Todd Harris (752-6571)
Ph.D.: Biochemistry and Molecular Biology, University of California-Davis, USA
Sung Hee Hwang (754-8884)
1) Synthesis and biological evaluation of dual inhibitors for cyclooxygenase-2 and soluble epoxide hydrolase using structure-based design and modern medicinal chemistry tools.
2) Design and synthesis of inhibitors for human soluble epoxide hydrolase by parallel and combinatorial synthesis for the lead optimization based on SAR study, physical property determination and PK analysis.
3) Development of novel fluorescent assay reagents for rapid and precise measurement of environmental contaminants by labeling them with two fluorophores called “molecular tripod”.
Ahmet 'Bora' Inceoglu (752-6571)
Assessment of the role of sEH in nervous system. Investigate the effects of inhibiting sEH in animal models of pain.
Christophe Morisseau (752-6571)
Study the role of esterases and epoxide hydrolases in biology and xenobiotics metabolism. Toward this purpose, study their mechanism of action, develop specific inhibitors and design fluorescent reporter assay; as well as studying the kinetic of hydrolysis of natural substrates. All of these mainly in mammals; but also in other organism such as chicken or bacteria. Study also the role of the phosphatase activity of sEH.
Jun Yang (752-5109)
1) Role of soluble epoxide hydrolase in lung diseases including asthma and Chronic Obstructive Pulmonary Disease.
2) Metabolomics method development and applications including the profiling of the oxylipins such as eicosanoids.
3) Qualification and Quantification of small molecules using chromatography and mass spectrometry.
4) Identification of proteins by chromatography and mass spectrometry.