Name |
Research Project |
|
Katrin Georgi |
Metabolomics (i.e. Metabolomic study of ozone and 1-nitronaphthalene toxicity); Oxylipin analysis; Development of analytical methods for LC-MS/MS and GC (i.e. endocannabinoids; lipid amides). |
|
Todd Harris |
Characterization of soluble epoxide hydrolases from non-mammalian species. Isolation, purification and enzyme inhibition. |
|
Christine Hegedus |
Ozone exposure, in silico model validation of in vitro data, sEH interaction with NFkB, sEHI in pain and inflammation. |
|
Sung Hee Hwang |
Development of COX-2/sEH dual inhibitors as safe anti-inflammatiory drugs. Discovery of compounds that can inhibit both COX-2 and sEH enzymes using modern medicinal approach. |
|
Ahmet 'Bora' Inceoglu |
Assessment of the role of sEH in nervous system. Investigate the effects of inhibiting sEH in animal models of pain. |
|
Hee Joo Kim |
Development of immunoassays for pyrethroid metabolites. Development of novel immunoassay formats using phage peptide display. |
|
Junyan Liu |
Evaluation of sEH inhibitors’ efficacy in animal models. Exploration of the crosstalk between P450 (sEH) and other pathways (COX & LOX). Investigation of the role of sEH in the development, prevention, and treatment of COPD using metabolomics methods. |
|
Mikaela Nichkova |
Application of immunoassays for contaminants and their metabolites to environmental and biological samples. Development of new detection formats (biosensors, arrays, cell labeling) based on fluorescent and/or magnetic immunoassays using nanoparticles (QDots, europium oxide, etc.) as labels. Detection of food-borne toxins (e.g. BoTox) and plant toxins (e.g. ricin) in food samples with multifunctional nanoparticles. |
|
Jun Yang |
Metabolomics, LC/MS and GC/MS methods development, chemometrics. |
|
Angela Zivkovic |
Eicosanoid biology and nutritional modulation of inflammation, with a focus on omega-3 fatty acids. How omega-3 fatty acids modulate lipid signaling in various inflammatory disease states, including metabolic disease and kidney disease. |