  Comp. Biochem. Physiol.  104B(2):309-314.  


231.  Parker, L.M., D.J. Lauren, B.D. Hammock, B. Winder and D.E. Hinton.  1993.  Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.  Carcinogenesis.  14(2):211-217.  


236.  Huang, T.L., S.A. Villalobos and B.D. Hammock.  1993.  Effect of hepatotoxic doses of paracetamol and carbon tetrachloride on the serum and hepatic carboxylesterase activity in mice.  J. Pharm. Pharmacol.  45:458-465.   


238.  Huang, T.L., A. Székács, T. Uematsu, E. Kuwano, A. Parkinson and B.D. Hammock.  1993.  Hydrolysis of carbonates, thiocarbonates, carbamates, and carboxylic esters of -naphthol, -naphthol, and p-nitrophenol by human, rat, and mouse liver carboxylesterases.  Pharm. Res.  10(5):639-648.   


240.  Beetham, J.K., T. Tian and B.D. Hammock.  1993.  cDNA cloning and expression of a soluble epoxide hydrolase from human liver  Arch. Biochem. Biophys.  305(1):197-201.  


241.  Grant, D.F., D.H. Storms and B.D. Hammock.  1993.  Molecular cloning and expression of murine liver soluble epoxide hydrolase.  J. Biol. Chem.  268(23):17628-17633.  


242.  Winder, B.S., J. Nourooz-Zadeh, R.R. Isseroff, M.F. Moghaddam and B.D. Hammock.  1993.  Properties of enzymes hydrating epoxides in human epidermis and liver.  Int. J. Biochem.  25(9):1291-1301.    


278.  Shiotsuki, T., T.L. Huang and B.D. Hammock.  1994.  Affinity purification of mouse liver carboxylesterase with trifluoromethyl ketones as ligands.  J. Pestic. Sci.  19(4):321-324.      


298.  Pinot, F., D.F. Grant, J.L. Spearow, A.G. Parker and B.D. Hammock. 1995. Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in liver and kidneys of mice. Biochem Pharmacol. 50(4):501-508. PMID: 7646556.  


328.  Parker, A.G., F. Pinot, D.F. Grant, J. Spearow and B.D. Hammock.  1996.  Regulation of mouse liver microsomal esterases by clofibrate and sexual hormones.  Biochem. Pharmacol.  51(5):677-685.  


338.  Zeldin, D.C., C.R. Moomaw, N. Jesse, K.B. Tomer, J. Beetham, B.D. Hammock and S. Wu.  1996.  Biochemical characterization of the human liver cytochrome P450 Arachidonic acid epoxygenase pathway.  Arch. Biochem. Biophys.  330(1):87-96.   


347.  Huang, T., T. Shiotsuki, T. Uematsu, B. Borhan, Q. Li and B. Hammock.  1996.  Structure-activity relationships for substrates and inhibitors of mammalian liver microsomal carboxylesterases.  Pharm. Res.  13(10):1495-1500.  


376.  Huang, T.L. and B. D. Hammock. 1997.  Solubilization of mouse liver microsomal carboxylesterases. Pharmaceutical Sciences.  3:605-608.  


411.  Draper, A.J. and B.D. Hammock.  1999.  Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver.  Toxicol. Sci.  50(1):30-35.  


415.  Argiriadi, M.A., C. Morisseau, B.D. Hammock and D.W. Christianson.  1999.  Detoxification of environmental mutagens and carcinogens: Structure, mechanism, and evolution of liver epoxide hydrolase.  Proc. Natl. Acad. Sci. USA  96(19):10637-10642.  


418.  Morisseau, C., M. Derbel, T.R. Lane, D. Stoutamire and B.D. Hammock.  1999.  Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats.  Toxicol. Sci. 52(2):148-153.   


419. Lakritz J, Winder BS, Noorouz-Zadeh J, Huang TL, Buckpitt AR, Hammock BD, Plopper CG (2000) Hepatic and pulmonary enzyme activities in horses. Am. J. Vet. Res. 61(2):152–157 


426.  Draper, A.J. and B.D. Hammock.  2000.  Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase.  Arch. Biochem. Biophys.  376(1):199-205.   


472.  Watanabe, T. and B.D. Hammock. 2001 Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high performance liquid chromatography with electrospray tandem mass spectrometry. Anal Biochem. 299:227-234.  


518.  Wheelock, C.E., Å.M. Karlsson, R. Zhang, J.E. Stok, C. Morisseau, S.E. Le Valley, C.E. Green and B.D. Hammock.  2003.  Evaluation of -cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes.  Anal. Biochem. 315(2):208-222. PMID: 12689831.  


545.  Stok, J.E., H. Huang, P.D. Jones, C.E. Wheelock, C. Morisseau and B.D. Hammock.  2004.  Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes.  J. Biol. Chem.  279:29863-29869.  PMID: 15123619  


588.  Huang, H., C.D. Fleming, K. Nishi, M.R. Redinbo and B.D. Hammock.  2005.  Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases.  Chem. Res. Toxicol.  18(9):1371-1377.  PMID: 16167828. PMCID:PMC 1444893.  


596.  Nishi, K., H. Huang, S.G. Kamita, I.-H. Kim, C. Morisseau and B.D. Hammock.  2006.  Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2.  Arch. Biochem. Biophys.  445:115-123.  PMID: 16359636. PMCID: PMC1444892.  


647.  Wheelock, C.E., S. Goto, B.D. Hammock and J.W. Newman. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics.  3(2):137-145. PMID: 19079556. PMCID: PMC2597807.  


703.  Fife, K.L., YM. Liu, K.R. Schmelzer, H-J. Tsai, I-H. Kim, C. Morisseau, B.D. Hammock and D.L. Kroetz. 2008. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J. Pharmacol. Exper. Therap. 327(3):707-715. PMCID: PMC2761654.  

796. Barhoumi, R., Y. Mouneimne, E. Ramos, C. Morisseau, B.D. Hammock, S. Safe, A.R. Parrish and R.C. Burghardt. 2011.  Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. Toxicol. Appl. Pharmacol. 253(1):45-56. PMCID: PMC3081912.  


834. Helferich, W.G., M.H. Silva, W.T. Flueck, B.D. Hammock and L.R. Shull. 1987. Xenobiotic biotransformation in livers and lungs of adult black-tailed deer: comparison with domestic goat and sheep. Comp Biochem Physiol C. 88(1):145-49. PMID: 2890476. 


850. Liu, Y., H.X. Dang, D. Li, W. Pang, B.D. Hammock and Y. Zhu. 2012. Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice. PLoS One. 7(6):e39165. PMID: 22720061. PMCID: PMC3375303. 

897. Bettaieb, A., N. Nagata, D. AbouBechara, S. Chahed, C. Morisseau, B.D. Hammock and F.G. Haj. 2013. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem. 288(20): 14189-99. PMID: 23576437. PMCID: PMC3656275.  


924. Yang, J., P. Solaimani, H. Dong, B.D. Hammock, O. Hankinson. 2013. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. J Toxicol Sci. 38(6):833-36. PMID: 24213002. PMCID: PMC4068614.  


974. Yueh, M.F., K. Taniguchi, S. Chen, R.M. Evans, B.D. Hammock, M. Karin and R.H. Tukey. 2014 Dec. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci USA. 111(48):17200-05. PMID: 25404284. PMCID: PMC4260592.  


981. Lopez-Vicario, C., V. Garcia-Alonso, J. Alcaraz-Quiles, B. Rius, E. Titos, A. Lopategi, B.D. Hammock, V. Arroyo and J. Claria. 2015 Jan. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver. Role for omega-3 epoxides. Proc Natl Acad Sci USA. 112(2):536-41. PMID: 25550510. PMCID: PMC4299190.  


991. Harris, T.R., A. Bettaieb, S. Kodani, H. Dong, R. Myers, N. Chiamvimonvat, F.G. Haj and B.D. Hammock. 2015 July. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 286(2):102-111. PMID: 25827057. PMCID: PMC4458210.  


1041. Wu, X., J. Yang, C. Morisseau, B.D. Hammock, H.J. Lehmler. 2016 Aug. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci. 152(2):309-22. PMID: 27208083. PMCID: PMC4960907.  


1051. Harris, T.R., S. Kodani, J. Yang, D.M. Imai and B.D. Hammock. 2016 Dec. An ω-3 enriched diet does not attenuate CCl4-induced hepatic fibrosis. J Nutr Biochem. 38:93-101. PMID: 27732914. PMCID: PMC5102762.  


1126. Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury. Mol Pharmacol. 2018. Epub 2018/05/31. 94(2):834-841. doi: 10.1124/mol.118.111831. PubMed PMID: 29844231. PMCID: PMC6022802. 


1150. Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM. 2019. Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver. Frontiers in Pharmacology. 10(580). doi: 10.3389/fphar.2019.00580. PMID: 31191316. PMCID: PMC6548860.  


1218. Zhang J, Tan Y, Chang L, Hammock BD, Hashimoto K. 2020. Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain - liver axis. J Affect Disord. 270:131-134. 10.1016/j.jad.2020.03.070.  PMCID: PMC7243919.  


1270. Sun C-C, Zhang C-Y, Duan J-X, Guan X-X, Yang H-H, Jiang H-L, Hammock BD, Hwang SH, Zhou Y, Guan C-X, Liu S-K, Zhang J. 2020. PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice. Biochemical and Biophysical Research Communications. 523(4):1020-1026. PMID: 31973813. PMCID: PMC7990110.  


1272. Mello A, Hsu MF, Koike S, Chu B, Cheng J, Yang J, Morisseau C, Torok NJ, Hammock BD, Haj FG. 2021. Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease. Cell Mol Gastroenterol Hepatol. 11(3):815-830. 10.1016/j.jcmgh.2020.10.002. PMID: 33068774. PMCID: PMC7851189.  


1289. Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, Hammock BD, Zhu Y. 2019. Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice. Am J Physiol Gastrointest Liver Physiol. 316(4):G527-g538. 10.1152/ajpgi.00148.2018. PMID: 30789748; PMCID: PMC6483021.  


1305. Tiwari S, Yang J, Morisseau C, Durbin-Johnson B, Hammock BD, Gomes AV. 2021. Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Scientific reports. 11(1):7042. 10.1038/s41598-021-86284-1. PMID: 33782432. PMCID: PMC8007717.  

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